Results 31 to 40 of about 172,602 (315)

Applying an Improving Strategy that embeds Functional and Non-Functional Requirements Concepts

Journal of Computer Science and Technology, 2019
Organizations should set and reach business goals for varied purposes using the suitable strategies. Basically, a strategy specifies the activities, methods and another related resources that should be considered in order to achieve a given goal purpose.
Pablo Becker, Guido Tebes, Denis Peppino, Luis Olsina   +3 more
doaj   +1 more source

Wearable multimode sensor with a seamless integrated structure for recognition of different joint motion states with the assistance of a deep learning algorithm

Microsystems & Nanoengineering, 2022
Accurate motion feature extraction and recognition provide critical information for many scientific problems. Herein, a new paradigm for a wearable seamless multimode sensor with the ability to decouple pressure and strain stimuli and recognize the ...
Lei Wen, Meng Nie, Pengfan Chen, Yu-na Zhao, Jingcheng Shen, Chongqing Wang, Yuwei Xiong, Kuibo Yin, Litao Sun   +8 more
doaj   +1 more source

PICO-60 Results and PICO-40L Status

Journal of Physics: Conference Series, 2020
Abstract PICO-60 and PICO-40L are bubble chambers for dark matter searches that are using C3F8 as active liquid. PICO-60 was operated successfully at SNOLAB until 2017 and PICO-40L is now operating in the same location. PICO-40L follows a new detector concept that holds promise for future increases of sensitivity.
openaire   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

REHABILITACION DE SUELOS HORTÍCOLAS: IMPACTO DE PRÁCTICAS AGRÍCOLAS CON USO DE YESO Y DRENAJE

Fave: Sección Ciencias Agrarias, 2017
El exceso de Na + , carbonatos y bicarbonatos presentes en el agua de riego incrementan el pH, la conductividad eléctrica (CE) y el porcentaje de sodio intercambiable (PSI), afectando el crecimiento de los cultivos.
A. MUGUIRO, C. ÁLVAREZ, F. BABINEC, R. MARANO   +3 more
doaj   +1 more source

Interaction of HS1BP3 with cortactin modulates TKS5 localisation, cell secretion and cancer malignancy

Molecular Oncology, EarlyView.
Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen, Kristiane Søreng, Chiara Veroni, Laura Trachsel‐Moncho, Nagham Asp, Robin Gaupset, Lars Gustav Lyckander, Helene Knævelsrud, Lars Eftang, Anne Simonsen   +9 more
wiley   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Diagnostic and Prognostic Value of Hyperammonemia in Patients with Liver Cirrhosis, Hepatic Encephalopathy, and Sarcopenia (Experts’ Agreement)

Российский журнал гастроэнтерологии, гепатологии, колопроктологии
Introduction. In cirrhotic patients, hyperammonemia develops due to impaired ammonia detoxification and portosystemic blood shunting and is most commonly associated with hepatic encephalopathy and sarcopenia.
M. Yu. Nadinskaia, M. V. Maevskaya, I. G. Bakulin, E. N. Bessonova, A. O. Bueverov, M. S. Zharkova, S. V. Okovityi, A. S. Ostrovskaya, K. A. Gulyaeva, V. T. Ivashkin   +9 more
doaj   +1 more source

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source

Correction of Thrombocytopenia before Elective Surgery / Invasive Procedures in Patients with Liver Cirrhosis (Experts’ Agreement)

Российский журнал гастроэнтерологии, гепатологии, колопроктологии
Introduction. As a result of portal hypertension (sequestration of platelets in an enlarged spleen) and liver failure (decreased production of thrombopoietin in the liver) in liver cirrhosis, thrombocytopenia develops, which is associated with the risk ...
M. V. Maevskaya, M. Yu. Nadinskaia, E. N. Bessonova, N. I. Geyvandova, M. S. Zharkova, E. A. Kitsenko, N. V. Korochanskaya, I. A. Kurkina, A. L. Melikyan, V. G. Morozov, Yu. V. Khoronko, T. A. Deeva, K. A. Gulyaeva, V. T. Ivashkin   +13 more
doaj   +1 more source