Results 31 to 40 of about 707,531 (297)

PICO-60 Results and PICO-40L Status

Journal of Physics: Conference Series, 2020
Abstract PICO-60 and PICO-40L are bubble chambers for dark matter searches that are using C3F8 as active liquid. PICO-60 was operated successfully at SNOLAB until 2017 and PICO-40L is now operating in the same location. PICO-40L follows a new detector concept that holds promise for future increases of sensitivity.
openaire   +1 more source

The planar cell polarity protein Vangl2 interacts with the PDZ‐domains of Scribble but not with a unique PDZ‐like domain in Inturned

FEBS Letters, EarlyView.
Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes, Jan Brysch, Carmen Gelze, Lilli Meier, Daniel Kümmel   +4 more
wiley   +1 more source

Applying an Improving Strategy that embeds Functional and Non-Functional Requirements Concepts

Journal of Computer Science and Technology, 2019
Organizations should set and reach business goals for varied purposes using the suitable strategies. Basically, a strategy specifies the activities, methods and another related resources that should be considered in order to achieve a given goal purpose.
Pablo Becker, Guido Tebes, Denis Peppino, Luis Olsina   +3 more
doaj   +1 more source

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

REHABILITACION DE SUELOS HORTÍCOLAS: IMPACTO DE PRÁCTICAS AGRÍCOLAS CON USO DE YESO Y DRENAJE

Fave: Sección Ciencias Agrarias, 2017
El exceso de Na + , carbonatos y bicarbonatos presentes en el agua de riego incrementan el pH, la conductividad eléctrica (CE) y el porcentaje de sodio intercambiable (PSI), afectando el crecimiento de los cultivos.
A. MUGUIRO, C. ÁLVAREZ, F. BABINEC, R. MARANO   +3 more
doaj   +1 more source

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

Molecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge, Morten Tulstrup, Gabriele Todisco, Pedro Moura, Christophe Côme, Jakob Werner Hansen, Jakob Schmidt Jespersen, Balthasar Schlotmann, Maria Creignou, Mette Dahl, Claudia Schöllkopf, Klas Raaschou‐Jensen, Krister Wennerberg, Bo Porse, Joachim Weischenfeldt, Eva Hellström‐Lindberg, Lasse Sommer Kristensen, Kirsten Grønbæk   +17 more
wiley   +1 more source

Restricciones y prejuicios en torno a las relaciones sentimentales y familiares de la comunidad esclava en tiempos de la independencia de Colombia [PDF]

, 2014
e ste artículo aborda la complejidad de la vida afectiva de la población esclava durante el proceso de i ndependencia de c olombia. e n términos generales, muchas de las limitaciones establecidas durante el periodo colonial siguieron vigentes, tanto en ...
Roger Pita Pico
core   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Diagnostic and Prognostic Value of Hyperammonemia in Patients with Liver Cirrhosis, Hepatic Encephalopathy, and Sarcopenia (Experts’ Agreement)

Российский журнал гастроэнтерологии, гепатологии, колопроктологии
Introduction. In cirrhotic patients, hyperammonemia develops due to impaired ammonia detoxification and portosystemic blood shunting and is most commonly associated with hepatic encephalopathy and sarcopenia.
M. Yu. Nadinskaia, M. V. Maevskaya, I. G. Bakulin, E. N. Bessonova, A. O. Bueverov, M. S. Zharkova, S. V. Okovityi, A. S. Ostrovskaya, K. A. Gulyaeva, V. T. Ivashkin   +9 more
doaj   +1 more source

Interaction of HS1BP3 with cortactin modulates TKS5 localisation, cell secretion and cancer malignancy

Molecular Oncology, EarlyView.
Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen, Kristiane Søreng, Chiara Veroni, Laura Trachsel‐Moncho, Nagham Asp, Robin Gaupset, Lars Gustav Lyckander, Helene Knævelsrud, Lars Eftang, Anne Simonsen   +9 more
wiley   +1 more source