Asian Pacific Journal of Tropical Medicine, 2014 Picralima nitida Durand and Hook, (fam. Apocynaceae) is a West African plant with varied applications in African folk medicine. Various parts of the plant have been employed ethnomedicinally as remedy for fever, hypertension, jaundice, dysmenorrheal, gastrointestinal disorders and malaria.
Erharuyi, Osayemwenre +2 more
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Journal of Nature and Science of MedicineBackground: Caspase-1 and CYP11A1 genes play crucial roles in inflammation and steroid hormone biosynthesis, both of which might be implicated in the toxic effects of benzene on the blood.
Progress Arhenrhen Obazelu +1 more
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Journal of Applied Sciences and Environmental ManagementPicralima nitida and Cymbopogon citratus has been associated with anti-inflammatory and hematopoietic properties, hinting at their potential effectiveness in addressing the complications of anaemia.
P. A. Obazelu, F. O. Ogiza
doaj
Toxicopathological evaluation of Picralima nitida seed aqueous extract in Wistar rats
Turkish Journal of Biochemistry, 2014 Objective: Picralima nitida is a widely used medicinal plant in West Africa for treating malaria, diarrhea and inflammation. The objective of this study is to evaluate the toxicological effect of aqueous seed extract of the plant in Wistar rats. Methods: Twenty-four apparently healthy animals were randomized into 4 groups comprising 6 rats each and ...
Taofik Olatunde Sunmonu +4 more
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Selected Preclinical Studies on Picralima nitida Stem Bark Extract
Tropical Journal of Drug ResearchPurpose: Traditional medicine has utilized Picralima nitida (Apocynaceae) to treat a variety of illnesses, including microbial and pain-induced infections, diabetes, inflammation, and malaria. Methods: The phytochemical screening, haematological, and histological studies were carried out using already established methods.
Osahon K. Ogbeide +7 more
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Antiplasmodial and anti-trypanosomial monoterpene indole alkaloids from Picralima nitida
Natural Product ResearchEight monoterpene indole alkaloids (1–8), including one new picraline-type alkaloid, 2-hydroxyakuammiline (4) and seven known compounds: akuammigine (1), akuammine (2), akuammidine (3), akuammiline (5a), akuammiline N-oxide (5b), akuammiline (6), rhazimol (7), and alstonine (8) were isolated from the seeds of Picralima nitida. Structure elucidation was
Michael Konney Laryea +5 more
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Cytochrome P450 Enzyme Inhibition and Herb-Drug Interaction Potential of Medicinal Plant Extracts Used for Management of Diabetes in Nigeria. [PDF]
Eur J Drug Metab Pharmacokinet, 2021 Amaeze O +4 more
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Determination of Nitric Oxide In PICRALIMA NITIDA
In this study, the qualitative and quantitative phytochemical screening of Picrilima nitida revealed the presence of important bioactive agents such as alkaloids, tannins, saponins, phenols, glycosides, terpenoids, flavonoids, steroids, phytosterols, and proanthocyanidins In addition to these phytochemicals, P.
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Evaluation of Nigerian Medicinal Plants Extract on Human P-glycoprotein and Cytochrome P450 Enzyme Induction: Implications for Herb-drug Interaction. [PDF]
Curr Drug Metab, 2021 Amaeze O +6 more
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Assessment of an ethanolic seed extract of Picralima nitida ([Stapf] Th. and H. Durand) on reproductive hormones and its safety for use. [PDF]
J Intercult Ethnopharmacol, 2015 Otoo LF +5 more
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