Results 111 to 120 of about 190,321 (310)

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

open access: yesMolecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller   +10 more
wiley   +1 more source

Lexical organization in deaf children who use British Sign Language: Evidence from a semantic fluency task [PDF]

open access: yes, 2013
We adapted the semantic fluency task into British Sign Language (BSL). In Study 1, we present data from twenty-two deaf signers aged four to fifteen. We show that the same ‘cognitive signatures’ that characterize this task in spoken languages are also ...
Marshall, C. R.   +9 more
core   +1 more source

Epigenetic silencing of the liver‐specific lncRNA LUNAR promotes liver cancer progression via NOTCH activation

open access: yesMolecular Oncology, EarlyView.
LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang   +9 more
wiley   +1 more source

Language uncovers visuospatial dysfunction in posterior cortical atrophy: a natural language processing approach

open access: yesFrontiers in Neuroscience
IntroductionPosterior Cortical Atrophy (PCA) is a syndrome characterized by a progressive decline in higher-order visuospatial processing, leading to symptoms such as space perception deficit, simultanagnosia, and object perception impairment.
Neguine Rezaii   +8 more
doaj   +1 more source

Spatial biology in cancer epigenetics

open access: yesMolecular Oncology, EarlyView.
Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley   +1 more source

Fragmentação da imagem da representação

open access: yesPós: Revista do Programa de Pós-Graduação em Arquitetura e Urbanismo da FAUUSP, 1996
The language of painting and urban landscape. The city seen by a painter. The fragmentation of a painted picture. Plane picture: painting and collage. Three dimensional picture: relief. Painting with urban waste.
Mário Fiore Moreira Junior
doaj  

Dorsolateral Prefrontal Transcranial Direct Current Stimulation Modulates Language Processing but Does Not Facilitate Overt Second Language Word Production

open access: yesFrontiers in Neuroscience, 2018
Word retrieval in bilingual speakers partly depends on executive control systems in the left prefrontal cortex – including dorsolateral prefrontal cortex (DLPFC).
Narges Radman   +7 more
doaj   +1 more source

Retreat bounded picture languages

open access: yesTheoretical Computer Science, 1994
AbstractA well-known string-encoding of 2D pictures is to use the picture alphabet π = {u, d, r, l}, where u (d, r, and l) means “draw a unit-line by moving the pen up (down, right, and left) from the current point”. A word over π is k-retreat-bounded (k⩾0) if it describes a picture in such a manner that the maximum distance of left-moves, ignoring up-
openaire   +2 more sources

Polarization‐resolved femtosecond Vis/IR spectroscopy tailored for resolving weak signals in biological samples using minimal sample volume

open access: yesFEBS Open Bio, EarlyView.
Unique biological samples, such as site‐specific mutant proteins, are available only in limited quantities. Here, we present a polarization‐resolved transient infrared spectroscopy setup with referencing to improve signal‐to‐noise tailored towards tracing small signals. We provide an overview of characterizing the excitation conditions for polarization‐
Clark Zahn, Karsten Heyne
wiley   +1 more source

Stimulating language: insights from TMS [PDF]

open access: yes, 2006
Fifteen years ago, Pascual-Leone and colleagues used transcranial magnetic stimulation (TMS) to investigate speech production in pre-surgical epilepsy patients and in doing so, introduced a novel tool into language research.
Watkins, Kathryn   +4 more
core   +2 more sources

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