Results 121 to 130 of about 329,302 (315)
Interrogating the immune landscape of microsatellite stable RAS‐mutated colon cancer
Molecular Oncology, EarlyView.COLOSSUS project RAS‐mutated MSS colon cancer study explored transcriptomics and immune cell density by immunohistochemistry (IHC), Immunoscore (IS), ISIC/TuLIS scores, mutation counts, and detected different prevalences but similar microenvironment composition across immune markers with clinical relevance for future immunotherapy combination ...
Rodrigo Dienstmann +61 more
wiley +1 more source
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
The Hindi language film Swades: We, the People: A different kind of journey to the East.
, 2013 The analysis of motion picture depictions of leadership, as noted by numerous scholars of leadership education, lends itself well as a tool for conveying core values of leadership.
Reynolds, Kae
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Molecular Oncology, EarlyView.Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch +13 more
wiley +1 more source
Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma
Molecular Oncology, EarlyView.The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic +5 more
wiley +1 more source
Sphinx and the Pyramid of Cephren [picture] : [Egypt, World War II] /
, 1939 Part of the Hurley negative collection.; Condition: torn corner.; Caption from unknown source on NLA cover. The processional way leading from the Pyramid to the funerary temple, Chephren's valley Temple, left can be seen centre of picture.; Hurley series:
Hurley, Frank, 1885-1962.
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Molecular Oncology, EarlyView.Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute +4 more
wiley +1 more source
Вестник Кемеровского государственного университета, 2016 The paper is devoted to the study of the Russian and the Chinese phraseology, which includes lexical components with names of animals. The purpose of this paper is to reveal the peculiarities of perception and functioning of zoophraseologisms and ...
Olga A. Bulgakova, Olga A. Krasnoborova
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Portrait of John Jeanes, retired farmer, Drouin, Victoria [picture] /
, 1944 Title devised by cataloguer from caption on verso.; Condition: Good.; Part of the collection: Drouin town and rural life during World War II.; "U429/3. John F.S.Jeanes, 82, retired farmer, likes to sun himself on a bench in Main Street Drouin. He was one
Fitzpatrick, Jim, 1916-
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Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer
Molecular Oncology, EarlyView.Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni +11 more
wiley +1 more source