Results 141 to 150 of about 329,302 (315)
Molecular Oncology, EarlyView.EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain +10 more
wiley +1 more source
Aerial view of Drouin, Victoria, during World War II [5] [picture]
, 1944 Title devised by cataloguer from caption on verso.; Condition: Good.; Part of the collection: Drouin town and rural life during World War II.; Also available in an electronic version via the Internet at: http://nla.gov.au/nla.pic ...
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Molecular Oncology, EarlyView.We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu +10 more
wiley +1 more source
Around the World in 106 Days [Motion Picture Film]
, 1953 Around the World in 106 Days film begins in New York at the Cunard Line Caronia building for the start of a world cruise. There are views of the ship and a 'Neptune' theatrical play onboard ship.
Herzfeld, Richard Phillip (1898-1980)
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Molecular Oncology, EarlyView.Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen +9 more
wiley +1 more source
Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source
Damascus Beirut Rd near Ainsofar, Lebanons [picture] : [Syria, World War II] /
, 1910 Part of the Hurley negative collection.; Condition: silvering.; "Print one picture only bring up all detail possible." Caption on cover.; Hurley series: Syria, World War ...
Hurley, Frank, 1885-1962.
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Molecular Oncology, EarlyView.Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata +10 more
wiley +1 more source
Maternal belief in a just world and moral commentary during picture book reading in infancy. [PDF]
Front PsycholKishimoto T, Kurihara A.
europepmc +1 more source
Kelly in the bush 1945 [picture] /
, 1945 Title from accompanying information.; Part of the collection: The Nolan Gallery's foundation collection.; Digital copy made by the National Library of Australia from the original paintings now held by the Canberra Museum and Gallery.; Copy originally ...
Nolan, Sidney, Sir, 1917-1992
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