Effect of Dupilumab on Airway Inflammation in Patients With Persistent Asthma
Allergy, EarlyView.EXPEDITION (NCT02573233) assessed the effects of dupilumab on airway inflammation in patients with persistent asthma using bronchoscopy and gene expression analysis. Dupilumab showed no appreciable effect on inflammatory cell types in biopsies or BALF samples.
Michael E. Wechsler +22 more
wiley +1 more source
The Airway Transcriptome in Type 2 Cytokine Biomarker‐High and ‐Low Severe Asthma
Allergy, EarlyView.This study distinguishes severe asthma–related airway transcriptomic changes from the effects of high‐dose ICS. Most dysregulated genes in severe asthma show concordance with corticosteroid responses. Corticosteroid‐resistant T2‐high asthma featured T2‐high and epithelial barrier gene upregulation, while T2‐low asthma featured Th1/IL‐17 signatures. ASM,
Jiashu Shen +19 more
wiley +1 more source
A novel adaptive Gaussian FOPID controller design for automatic voltage regulator system. [PDF]
Sci RepBaslik S, Akyazi O.
europepmc +1 more source
Immune System Development—Pro Tips for Paediatricians
Acta Paediatrica, EarlyView.ABSTRACT There are many misconceptions about the immune system in children, its impact on infectious disease susceptibility and its role in the rapidly increasing rates of immune mediated diseases in industrialized societies. In this mini review, I will discuss common believes and the data supporting or countering such believes, with a focus on ...
Petter Brodin
wiley +1 more source
Particle swarm optimization tuned LQR controller design for enhanced active suspension performance in repurposed medium public buses under varied road conditions. [PDF]
Sci RepMelaku TB, Ali HA, Kebede MS.
europepmc +1 more source
Novel therapeutic targets for chronic visceral pain in gastrointestinal disorders
British Journal of Pharmacology, EarlyView.Chronic visceral pain imposes a major clinical challenge in gastroenterology and beyond, profoundly impacting patients' quality of life. However, limited understanding of its complex, multifaceted pathophysiology, encompassing both peripheral and central mechanisms, continues to impede the development of effective management strategies.
Fleur Veldman +3 more
wiley +1 more source
Cascaded adaptive model predictive and PID control for integrated LFC-AVR enhancement. [PDF]
Sci RepAyman M, Attia MA, Asim AM.
europepmc +1 more source
Digital Professional Practice, Digital Competences and Impact on Family Support Services
Child &Family Social Work, EarlyView.ABSTRACT Digital‐mediated practices in public social services require new strategies for administration, communication, assessment and intervention. Within this field, research framed under UNESCO's (2020) Media and Information Literacy model—examining digital media management and digital competence in information management, communication, digital ...
Guacimara Rodríguez +6 more
wiley +1 more source
Closed-Loop Optogenetic Control in a Microplate Reader. [PDF]
ACS Synth BiolNamboothiri HR +4 more
europepmc +1 more source
Child &Family Social Work, EarlyView.ABSTRACT This study examined the efficacy of a 5‐week combined psychoeducation and support programme aimed at enhancing emotional competencies and psychological well‐being among Spanish auxiliary grandparent caregivers. Two delivery formats (face‐to‐face and synchronous online) were compared with a control group receiving no intervention, and ...
Cristina Noriega +4 more
wiley +1 more source