Results 131 to 140 of about 2,645,992 (293)
A dose‐finding population pharmacokinetic/pharmacodynamic model of ginisortamab, an anti‐gremlin‐1 monoclonal antibody, in patients with solid tumours
British Journal of Clinical Pharmacology, EarlyView.Aims
Ginisortamab, a first‐in‐class human monoclonal antibody for the treatment of advanced solid tumours, binds to gremlin‐1 and restores bone morphogenetic protein signalling. We used pharmacokinetic/pharmacodynamic (PK/PD) modelling to characterize the relationship between ginisortamab dose and serum gremlin‐1 binding, using model‐based simulations ...Yin Cheong Wong, Luisa Rojas Chavarro, Paul Jones, David Egging, Wanchana Ungphakorn, Marta Valle, Ivan Matthews +6 morewiley +1 more sourceOperations of and Future Plans for the Pierre Auger Observatory
, 2009 Technical reports on operations and features of the Pierre Auger Observatory,
including ongoing and planned enhancements and the status of the future
northern hemisphere portion of the Observatory.Abraham, J., Abreu, P., Aglietta, M., agoret-Campagne, S., Aguirre, C., Agüera, A. Lopez, Ahn, E. J., Albarracin, F. Gomez, Allard, D., Allekotte, I., Allen, J., Alvarez-Muñiz, J., Amaral, M. Gonçalves do, Ambrosio, M., Anchordoqui, L., Andringa, S., Anjos, J. C. dos, Anzalone, A., Aramo, C., Arganda, E., Argirò, S., Arisaka, K., Arneodo, F., Arqueros, F., Asch, T., Asorey, H., Assis, P., Aublin, J., Ave, M., Avila, G., Badagnani, D., Bahilo, J. Lozano, Barber, K. B., Barbosa, A. F., Barroso, S. L. C., Baughman, B., Bauleo, P., Beatty, J. J., Beau, T., Becker, B. R., Becker, K. H., Bellido, J. A., Bellétoile, A., BenZvi, S., Berat, C., Berisso, M. Gómez, Bernardini, P., Bertou, X., Biermann, P. L., Billoir, P., Blanch-Bigas, O., Blanco, F., Bleve, C., Blümer, H., Boháčová, M., Boncioli, D., Bonifazi, C., Bonino, R., Borodai, N., Brack, J., Bravo, O. Martínez, Brogueira, P., Brown, W. C., Bruijn, R., Buchholz, P., Bueno, A., Burton, R. E., Busca, N. G., Bäcker, T., Caballero-Mora, K. S., Caramete, L., Caruso, R., Carvalho, W., Castellina, A., Catalano, O., Cazon, L., Cester, R., Chauvin, J., Chiavassa, A., Chinellato, J. A., Chou, A., Chudoba, J., Chye, J., Clay, R. W., Colombo, E., Conceição, R., Connolly, B., Contreras, F., Coppens, J., Cordier, A., Cotti, U., Coutu, S., Covault, C. E., Creusot, A., Criss, A., Cronin, J., Curutiu, A., D'Olivo, J. C., D'Urso, D., Dallier, R., Daumiller, K., Dawson, B. R., de Almeida, R. M., De Domenico, M., De Donato, C., de Jong, S. J., De La Vega, G., De Mitri, I., de Oliveira, M. A. Leigui, de Souza, V., de Vries, K. D., Decerprit, G., del Peral, L., Deligny, O., Della Selva, A., Dembinski, H., Diaz, J. C., Diep, P. N., DiGiulio, C., Dobrigkeit, C., Dong, P. N., Dorofeev, A., Dova, M. T., Dutan, I., DuVernois, M. A., Engel, R., Erdmann, M., Escobar, C. O., Etchegoyen, A., Falcke, H., Falcon, H. R. Marquez, Farrar, G., Fauth, A. C., Fazzini, N., Ferrer, F., Ferrero, A., Fick, B., Filevich, A., Filipčič, A., Fleck, I., Fliescher, S., Fracchiolla, C. E., Fraenkel, E. D., Fratte, C. Delle, Fulgione, W., Galicia, J. F. Valdés, Gamarra, R. F., Gambetta, S., Garcia-Pinto, D., García, B., GarcíaGámez, D., Garrido, X., Gelmini, G., Gemmeke, H., Ghia, P. L., Giaccari, U., Giller, M., Glass, H., Goggin, L. M., Gold, M. S., Golup, G., Gonzalez, D., Gonzalez, J. G., Gonçalves, P., Gorgi, A., Gouffon, P., Gozzini, S. R., Grashorn, E., Grebe, S., Grigat, M., Grillo, A. F., Guardincerri, Y., Guarino, F., Guedes, G. P., Gutiérrez, J., Góra, D., Hague, J. D., Halenka, V., Hansen, P., Harari, D., Harmsma, S., Harton, J. L., Haungs, A., Healy, M. D., Hebbeker, T., Hebrero, G., Heck, D., Holmes, V. C., Homola, P., Horneffer, A., Hrabovský, M., Huege, T., Hussain, M., Hörandel, J. R., Iarlori, M., Insolia, A., Ionita, F., Italiano, A., Jiraskova, S., Junior, W. J. M. de Mello, Kaducak, M., Kampert, K. H., Karova, T., Kasper, P., Keilhauer, B., Kemp, E., Kieckhafer, R. M., Klages, H. O., Kleifges, M., Kleinfeller, J., Knapik, R., Knapp, J., Koang, D. -H., Krieger, A., Kruppke-Hansen, D., Krömer, O., Kuehn, F., Kuempel, D., Kulbartz, K., Kunka, N., Kusenko, A., Kégl, B., Lachaud, C., Lago, B. L., LaRosa, G., Lautridou, P., Lebrun, D., Lebrun, P., Lee, J., Lemiere, A., Letessier-Selvon, A., Leuthold, M., Leão, M. S. A. B., Lhenry-Yvon, I., Louedec, K., Lucero, A., Luis, P. Facal San, Lyberis, H., López, R., Maccarone, M. C., Macolino, C., Maldera, S., Mandat, D., Mantsch, P., Mariazzi, A. G., Maris, I. C., Martello, D., Martino, J. Rodriguez, Mathes, H. J., Matthews, J., Matthews, J. A. J., Matthiae, G., Maurizio, D., Mazur, P. O., McEwen, M., McNeil, R. R., Medina-Tanco, G., Melissas, M., Melo, D., Menichetti, E., Menshikov, A., Meyhandan, R., Micheletti, M. I., Miele, G., Miller, W., Miramonti, L., Mollerach, S., Monasor, M., Montanet, F., Morales, B., Morello, C., Moreno, J. C., Morris, C., Mostafá, M., Moura, C. A., Mueller, S., Muller, M. A., Mussa, R., Navarra, G., Navarro, J. L., Navas, S., Necesal, P., Nellen, L., Neto, J. R. T. de Mello, Newman-Holmes, C., Newton, D., Nhung, P. T., Nierstenhoefer, N., Nitz, D., Nosek, D., Nožka, L., Nyklicek, M., Oehlschläger, J., Olinto, A., Oliva, P., Olmos-Gilbaja, V. M., Ortiz, M., Pacheco, N., Palatka, M., Pallotta, J., Parente, G., Parizot, E., Parlati, S., Pastor, S., Patel, M., Paul, T., Pavlidou, V., Payet, K., Pech, M., Peixoto, C. J. Todero, Pepe, I. M., Perrone, L., Pesce, R., Petermann, E., Petrera, S., Petrinca, P., Petrolini, A., Petrov, Y., Petrovic, J., Pfendner, C., Piegaia, R., Pierog, T., Pimenta, M., Pinto, T., Pirronello, V., Pisanti, O., Platino, M., Pochon, J., Ponce, V. H., Pontz, M., Privitera, P., Prouza, M., Pȩkala, J., Quel, E. J., Ragaigne, D. Monnier, Rautenberg, J., Ravel, O., Ravignani, D., Redondo, A., Revenu, B., Rezende, F. A. S., Ridky, J., Riggi, S., Risse, M., Rivière, C., Rizi, V., Robledo, C., Rodriguez, G., Rodriguez-Cabo, I., Rodríguez-Frías, M. D., Rojo, J. Rodriguez, Ros, G., Rosado, J., Rossler, T., Roth, M., Rouillé-d'Orfeuil, B., Roulet, E., Rovero, A. C., Salamida, F., Salazar, H., Salina, G., Santander, M., Santo, C. E., Santos, E. M., Sarazin, F., Sarkar, S., Sato, R., Scharf, N., Scherini, V., Schieler, H., Schiffer, P., Schmidt, A., Schmidt, F., Schmidt, T., Scholten, O., Schoorlemmer, H., Schovancova, J., Schovánek, P., Schroeder, F., Schulte, S., Schuster, D., Schüssler, F., Sciutto, S. J., Scuderi, M., Segreto, A., Selmi-Dei, D. Pakk, Semikoz, D., Settimo, M., Shellard, R. C., Sidelnik, I., Siffert, B. B., Sigl, G., Smith, B. E., Snow, G. R., Sommers, P., Sorokin, J., Spinka, H., Squartini, R., Strazzeri, E., Stutz, A., Suarez, F., Suomijärvi, T., Supanitsky, A. D., Sutherland, M. S., Swain, J., Szadkowski, Z., Sánchez, F., Tamashiro, A., Tamburro, A., Tarutina, T., Taşcău, O., Tcaciuc, R., Tcherniakhovski, D., Tegolo, D., Thao, N. T., The Pierre Auger Collaboration, Thomas, D., Ticona, R., Tiffenberg, J., Timmermans, C., Tkaczyk, W., Tomé, B., Tonachini, A., Torres, I., Travnicek, P., Tridapalli, D. B., Tristram, G., Trovato, E., Tueros, M., Ulrich, R., Unger, M., Urban, M., Valiño, I., Valore, L., VandenBerg, A. M., Veberič, D., Velarde, A., Venters, T., Verzi, V., Videla, M., Villaseñor, L., Vorobiov, S., Voyvodic, L., Vázquez, J. R., Vázquez, R. A., Wahlberg, H., Wahrlich, P., Wainberg, O., Warner, D., Watson, A. A., Westerhoff, S., Whelan, B. J., Wieczorek, G., Wiencke, L., Wilczyńska, B., Wilczyński, H., Wileman, C., Winnick, M. G., Wu, H., Wundheiler, B., Yamamoto, T., Younk, P., Yuan, G., Yushkov, A., Zas, E., Zavrtanik, D., Zavrtanik, M., Zaw, I., Zepeda, A., Ziolkowski, M., Śmiałkowski, A., Šmída, R. +471 morecore Repeated intradermal lipopolysaccharide challenge responses in healthy volunteers: Implications for clinical pharmacology studies
British Journal of Clinical Pharmacology, EarlyView.Aim
Intradermal application of lipopolysaccharide (LPS), a Toll‐like receptor 4 agonist, induces a local inflammatory response and is used as a human challenge model to evaluate the pharmacodynamics of investigational medicinal products. While currently applied in a single, parallel‐group setting, alternative within‐subject designs involving repeated ...Alexandra A. J. Sillé, Juliette A. van den Noort, Iva Lelios, Diana R. Pereira, Marzia A. Scelsi, Erica S. Klaassen, Philipp Schoenenberger, Naomi B. Klarenbeek, Pierre‐Eric Juif, Pascal Espie, Manon A. A. Jansen, Matthijs Moerland, Richard W. D. Welford +12 morewiley +1 more sourceNeuronal differentiation and tissue engineering strategies for central neurous system injury repair
BMEMat, EarlyView.This review outlines tissue engineering advances for central nervous system (CNS) injury treatment, focusing on three core components: seed cells, inductive factors, and scaffold materials, with evaluation of their respective strengths and limitations. Tissue engineering for CNS injury repair.Zhuqing Xia, Jinghui Zhang, Na Ren, Shuping Wang, Congcong Zhang, Nik Ahmad Nizam Nik Malek, Wan Hairul Anuar Kamaruddin, Chao Liu, Chunhui Sun, Jingang Wang +9 morewiley +1 more sourceA roadmap to key traits of invasive Drosophilidae
Biological Reviews, EarlyView.ABSTRACT
Biological invasions have intensified in recent decades, mostly driven by international trade and travel, raising significant concerns, particularly regarding insect pests. Once non‐native species establish, they can disrupt natural ecosystem stability, undermine agroecosystem sustainability and cause substantial economic losses.Gwenaëlle Deconninck, Bréa Raynaud‐Berton, Méghan Boulembert, Olivier Chabrerie, Aude Couty, Franck Dedeine, Patrice Eslin, Vincent Foray, Romain Georges, Patricia Gibert, Laurence Mouton, Sylvain Pincebourde, David Renault, Christelle Suppo, Hervé Colinet +14 morewiley +1 more source
