Results 231 to 240 of about 77,765 (343)

GRKs and arrestins: Nomenclature and functions in GPCR‐dependent and ‐independent signalling

British Journal of Pharmacology, Volume 183, Issue 11, Page 2619-2633, June 2026.
G protein‐coupled receptor (GPCR) kinases (GRKs) and arrestins play a critical role in the regulation of GPCR signalling. Historic names of mammalian GRKs were replaced by systematic ones in the 1990s; however, both kinds of names are currently in use for mammalian arrestins.
Vsevolod V. Gurevich
wiley   +1 more source

Imaging cystoid macular oedema secondary to branch retinal vein occlusion with spectral domain optical coherence tomography: A case report. [PDF]

SAGE Open Med Case Rep
Kumaran SL, Renuga Sri GK, Esther Thomas B, Selvister SM.   +3 more
europepmc   +1 more source

Mitochondrial DNA: A Key Alarmin Igniting the Inflammasome Fire in Health and Disease

Immunology, Volume 178, Issue 2, Page 218-230, June 2026.
This review illustrates how mitochondrial DNA, released under cellular stress, acts as a key alarmin that ignites innate immune sensors, particularly inflammasomes and the cGAS‐STING pathway. This paper details how this sustained “inflammasome fire” fuels the progression of diverse inflammatory diseases, including neurodegeneration and metabolic ...
Woo Hyun Park
wiley   +1 more source

Severe Polypoidal Choroidal Vasculopathy as a Harbinger of Spontaneous Suprachoroidal Hemorrhage. [PDF]

J Vitreoretin Dis
Tao BK, Pereira A, Gemae M, Bakshi N, Tang T, Christakis P, Cruz-Pimentel M, Yan P.   +7 more
europepmc   +1 more source

Porcine Single-Eye Retinal Pigment Epithelium Cell Culture for Barrier and Polarity Studies

Philipp Dörschmann, Sina von der Weppen, Emi Koyama, Johann Roider, Alexa Klettner   +4 more
openalex   +1 more source

Specific Assay Protocols for Porcine Single-Eye Retinal Pigment Epithelium Concerning Oxidative Stress and Inflammation [PDF]

Philipp Dörschmann, Marco Prinz, Greta Schmitkall, Johann Roider, Alexa Klettner   +4 more
openalex   +1 more source

Dual Knockout Models of the Spatially and Functionally Conserved rgra and rgrb Zebrafish Genes Reveal the Requirement of RGR for the Integrity of Cone‐Mediated Photopic Vision, the Photopic Visual Cycle and Bruch's Membrane Morphology

The FASEB Journal, Volume 40, Issue 10, 31 May 2026.
This study investigates the role of the vision gene RGR using novel dual knockout zebrafish models. The loss of rgra and rgrb results in zebrafish larvae having reduced visual function and altered retinoid profiles under light but not dark conditions. The OKR phenotype is enhanced under higher light intensities.
Grace Ruddin, Tess McCann, Joanna J. Kaylor, Michelle M. Fox, John D. Fehilly, Rebecca Ward, Adam Faulkner, Ailís L. Moran, Kieran Wynne, Roxana A. Radu, Michael G. Monaghan, Stephen D. Thorpe, Gabriel H. Travis, Breandán N. Kennedy   +13 more
wiley   +1 more source

Postmortem Retinal Structural and Metabolic Analysis After Human Embryonic Stem Cell-derived Retinal Pigment Epithelium Transplantation in a Patient With Stargardt Disease. [PDF]

J Vitreoretin Dis
Kesavamoorthy N, Saber MS, Su E, Junge JA, Rao N, Ameri H.   +5 more
europepmc   +1 more source

Single-Eye Porcine Retinal Pigment Epithelium Cell Cultures—A Validated and Reproducible Protocol [PDF]

Philipp Dörschmann, Justine Wilke, Nina Tietze, Johann Roider, Alexa Klettner   +4 more
openalex   +1 more source

Metformin promotes mitochondrial integrity through AMPK‐signaling in Leber's hereditary optic neuropathy

FEBS Open Bio, Volume 16, Issue 5, Page 885-905, May 2026.
Metformin mediates mitochondrial quality control in Leber's hereditary optic neuropathy (LHON) fibroblasts carrying mtDNA mutations. At therapeutic levels, metformin activates AMPK signaling to restore mitochondrial dynamics by promoting fusion and restraining fission, while preserving mitochondrial mass, enhancing autophagy/mitophagy and biogenesis ...
Chatnapa Panusatid, Rapasviranda Soiyangsuk, Maneeluck Tanadjindarat, Chayanon Peerapittayamongkol   +3 more
wiley   +1 more source