Results 121 to 130 of about 2,826,109 (303)

Light-induced depigmentation in planarians models the pathophysiology of acute porphyrias

eLife, 2016
Porphyrias are disorders of heme metabolism frequently characterized by extreme photosensitivity. This symptom results from accumulation of porphyrins, tetrapyrrole intermediates in heme biosynthesis that generate reactive oxygen species when exposed to ...
Bradford M Stubenhaus, John P Dustin, Emily R Neverett, Megan S Beaudry, Leanna E Nadeau, Ethan Burk-McCoy, Xinwen He, Bret J Pearson, Jason Pellettieri   +8 more
doaj   +1 more source

A Rare De Novo Missense Mutation in IFT122 Confers a Genetic Susceptibility Factor of Idiopathic Pediatric Uveitis Via Trio‐based Whole‐Exome Sequencing

Advanced Science, EarlyView.
A rare de novo IFT122‐A773E variant is identified in idiopathic pediatric uveitis and shown to exacerbate retinal inflammation and barrier dysfunction. Mechanistically, the variant enhances IFT43 interaction, elevates calcium signaling, and activates the MEK/ERK/FRA1 axis, revealing a previously unrecognized cilia‐associated pathway that may increase ...
Qian Zhou, Jiaxing Huang, Yilin Wang, Xingran Li, Xianyang Liu, Lingyu Dai, Hongshun Li, Qingfeng Wang, Jiangyi Liu, Guannan Su, Wanyun Zhang, Yang Deng, Qingfeng Cao, Yujie Lai, Xiang Luo, Changwei Huang, Ling Chen, Shengping Hou, Peizeng Yang   +18 more
wiley   +1 more source

Pigment identification on Campana reliefs from the Palatine Hill and Colosseum Valley in Rome

, 2019
This article shows the first pigment identification of the Campana reliefs, Roman architectural earthenware plaques. The Campana reliefs polychromy were investigated by applying a multidisciplinary approach involving non-invasive and micro-destructive ...
Pronti L, Lorenzetti EG, Tarquini O, Felici AC   +3 more
core   +1 more source

Maximizing Biomass Production and Carotenoid-like Pigments Yield in Kocuria sediminis As04 Through Culture Optimization

Microorganisms
The global chemical pigment industry faces environmental challenges despite its economic importance. This study investigates the potential of Kocuria sediminis AS04, an airborne isolate, for sustainable pigment and biomass production.
Daniela Jakeline López-Mora, Andrea Goreti Flores-Dávalos, Miguel Angel Lorenzo-Santiago, Beatriz Genoveva Guardado-Fierros, Jacobo Rodriguez-Campos, Silvia Maribel Contreras-Ramos   +5 more
doaj   +1 more source

m6A‐Driven Pexophagy Triggers Placental Ferroptosis to Impair Fetal Growth Upon Environmental Stress

Advanced Science, EarlyView.
Prenatal environmental stress exposure promotes m6A modification to drive PEX2‐dependent pexophagy, thereby causing placental ferroptosis and FGR. ABSTRACT The role and underlying mechanisms of placental ferroptosis in fetal growth restriction (FGR) induced by environmental stress remain poorly understood.
Xin‐Xin Zhang, Ye‐Xin Luo, Cheng‐Fang Sun, Rui Pan, Yu‐Xi Wu, Zhi Yuan, Xin‐Run Wang, Xu‐Dong Zhang, Lan‐Lan Wu, Xiang‐Yu Yao, Zhan‐Dong Song, Wei Chang, Tian Wei, Pan‐Yuan Cai, Tian‐Ci Zhang, Yong‐Wei Xiong, De‐Xiang Xu, Hua Wang, Hua‐Long Zhu   +18 more
wiley   +1 more source

The Transformation of Pigment in Fruit Wine, Precise Control of Pigment Formation, and Their Effect on Product Quality

Foods
Global fruit production is excessive, and fruit wine is a significant outcome of fruit processing. The pigment in fruit wine gives it a vibrant color and affects its quality, taste, and marketing.
Xiang Tan, Mengfan Ding, Chen Wang, Linhua Huang, Junying Bai   +4 more
doaj   +1 more source

Single‐Cell Profiling Reveals a Protective WNT5A‐ATF3‐FOSB Signaling Axis in Hair Follicle Stem Cells During Androgenetic Alopecia

Advanced Science, EarlyView.
Androgenetic alopecia (AGA) is a common form of hair loss with limited treatment options. Silencing of WNT5A signaling, which is widely known as the trigger of the ncWNT signaling pathway, happens in hair follicle stem cells from balding areas. It leads to downregulation of ATF3 and its target FOSB.
Ruiyu Luo, Ke Fang, Changjiang Zhao, Jiachao Xiong, Yuan Zhu, Mingyang Lu, He Yan, Zihan Li, Baojin Wu, Hua Jiang, Yufei Li   +10 more
wiley   +1 more source

Dual‐line Genome‐scale CRISPR Screening Enables Robust Target Gene Discovery

Advanced Science, EarlyView.
A species‐optimized CRISPR platform integrates efficient piggyBac delivery, genome‐scale sgRNA libraries, and parallel screening in two independently engineered Bactrocera dorsalis Cas9 cell lines. Cross‐line consensus analysis filters line‐specific effects, enriches candidates with reproducible in vivo phenotypes, and reveals conserved, species ...
Ziniu Li, Jiao Qiao, Qiuyuan Zhang, Peipei Liu, Chenjun Zheng, Qi Zhou, Mengqi Ji, Zhihui Zhu, Xiaoxue Li, Hongyu Zhang   +9 more
wiley   +1 more source

Encapsulated Leptin‐Producing Cells Facilitate Entrainment of Circadian Rhythms in Rodents and Nonhuman Primates

Advanced Science, EarlyView.
A clinically translatable cell line can be engineered to produce leptin, encapsulated in biomaterial and safely implanted to produce and deliver the metabolic regulating protein within the body. Implantation of these encapsulated cells decreases the time it takes for mice and non‐human primates to adjust to circadian disruptions similar to those ...
Samantha T. Fleury, Xuanyi Lin, Peter D. Rios, Christopher Olker, Eun Joo Song, Alejandra Cobos Perez, Cody Fell, Daisy Lopez, Ira Joshi, Hafsa Nasir, Cecelia Curtis, Danna Muringi, Kaiyuan Wang, José Oberholzer, Fred W. Turek, Isaac B. Hilton, Jonathan Rivnay, Martha Hotz Vitaterna, Omid Veiseh   +18 more
wiley   +1 more source

Pigment-depletion in Atlantic salmon (Salmo salar) post-smolt starved at elevated temperature is not influenced by dietary carotenoid type and increasing α-tocopherol level

, 2019
Pigment-depletion in the fillets of farmed Atlantic salmon (Salmo salar) arises after periods of elevated water temperatures with voluntary starving. This study tested the effects of dietary pre-loading with different pigment carotenoids (astaxanthin and/
Martin Grunenwald (15434030), Christopher Carter (14733268), Verlhac-Trichet, V (15703235), David Nichols (14745454), Schierle, J (15703238), Louise Adams (14730010), Mark Adams (14730013), Koppe, W (15703232)   +7 more
core