Engineering Biology Beyond Single Genes: Advances and Challenges in Multiplex Genome Editing
Multiplex genome editing is transforming genome engineering from single‐gene perturbation to network‐level control, yet its broader application remains limited by challenges in gRNA array engineering, delivery technologies, and safety management. Emerging AI‐driven approaches are accelerating guide RNA design and CRISPR effector optimization for ...
Linli Wang, Yongbin Liu, Hongbing Han
wiley +1 more source
Visible Spectral, CIELAB and Putative Chromophore-Class Screening of Plant and Agro-Food Residue Extracts. [PDF]
Masanet Martí J +5 more
europepmc +1 more source
Investigating Pompeii Subsoil Using Geomatics and Geophysics Merged Analyses
ABSTRACT The archaeological site of Pompeii represents an exceptional context for the application of non‐invasive and integrated investigation methods aimed at enhancing the understanding of both exposed and buried remains. This study presents the results of multidisciplinary research conducted in the Palestra Grande site, a large and strategically ...
Valentina Santoro +9 more
wiley +1 more source
Effects of nitrogen concentration on growth, fucoxanthin production, and fatty acid composition of the marine diatom <i>Nitzschia</i> sp. [PDF]
Amenorfenyo DK +7 more
europepmc +1 more source
Objective To characterize the clinical, immunologic, and proteomic changes associated with CD19 chimeric antigen receptor T cell therapy in patients with progressive systemic sclerosis (SSc). Methods Patients with progressive SSc received CD19 chimeric antigen receptor (CAR)‐T cell therapy and were observed longitudinally for safety, clinical efficacy,
Chenhan Jia +16 more
wiley +1 more source
Bioactivity and textile dyeing potential of pigments produced by Arcopilus cupreus T8. [PDF]
Che-Alee N +2 more
europepmc +1 more source
Investigating the changes in skin color representation within US medical textbook imagery
Abstract Medical education traditionally relies on textbooks with limited representation of dark skin tones, contributing to “visual racism.” This study sought to answer: “To what extent has skin‐of‐color representation changed in widely used U.S. medical textbooks over twenty years?” Older and newer editions of four widely used medical textbooks were ...
Justin Lyon +4 more
wiley +1 more source
Advances in Betalain Biosynthesis and Metabolic Engineering for Sustainable Natural Pigment Production. [PDF]
Monisha S +3 more
europepmc +1 more source
Anatomy Museum: An educational resource for community anatomy education
Abstract University Community Outreach Programs play an important role in the education of Health Sciences students by providing experiences that extend beyond traditional classroom learning and strengthen the integration between teaching, research, and social engagement.
Ticiana Sidorenko de Oliveira Capote +6 more
wiley +1 more source
Video‐Assisted Intralesional Curettage for Invasive Nonmalignant Giant Cell Tumors
Abstract Giant cell tumor of bone is a locally aggressive benign neoplasm with a strong tendency for local recurrence after surgical treatment. Intralesional excision and curettage is preferred in most cases to maximize tumor removal while preserving the affected joint.
George Loria +5 more
wiley +1 more source

