Results 181 to 190 of about 2,960,448 (354)

Exploring Bioactive Metabolites From Fusarium falciforme and Aspergillus terreus Isolated From Protease‐Rich Fruits: Antifungal, Antitrypanosomal, and Enzymatic Inhibitory Activities

Chemistry &Biodiversity, EarlyView.
Metabolites from fungi isolated from protease rich‐fruits displayed antifungal, antitrypanosomal and enzymatic inhibitory activities. ABSTRACT Fungal secondary metabolites display remarkable chemical diversity and biological potential, with applications in agriculture and pharmaceuticals. This study isolated and characterized bioactive metabolites from
Gabriela de Oliveira Almeida, Vitor de Souza Mazucato, Ludmilla Tonani, Marcia Regina von Zeska Kress, Gisele Barbosa, Renata Krogh, Adriano Defini Andricopulo, Leonardo Luiz Gomes Ferreira, Paulo Cezar Vieira   +8 more
wiley   +1 more source

Efficacy and Safety of Ruxolitinib Cream in Vitiligo by Patient Characteristic Subgroups: Descriptive Pooled Analysis From Two Phase 3 Studies

Dermatology and Therapy
Introduction Two phase 3 trials (TRuE-V1 and TRuE-V2) demonstrated that a topical formulation of the Janus kinase (JAK) 1/JAK2 inhibitor ruxolitinib significantly improved repigmentation versus vehicle cream in adolescent and adult patients with vitiligo.
Julien Seneschal, Albert Wolkerstorfer, Seemal R. Desai, Pearl Grimes, Khaled Ezzedine, Amit G. Pandya, Deanna Kornacki, Shaoceng Wei, Thierry Passeron, David Rosmarin   +9 more
doaj   +1 more source

Soluble Ring‐Unsubstituted Phthalocyanine Zirconium(IV) and Niobium(V) cis‐Alkoxides and Their Catalytic Activity Toward the Ring‐Opening Polymerization of rac‐Lactide

Chemistry – A European Journal, EarlyView.
Ring‐unsubstituted phthalocyanine chloride complexes of Zr(IV) and Nb(V) are solubilized via conversion to a range of cis‐axially ligated alkoxides, which show varying levels of activity as lactide polymerization catalysts depending on the alkoxide and the metal center.
Yumeela Ganga‐Sah, Simon Cassegrain, Wen Zhou, Thomas E. Karpiuk, Carys L. Kenny‐Howell, Steven Holdcroft, Daniel B. Leznoff   +6 more
wiley   +1 more source

Local sensitivity analysis of a supercritical extraction model

The Canadian Journal of Chemical Engineering, EarlyView.
Abstract This study investigates the process of chamomile oil extraction from chamomile flowers. A parameter‐distributed model, consisting of a set of partial differential equations, was used to describe the governing mass transfer phenomena between solid and fluid phases under supercritical conditions using carbon dioxide as the solvent.
Oliwer Sliczniuk, Pekka Oinas
wiley   +1 more source

PLK4: Master Regulator of Centriole Duplication and Its Therapeutic Potential

Cytoskeleton, EarlyView.
ABSTRACT Centrosomes catalyze the assembly of a microtubule‐based bipolar spindle, essential for the precise chromosome segregation during cell division. At the center of this process lies Polo‐Like Kinase 4 (PLK4), the master regulator that controls the duplication of the centriolar core to ensure the correct balance of two centrosomes per dividing ...
Muhammad Hamzah, Franz Meitinger, Midori Ohta   +2 more
wiley   +1 more source

McCune Albright Syndrome (MAS) : polyostotic fibrous dysplasia [PDF]

, 2017
Augsburg, Lukasz, Gielen, Jan, Vanhoenacker, Filip   +2 more
core   +2 more sources

Influence of environment and mineralogy on euendolithic microboring patterns

The Depositional Record, EarlyView.
Field experiments at Little Ambergris Cay reveal that euendolithic microorganisms preferentially bore carbonate substrates based on mineralogy, sea water saturation and trace metal content. Results highlight night‐time dissolution activity and mineralogical preferences, shedding light on the ecological and evolutionary drivers of bioerosion and their ...
Tyler Lincoln, Usha Lingappa, Brianna Hibner, Elizabeth J. Trower   +3 more
wiley   +1 more source

Redefining the Skin Barrier: A Microbiome‐Integrated Multilayered Defense Model

Barrier Immunity, EarlyView.
ABSTRACT The skin constitutes a dynamic interface orchestrating a sophisticated multilayered defense system comprising physical, chemical, immune, and microbial barriers. This review synthesizes current understanding of the structural and functional integration of these barriers, emphasizing their synergistic interactions in maintaining cutaneous ...
Jingjing Xia, Mathias Hochgerner, Qingzhen Wei, Xian'ge Zhong, Jiucun Wang   +4 more
wiley   +1 more source

CAQ Corner: Immune‐mediated complications

, 2022
Liver Transplantation, EarlyView.
Mary Thomson, John R. Lake
wiley   +1 more source

Uric Acid‐Lowering and Anti‐Hyperuricemia Effects of Plant‐Based Nutraceuticals and Foods: A Review

Food Chemistry International, EarlyView.
Increased UA production and/or decreased UA secretion cause hyperuricemia. Effects and mechanism of flavonoids in reducing UA are summarized. Terpenoids, saponins, alkaloids, vitamin C, polysaccharides, peptides are effective. Plant‐based foods with UA‐lowering ability are reviewed.
Linwei He, Wenjian Yang, Jianhui Liu
wiley   +1 more source