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Characterization of mouse melanocytes reveals ultrastructural and immunological insights into the inner ear function [PDF]
Communications BiologyMelanocytes are important components of the inner-ear cellular architecture. However, limited morphological research hinders our understanding of inner-ear function.
Jing Cai +13 more
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Novel uveal Melanocyte cell lines display distinct features from uveal melanoma [PDF]
Advances in Ophthalmology Practice and ResearchPurposes: Despite advances in prognostication for uveal melanoma (UM), mortality from this disease remains high due to a lack of effective treatments to prevent metastatic progression.
Lauren A. Dalvin +7 more
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PAX2 regulates ADAM10 expression and mediates anchorage-independent cell growth of melanoma cells [PDF]
, 2011 PAX transcription factors play an important role during development and carcinogenesis. In this study, we investigated PAX2 protein levels in melanocytes and melanoma cells by Western Blot and immunofluorescence analysis and characterized the role of ...
Lee, Sophia Boyoung +11 more
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BRN2 is a non-canonical melanoma tumor-suppressor
Nature Communications, 2021 The transcription factor BRN2 regulates melanoma migration and invasion, but its role during melanoma initiation is unclear. Here the authors show that BRN2 is a haplo-insufficient tumour suppressor that positively regulates PTEN expression and in the ...
Michael Hamm +23 more
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Molecular Cancer, 2021 Resistances to immunotherapies remains a major hurdle towards a cure for melanoma in numerous patients. An increase in the mesenchymal phenotype and a loss of differentiation have been clearly associated with resistance to targeted therapies.
Yann Cheli +14 more
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Molecular Cancer, 2021 An amendment to this paper has been published and can be accessed via the original article.
Yann Cheli +14 more
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Cutaneous and uveal melanoma: two different cancers in therapeutic needs
Comptes Rendus Biologies, 2021 Melanocytes are located in various parts of the human body, such as the skin and the eye. Their transformation leads to melanoma, an aggressive and deadly neoplasm.
Bertolotto, Corine
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A role for Dynlt3 in melanosome movement, distribution, acidity and transfer
Communications Biology, 2021 Aktary et al. identify novel roles for the dynein light chain Dynlt3 in melanosome transport, maturation, and transfer to keratinocytes. They also find that the Wnt/βcatenin signalling pathway controls Dynlt3 levels and thus also contributes to the ...
Zackie Aktary +9 more
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Cells, 2022 Melanocytes produce melanin to protect the skin from UV-B radiation. Notwithstanding, the spectrum of their functions extends far beyond their well-known role as melanin production factories.
Yan-Yan Chen +4 more
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Stem Cell Research & Therapy, 2023 Background Melanocytes are an essential part of the epidermis, and their regeneration has received much attention because propagation of human adult melanocytes in vitro is too slow for clinical use.
Chie Kobori +10 more
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