Results 41 to 50 of about 55,028 (307)

signaling in normal human melanocytes [PDF]

, 2015
Pleiotrophin (PTN) is a secreted heparin-binding protein that is involved in various biological functions of cell growth and differentiation. Little is known about the effects of PTN on the melanocyte function and skin pigmentation.
Park, JY, Tae Jun Park, Choi, WJ, Woo Jong Choi, Ji‐Youn Park, Hee Young Kang, Misun Kim, Kang, HY, Kim, M, Park, TJ   +9 more
core   +1 more source

Decrypting the Potential of Nanotechnology-Based Approaches as Cutting-Edge for Management of Hyperpigmentation Disorder

Molecules, 2022
The abundant synthesis and accretion of melanin inside skin can be caused by activation of melanogenic enzymes or increase in number of melanocytes. Melasma is defined as hyperpigmented bright or dark brown spots which are symmetrically distributed and ...
Sukhbir Singh, Neelam Sharma, Ishrat Zahoor, Tapan Behl, Anita Antil, Sumeet Gupta, Md Khalid Anwer, Syam Mohan, Simona Gabriela Bungau   +8 more
doaj   +1 more source

Herb Sanqi-Derived Compound K Alleviates Oxidative Stress in Cultured Human Melanocytes and Improves Oxidative-Stress-Related Leukoderma in Guinea Pigs

Cells, 2021
Sanqi, a traditional Chinese herb, is widely used for cardiovascular diseases, and its neuroprotective effects against oxidative stress were recently discovered. The purpose of this study was to investigate whether Sanqi-derived compound K (Sanqi-CK), an
Suwei Tang, Lingli Yang, Yasutaka Kuroda, Sylvia Lai, Shaoqiong Xie, Huimin Zhang, Ichiro Katayama   +6 more
doaj   +1 more source

CD44 Expression on Epidermal Melanocytes [PDF]

, 1996
We examined CD44 expression on melanocytes to begin to understand what role CD44 might have in the normal behavior of melanocytes and to provide a basis for comparing CD44 expression in melanoma cells.
Haggerty, John G., Leonard M. Milstone, Zhou, Jing, Milstone, Leonard M., John G. Haggerty, Jing Zhou, Herbold, Kyle W., Kyle W. Herbold   +7 more
core   +1 more source

Mesenchymal stem cells promote human melanocytes proliferation and resistance to apoptosis through PTEN pathway in vitiligo

Stem Cell Research & Therapy, 2020
Background Vitiligo is an acquired chronic and recurrent skin disease that causes a depigmentation disorder, resulting in selective destruction of melanocytes (MC).
Lifei Zhu, Xi Lin, Lin Zhi, Yushan Fang, Keming Lin, Kai Li, Liangcai Wu   +6 more
doaj   +1 more source

Proteasomal degradation of intracellularly expressed Amblyomin‐X limits suicide gene therapy potential in melanoma cells

FEBS Open Bio, EarlyView.
This study explores the feasibility of expressing the antitumoral protein Amblyomin‐X through a suicide gene therapy approach and investigates its intracellular fate after gene delivery. Although the gene is efficiently expressed, melanoma cells rapidly degrade the Amblyomin‐X protein via proteasome activity.
Victor Dal Posolo Cinel, Carlos DeOcesano Pereira, Aline Ramos Maia Lobba, Melissa Regina Fessel, Ana Marisa Chudzinski‐Tavassi   +4 more
wiley   +1 more source

An in vitro investigation into the pigmentary phenotype of melanocytes and keratinocyte co-cultures to improve wound healing [PDF]

, 2013
Includes abstract.Includes bibliographical references.On healing, partial-thickness burn wounds usually result in depigmentation of the skin. This is due to the loss of melanocytes.
Chang, Ju-Wei
core  

Imbalance of the antioxidant pool in malignant melanocytes and in normal melanocytes from melanoma patients. [PDF]

, 1996
In order to evaluate the free radical defense systems of melanocytes and their possible correlation with melanoma, we have studied in cultured normal human melanocytes (20), normal melanocytes from melanoma patients (15), and melanoma cells (40) the ...
DEL PORTO, Giuseppe, ROCCELLA M, ROCCELLA F, GRAMMATICO, Paola, PICARDO M, PASSI S., GRANDINETTI M   +6 more
core   +1 more source

A Novel Perfused Full‐Thickness Human Skin Microphysiological System for Modeling Injury, Regeneration, Tumor Pathophysiology, and Therapeutics Development

Advanced Healthcare Materials, EarlyView.
What if human skin could remain fully alive and functional outside the body for weeks? A New Alternative Method (NAM) based on a vascularized full‐thickness skin microphysiological system achieves precisely this, preserving native vasculature, resident immunity, and metabolic activity for up to three weeks, while faithfully recapitulating radiation ...
Yusuf Surucu, Hamid Malekzadeh, Alexa Rivera Del Rio Hernandez, Naresh Mahajan, Ethan Banks, Dayyan Ur Rahman, José A. Arellano, Katherine S. Yang, Alexey Altman, G.V. Naveen Kumar, Matthew L. Steinhauser, Jeffrey A. Gusenoff, J. Peter Rubin, Asim Ejaz   +13 more
wiley   +1 more source

The genomic landscapes of individual melanocytes from human skin [PDF]

, 2020
Every cell in the human body has a unique set of somatic mutations, but it remains difficult to comprehensively genotype an individual cell1. Here we describe ways to overcome this obstacle in the context of normal human skin, thus offering a glimpse ...
Shain, A Hunter, Yeh, Iwei, McNeal, Andrew S, Tang, Jessica, Tan, Tuyet M, Fewings, Eleanor, Arron, Sarah T, Chang, Darwin, Jorapur, Aparna, Liu, Shanshan, Belote, Rachel L, Zeng, Hanlin, Judson-Torres, Robert L, Bastian, Boris C   +13 more
core   +1 more source