Results 41 to 50 of about 60,667 (308)

Imiquimod induces apoptosis of human melanocytes.

, 2010
Development of vitiligo-like hypopigmentary lesions associated with topical imiquimod has been reported. We hypothesized that mode of action of imiquimod in melanocytes may include triggering of apoptosis resulted in loss of cells, which may be a ...
Joo Hee Ahn, Jung Hee Pyun, Kang, SU, Lee, MH, Pyun, JH, Chul-Ho Kim, Hye Sook Hwang, Mi Hye Lee, Ahn, JH, Hwang, HS, Sung Un Kang, Kim, CH, Hee Young Kang, Kang, HY   +13 more
core   +1 more source

Targeting anti-apoptotic pathways eliminates senescent melanocytes and leads to nevi regression [PDF]

, 2022
Human melanocytic nevi (moles) result from a brief period of clonal expansion of melanocytes. As a cellular defensive mechanism against oncogene-induced hyperplasia, nevus-resident melanocytes enter a senescent state of stable cell cycle arrest ...
Ge, Chen, Ge, Chen; id_orcid, Brandenburg, Simone M., Kohli, Jaskaren, Fitsiou, Eleni, Demaria, Marco, Brandenburg, Simone M.; id_orcid, Demaria, Marco; id_orcid, Doepner, Miriam, Ridky, Todd W., Faller, William J., Marco Demaria, William J. Faller, Miriam Doepner, Chen Ge, Jaskaren Kohli, Eleni Fitsiou, Simone M. Brandenburg, Todd W. Ridky   +18 more
core   +1 more source

Single‐Cell Profiling Reveals a Protective WNT5A‐ATF3‐FOSB Signaling Axis in Hair Follicle Stem Cells During Androgenetic Alopecia

Advanced Science, EarlyView.
Androgenetic alopecia (AGA) is a common form of hair loss with limited treatment options. Silencing of WNT5A signaling, which is widely known as the trigger of the ncWNT signaling pathway, happens in hair follicle stem cells from balding areas. It leads to downregulation of ATF3 and its target FOSB.
Ruiyu Luo, Ke Fang, Changjiang Zhao, Jiachao Xiong, Yuan Zhu, Mingyang Lu, He Yan, Zihan Li, Baojin Wu, Hua Jiang, Yufei Li   +10 more
wiley   +1 more source

The nature of miniature melanocytes in murine epidermis [PDF]

, 1973
In the epidermis of PET/Wmr mice the population of melanocytes reaches a peak and begins to decline during the first postnatal week, and has disappeared within four weeks.
Earnhardt, John Thomas
core   +1 more source

Differentiation of cultured hair follicle neural crest stem cells into functional melanocytes

Heliyon
Many autologous melanocytes are required for surgical treatment of depigmentation diseases such as vitiligo. However, primary cultured melanocytes have a limited number of in vitro passages.
Hongjuan Wang, Wen Hu, Fang Xiang, Zixian Lei, Xiangyue Zhang, Jingzhan Zhang, Yuan Ding, Xiaojing Kang   +7 more
doaj   +1 more source

Mesenchymal stem cells promote human melanocytes proliferation and resistance to apoptosis through PTEN pathway in vitiligo

Stem Cell Research & Therapy, 2020
Background Vitiligo is an acquired chronic and recurrent skin disease that causes a depigmentation disorder, resulting in selective destruction of melanocytes (MC).
Lifei Zhu, Xi Lin, Lin Zhi, Yushan Fang, Keming Lin, Kai Li, Liangcai Wu   +6 more
doaj   +1 more source

Dual‐Targeting Biomimetic Nanozymes Loaded Microneedle Patch Promotes Scarless Wound Healing Through Anti‐Inflammatory and Anti‐Fibrotic Effects

Advanced Science, EarlyView.
This study developed a dual‐targeting biomimetic nanozyme hybrid system (Cu‐CeO2@ABs‐FTP) and integrated it with HAMA hydrogel to fabricate a microneedle patch (CAF@MN). The patch promotes fibroblast‐mediated wound repair, targets macrophages to induce M2 polarization, and targets myofibroblasts to exert anti‐fibrotic effects, thereby enabling rapid ...
Hongyi Zhang, Jinwei Li, Shan Hua, Shengming Wu, Chenlong He, Yuan Zhu, Ming Yin, Han Zhou, Huawei Liu, Chika Hasegawa, Jun Lyu, Keyue Xiao, Hua Jiang, Yilong Wang, Yuxin Qian   +14 more
wiley   +1 more source

Isolation, Culture, and Transfection of Melanocytes. [PDF]

, 2023
Located in the basal epidermis and hair follicles, melanocytes of the integument are responsible for its coloration through production of melanin pigments. Melanin is produced in a type of lysosome-related-organelle (LRO) called the melanosome. In humans,
Kohli, JS, Bennett, DC, Joanna T. Castle, Sviderskaya, EV, Elena V. Sviderskaya, Dorothy C. Bennett, Goff, PS, Jaskaren S. Kohli, Castle, JT, Philip S. Goff   +9 more
core   +1 more source

Potential of Nanoparticle‐Based Phototherapies for Future Treatment of Uveal Melanoma

Advanced Science, EarlyView.
This review evaluates nanoparticle‐based phototherapies for uveal melanoma, highlighting emerging strategies to enhance tumor targeting, light delivery, and treatment precision. Preclinical data indicate improved efficacy and reduced toxicity, supporting their potential to enhance localized treatment and future translational advances. (Generated by the
Emilie Lambert, Christophe Nguyen, Sean Edward Dunn, Magali Gary‐Bobo, Jérôme Lacombe, Justin Moser, Frédéric Zenhausern, Jean‐Olivier Durand, Frédérique Cunin   +8 more
wiley   +1 more source

The Assessment of Meloxicam Phototoxicity in Human Normal Skin Cells: In Vitro Studies on Dermal Fibroblasts and Epidermal Melanocytes

Molecules, 2022
Meloxicam (MLX), which belongs to the oxicam nonsteroidal anti-inflammatory drug derivatives, is an inhibitor of the cyclooxygenase-2 (COX-2) enzyme. Cutaneous adverse effects caused by interaction between UVA radiation and exogenous factors can manifest
Marta Karkoszka, Jakub Rok, Klaudia Banach, Justyna Kowalska, Zuzanna Rzepka, Dorota Wrześniok   +5 more
doaj   +1 more source