Results 51 to 60 of about 59,400 (251)
Advanced Science, EarlyView.Androgenetic alopecia (AGA) is a common form of hair loss with limited treatment options. Silencing of WNT5A signaling, which is widely known as the trigger of the ncWNT signaling pathway, happens in hair follicle stem cells from balding areas. It leads to downregulation of ATF3 and its target FOSB.
Ruiyu Luo +10 more
wiley +1 more source
Poultry Science: The presence of a significant number of melanocytes in the ovary and follicular membrane of Silky Fowl suggests their potential involvement in follicle development.
Yurong Tai +7 more
doaj +1 more source
The role of Rab27a in the regulation of melanosome distribution within retinal pigment epithelial cells [PDF]
, 2004 Melanosomes within the retinal pigment epithelium (RPE) of mammals have long been thought to exhibit no movement in response to light, unlike fish and amphibian RPE.
Seabra, MC +4 more
core
CD44 Expression on Epidermal Melanocytes [PDF]
, 1996 We examined CD44 expression on melanocytes to begin to understand what role CD44 might have in the normal behavior of melanocytes and to provide a basis for comparing CD44 expression in melanoma cells.
Haggerty, John G. +7 more
core +1 more source
Advanced Science, EarlyView.This study developed a dual‐targeting biomimetic nanozyme hybrid system (Cu‐CeO2@ABs‐FTP) and integrated it with HAMA hydrogel to fabricate a microneedle patch (CAF@MN). The patch promotes fibroblast‐mediated wound repair, targets macrophages to induce M2 polarization, and targets myofibroblasts to exert anti‐fibrotic effects, thereby enabling rapid ...
Hongyi Zhang +14 more
wiley +1 more source
Potential of Nanoparticle‐Based Phototherapies for Future Treatment of Uveal Melanoma
Advanced Science, EarlyView.This review evaluates nanoparticle‐based phototherapies for uveal melanoma, highlighting emerging strategies to enhance tumor targeting, light delivery, and treatment precision. Preclinical data indicate improved efficacy and reduced toxicity, supporting their potential to enhance localized treatment and future translational advances. (Generated by the
Emilie Lambert +8 more
wiley +1 more source
Advanced Science, EarlyView.BNC2 exhibits context‐dependent opposing functions across multiple cancer types. This study reveals BNC2 as an oncogenic driver of melanoma proliferation and metastasis through transcriptional activation of PIK3CA. The natural compound TSN simultaneously degrades BNC2 and its oncogenic partner SMAD3 via CRBN‐dependent ubiquitination.
Hui Dai +7 more
wiley +1 more source
Novel uveal Melanocyte cell lines display distinct features from uveal melanoma
Advances in Ophthalmology Practice and ResearchPurposes: Despite advances in prognostication for uveal melanoma (UM), mortality from this disease remains high due to a lack of effective treatments to prevent metastatic progression.
Lauren A. Dalvin +7 more
doaj +1 more source
Imiquimod induces apoptosis of human melanocytes.
, 2010 Development of vitiligo-like hypopigmentary lesions associated with topical imiquimod has been reported. We hypothesized that mode of action of imiquimod in melanocytes may include triggering of apoptosis resulted in loss of cells, which may be a ...
Joo Hee Ahn +13 more
core +1 more source
Nuclear IDH3A Drives Transcriptional Programs in Melanoma via the YBX1–JUN/FOS Axis
Advanced Science, EarlyView.Genomic amplification drives aberrant nuclear localization of IDH3A in melanoma. Independent of its canonical metabolic activity, nuclear IDH3A cooperates with YBX1 to activate the c‐JUN/c‐FOS transcriptional program, while NONO facilitates its nuclear localization.
Juan Ran +10 more
wiley +1 more source