Results 51 to 60 of about 54,942 (309)

Active Notch1 confers a transformed phenotype to primary human melanocytes

, 2009
The importance of mitogen-activated protein kinase signaling in melanoma is underscored by the prevalence of activating mutations in N-Ras and B-Raf, yet clinical development of inhibitors of this pathway has been largely ineffective, suggesting that ...
Liu, Zhao-Jun, Lee, John, Beverly, Levi, Brafford, Patricia, McDaid, Ronan, Zabierowski, Susan, Balint, Klara, Xiao, Min, Himes, Benjamin, Pollock, Pamela, Pinnix, Chelsea   +10 more
core   +1 more source

Streamlining Diagnosis of Bardet–Biedl Syndrome: New Diagnostic Algorithm With Updated Criteria

American Journal of Medical Genetics Part A, EarlyView.
ABSTRACT Considerable advances have been made in our understanding of Bardet–Biedl syndrome (BBS), particularly in its core clinical features and molecular genetics, warranting an update to the existing diagnostic criteria framework. Using a rigorous, evidence‐based, and consensus‐driven process, a multidisciplinary group of international experts and ...
Jeremy J. Pomeroy, Jesse Richards, Brooke R. Sweeney, Seema Kumar, Katie E. Queen, Joshua Zaritsky, Carl H. Cramer, Elias I. Traboulsi, Brittni A. Scruggs, Erica E. Davis, Ekaterina Keifer, Emma McGibbon, Timothy Ogden, Bendert De Graaf, Tonia Hymers, Elizabeth Forsythe, Philip Beales   +16 more
wiley   +1 more source

In vitro culture and tissue-derived specific expression of melanocytes from ovary of adult Silky Fowl

Poultry Science
: The presence of a significant number of melanocytes in the ovary and follicular membrane of Silky Fowl suggests their potential involvement in follicle development.
Yurong Tai, Deping Han, Xue Yang, Ganxian Cai, HuaiYu Li, Yuanyuan Zhang, Junying Li, Xuemei Deng   +7 more
doaj   +1 more source

Melanocytes, melanocyte stem cells, and melanoma stem cells [PDF]

Clinics in Dermatology, 2013
Melanocyte stem cells differ greatly from melanoma stem cells; the former provide pigmented cells during normal tissue homeostasis and repair, and the latter play an active role in a lethal form of cancer. These 2 cell types share several features and can be studied by similar methods.
Deborah, Lang, Joseph B, Mascarenhas, Christopher R, Shea   +2 more
openaire   +2 more sources

Developmental Biology of Mammalian Melanocytes

, 1980
The developmental biology of mammalian cutaneous melanocytes spans the entire life cycle from embryo to senescent adult. This review focuses on the inelanocytes of the epidermis.
Fleischmann, Robert D., Quevedo, Walter C.   +1 more
core   +1 more source

Electrocardiographic and Skin Manifestations of Turner Syndrome: Association With Cardiovascular Disease

American Journal of Medical Genetics Part A, EarlyView.
ABSTRACT Congenital heart disease (CHD) and dermatologic conditions such as lymphedema and acquired melanocytic nevi (AMN) are common in Turner Syndrome (TS). We hypothesized that abnormalities of cranial neural crest cell derivatives drive the skin and heart manifestations of TS. We conducted joint cardiac and skin examinations of volunteers at a 2023
Sarah Elsaim, Brett Vernier, Van Thi Thanh Truong, Riya T. Patel, Matthew Brown, Martin Chacon Portillo, Megan Rogge, David Rodriguez‐Buritica, Siddharth K. Prakash   +8 more
wiley   +1 more source

An Investigation of Autoantibodies against Tyrosine Hydroxylase in Patients with Vitiligo [PDF]

, 2012
Vitiligo is an acquired idiopathic hypomelanotic skin disorder characterised by depigmented macules due to loss of cutaneous melanocytes. Evidence suggests that autoimmunity plays a role in the pathogenesis of the disease, since antibodies and T cells ...
Rahoma, Sherif
core  

Genetic Diversity, Adaptation, Wild Introgression, and Coat Color Mutation of Golden Yak

Animal Research and One Health, EarlyView.
Genetic diversity, adaptation, wild introgression, and coat color mutation of golden yak from two populations on the Qinghai‐Xizang Plateau. ABSTRACT The golden yak lives on the Qinghai‐Xizang Plateau with a golden coat and adapts to high altitudes and strong ultraviolet environment. The golden coat is a prominent phenotype in many domesticated species,
Huixuan Yan, Jialei Chen, Chuzhao Lei, Fengwei Zhang, Shunzhong He, Weiru Song, Hongyan Ma, Shuling Li, Guomei Li, Laba Yongcuo, Jianlin Han, Johannes A. Lenstra, Qiang Zhang, Rende Song, Basang Wangdui, Ningbo Chen   +15 more
wiley   +1 more source

Imiquimod induces apoptosis of human melanocytes.

, 2010
Development of vitiligo-like hypopigmentary lesions associated with topical imiquimod has been reported. We hypothesized that mode of action of imiquimod in melanocytes may include triggering of apoptosis resulted in loss of cells, which may be a ...
Joo Hee Ahn, Jung Hee Pyun, Kang, SU, Lee, MH, Pyun, JH, Chul-Ho Kim, Hye Sook Hwang, Mi Hye Lee, Ahn, JH, Hwang, HS, Sung Un Kang, Kim, CH, Hee Young Kang, Kang, HY   +13 more
core   +1 more source

Human Fibroblast‐Myeloid cell tissue atlas across lung, synovium, skin and heart

Arthritis &Rheumatology, Accepted Article.
Background The availability of single‐cell RNA sequencing (scRNAseq data) in different tissues and disease states provides an opportunity to compare cellular subsets and identify common and unique cellular activation. In this study, we aimed to characterize shared and tissue‐specific myeloid and stromal phenotypes and to uncover key cellular subtypes ...
Lucy MacDonald, Katerina Apostolopoulou, Olympia Hardy, Melpomeni Toitou, Gabriela Kania, Przemyslaw Blyszczuk, Raphael Micheroli, Thomas D Otto, Mariola Kurowska‐Stolarska, Caroline Ospelt   +9 more
wiley   +1 more source