Results 61 to 70 of about 54,942 (309)

Melanocytes: A Window into the Nervous System

, 2012
Melanocytes are pigment-producing cells that originate from the dorsal portions of the closing neural tube in vertebrate embryos. Similar to neurons, they are derived from pluripotent neural crest cells that differentiate into numerous cell lineages. The
Hee-Young Park, Park, Hee-Young, Yaar, Mina, Mina Yaar   +3 more
core   +1 more source

Efficacy, safety and cost‐effectiveness of CAR‐T therapy

British Journal of Clinical Pharmacology, EarlyView.
CAR T‐cells demonstrate high efficacy in blood cancers, including ALL, MM and DLBCL. Innovations target solid tumours despite challenges such as antigen escape. Combination therapies enhance the delivery and infiltration of CAR T cells. Toxicity, cost and resistance remain major barriers to clinical use.
Emina Karahmet Sher, Amina Džidić‐Krivić, Emma Pinjic, Nejra Selak, Kanita Omerbasic, Alexandar Chupin, Andrej Belancic, Almir Fajkic   +7 more
wiley   +1 more source

Novel uveal Melanocyte cell lines display distinct features from uveal melanoma

Advances in Ophthalmology Practice and Research
Purposes: Despite advances in prognostication for uveal melanoma (UM), mortality from this disease remains high due to a lack of effective treatments to prevent metastatic progression.
Lauren A. Dalvin, Piotr K. Kopinski, David R. Miley, Hien Ong, Samantha A. Erickson, Cynthia M. Andrews-Pfannkoch, Stephanie D. Burr, James A. Armitage   +7 more
doaj   +1 more source

signaling in normal human melanocytes

, 2015
Pleiotrophin (PTN) is a secreted heparin-binding protein that is involved in various biological functions of cell growth and differentiation. Little is known about the effects of PTN on the melanocyte function and skin pigmentation.
Park, JY, Tae Jun Park, Choi, WJ, Woo Jong Choi, Ji‐Youn Park, Hee Young Kang, Misun Kim, Kang, HY, Kim, M, Park, TJ   +9 more
core   +1 more source

Neurovascular coupling in bone regeneration: Mechanisms, advanced biomaterials and challenges

BMEMat, EarlyView.
This figure illustrates various material strategies for neurovascularized bone regeneration, including electroactive scaffolds, ion‐loaded materials, drug delivery systems, surface modifications, cells/cell products, growth factors, and peptides. These approaches aim to synergistically promote the regeneration of neural, vascular, and bone tissues ...
Yixin Ma, Nan Jiang, Liyuan Chen, He Zhang, Xinjia Cai, Karan Gulati, Danqing He, Zhigang Cai, Yan Liu   +8 more
wiley   +1 more source

The Influence of Drosophila Spire and Myosin V During Mid‐Oogenesis Is Independent of Their Direct Interaction

Cytoskeleton, EarlyView.
ABSTRACT Cooperativity between cytoskeletal proteins is crucial for spatiotemporal coordination in biological processes, like oogenesis. In mammalian and Drosophila oogenesis, proper assembly and function of actin networks require coordination between actin assembly factors Spire and formins, as well as actin‐associated proteins like myosins and Rab ...
Joseph Y. Ong, Hannah M. Bailey, Emma Carley, Michelle Panzica, Merin Rixen, Neil Billington, Rong Liu, Margot E. Quinlan   +7 more
wiley   +1 more source

Hair follicle-derived melanocyte transplant as a promising treatment strategy for vitiligo

Stem Cell Research & Therapy
Background The global incidence of vitiligo has been increasing in recent years, imposing psychological distress and social pressure owing to its refractory and recurrent nature.
Ruirui Fan, Jie Gao, Jin Chen
doaj   +1 more source

CD44 Expression on Epidermal Melanocytes

, 1996
We examined CD44 expression on melanocytes to begin to understand what role CD44 might have in the normal behavior of melanocytes and to provide a basis for comparing CD44 expression in melanoma cells.
Haggerty, John G., Leonard M. Milstone, Zhou, Jing, Milstone, Leonard M., John G. Haggerty, Jing Zhou, Herbold, Kyle W., Kyle W. Herbold   +7 more
core   +1 more source

Novel Organelle‐Based Intracellular Immunity With Mechanistic and Therapeutic Implications

Barrier Immunity, EarlyView.
A conceptual framework illustrating how PAMPs/DAMPs initiate barrier, innate, adaptive, and intracellular immune responses, with organelle‐based intracellular immunity serving as a central integrator linking metabolism, inflammatory signaling, and therapeutic interventions to restore immune homeostasis.
Keman Xu, Shih‐Yu Hung, Fatma Saaoud, Ying Shao, Yifan Lu, Juanjuan Liu, Bo Yuan, Haiyan Xiang, Hong Wang, Xiaofeng Yang   +9 more
wiley   +1 more source

Re-appraisal of keratinocytes' role in vitiligo pathogenesis

Indian Journal of Dermatology, 2018
Background: Vitiligo is a common pigmentary disorder. Studies on its pathogenesis extensively investigated melanocytes' abnormalities and few studies searched for keratinocytes' role in disease development.
Ola Ahmed Bakry, Mohamed Abd El Moneim Shoeib, Noha El Kady, Shereen Attalla   +3 more
doaj   +1 more source