Results 21 to 30 of about 59,400 (251)

The ocular albinism type 1 protein, an intracellular G protein-coupled receptor, regulates melanosome transport in pigment cells [PDF]

, 2008
The protein product of the ocular albinism type 1 gene, named OA1, is a pigment cell-specific G protein-coupled receptor exclusively localized to intracellular organelles, namely lysosomes and melanosomes.
Bennett, DC, Venturi C, Palmigiano, A, Schiaffino, MV, Piccirillo, R, Altimare D., Rotondo G., Tacchetti, C, Marigo, V, Bagnato P., Coppola M., Rotondo, G, Venturi, C, Sviderskaya, EV, Palmisano I., Palmigiano A., Altimare D, Bagnato, P, Marigo V., Surace, EM, Altimare, D, Tacchetti C, Innamorati G., Venturi C., Surace E. M., Palmisano I, Rotondo G, INNAMORATI, Giulio, BALLABIO, ANDREA, Schiaffino M. V., Sviderskaya E. V., Palmigiano A, Innamorati G, SURACE, Enrico Maria, Sviderskaya EV, Piccirillo R, Bagnato P, Ballabio A., Incerti B, Piccirillo R., Tacchetti C., Schiaffino MV, Coppola, M, Incerti, B, Bennett DC, Incerti B., Palmisano, I, Coppola M, Bennett D. C., Innamorati, G, Ballabio, A, Marigo V   +51 more
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Technical Note: The Use of RNA-interference as a Tool to Find Proteins Involved in Melanosome Formation or Transport [PDF]

, 2009
Melanosomes are lysosome-related organelles that produce and transport the pigment melanin within melanocytes. Mutations in proteins required for melanosome transport and formation lead to a range of pigmentation defects, manifested at the cellular level
Daniela Rotin, Eva M. Amsen
core   +1 more source

Mechanisms contributing to differential regulation of PAX3 downstream target genes in normal human epidermal melanocytes versus melanoma cells. [PDF]

PLoS ONE, 2015
Melanoma is a highly aggressive and drug resistant form of skin cancer. It arises from melanocytes, the pigment producing cells of the skin. The formation of these melanocytes is driven by the transcription factor PAX3 early during embryonic development.
Danielle Bartlett, Glen M Boyle, Mel Ziman, Sandra Medic   +3 more
doaj   +1 more source

Melanosis of the Uterine Cervix: A Rare Case Report [PDF]

Journal of Clinical and Diagnostic Research, 2021
Cervical melanosis is a rare entity in the spectrum of melanocytic lesions of uterine cervix. Melanosis is defined as presence of melanocytes in the basal layer of squamous epithelium causing hyperpigmentation.
Nikhil Sanjay Deshpande, Aditi Mittal, Anil B Munemane, Ravindra Raosaheb Karle   +3 more
doaj   +1 more source

An in vitro investigation into the pigmentary phenotype of melanocytes and keratinocyte co-cultures to improve wound healing [PDF]

, 2013
Includes abstract.Includes bibliographical references.On healing, partial-thickness burn wounds usually result in depigmentation of the skin. This is due to the loss of melanocytes.
Chang, Ju-Wei
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Convenient methodology for extraction and subsequent selective propagation of mouse melanocytes in culture from adult mouse skin tissue

Biochemistry and Biophysics Reports, 2019
Mouse melanoma B16-BL6 cells are useful cells for cancer metastatic studies. To understand the metastatic principle at molecular levels, it is necessary to carry out experiments in which cancer cells and their normal counterparts are compared.
Nahoko Tomonobu, Rie Kinoshita, I. Wayan Sumardika, Youyi Chen, Yusuke Inoue, Akira Yamauchi, Ken-ichi Yamamoto, Hitoshi Murata, Masakiyo Sakaguchi   +8 more
doaj   +1 more source

Aging of Melanocytes [PDF]

, 1979
Choroidal melanocytes of the eyes of postnatal animals are classified as postmitotic terminally differentiated cells. They have specific granules, the melanosomes, which undergo changes qualitatively and quantitatively correlated to the animal's ...
Hu, Funan
core   +1 more source

Developmental Biology of Mammalian Melanocytes [PDF]

, 1980
The developmental biology of mammalian cutaneous melanocytes spans the entire life cycle from embryo to senescent adult. This review focuses on the inelanocytes of the epidermis.
Fleischmann, Robert D., Quevedo, Walter C.   +1 more
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Number of keratinocytes and melanocytes in cell suspensions obtained from partial-thickness epidermal cuts and suction blister roofs for vitiligo treatment: a prospective randomized comparative study

Journal of the Egyptian Women’s Dermatologic Society, 2020
Background Treatment of vitiligo not responding to conventional therapies involves the replacement of the absent melanocytes by surgical maneuvers, including minigrafting and cultured and noncultured cell suspension grafting.
Tag S Anbar, Tarek S El-Ammawi, Sahar S Mohammed, Amal T Abdel-Rahman   +3 more
doaj   +1 more source

Active Notch1 confers a transformed phenotype to primary human melanocytes [PDF]

, 2009
The importance of mitogen-activated protein kinase signaling in melanoma is underscored by the prevalence of activating mutations in N-Ras and B-Raf, yet clinical development of inhibitors of this pathway has been largely ineffective, suggesting that ...
Liu, Zhao-Jun, Lee, John, Beverly, Levi, Brafford, Patricia, McDaid, Ronan, Zabierowski, Susan, Balint, Klara, Xiao, Min, Himes, Benjamin, Pollock, Pamela, Pinnix, Chelsea   +10 more
core   +1 more source