Results 71 to 80 of about 899,096 (295)

Delivery of Islatravir via High Drug‐Load, Long‐acting Microarray Patches for the Prevention or Treatment of Human Immunodeficiency Virus

Advanced Healthcare Materials, Volume 14, Issue 7, March 14, 2025.
Islatravir‐loaded dissolving microarray patches (MAPs) provide a minimally invasive, long‐acting solution for HIV‐1 prevention and treatment. In rats, sustained islatravir delivery lasts up to three months, while in minipigs, efficacious plasma levels are detected for six days.
Qonita Kurnia Anjani, Ashley R. Johnson, Akmal H. Sabri, Ryan Lutz, Steven Tignor, Jeanine Ballard, Nathan Rudd, Li Zhao, Lalitkumar K. Vora, Stephanie E. Barrett, Angela Wagner, Ryan F. Donnelly   +11 more
wiley   +1 more source

Pathogenicity of 2 Porcine Deltacoronavirus Strains in Gnotobiotic Pigs

Emerging Infectious Diseases, 2015
To verify whether porcine deltacoronavirus infection induces disease, we inoculated gnotobiotic pigs with 2 virus strains (OH-FD22 and OH-FD100) identified by 2 specific reverse transcription PCRs.
K. Jung, Hui Hu, Bryan Eyerly, Zhongyan Lu, Juliet Chepngeno, L. Saif   +5 more
semanticscholar   +1 more source

Towards a novel method for detecting atypical lying down and standing up behaviors in dairy cows using accelerometers and machine learning

Smart Agricultural Technology, 2023
Free-stall cubicles are designed so that cows do not defecate in the bedding material, while still providing comfortable lying places. However, fixed cubicle elements, such as the partition and neck rail, restrict available movement space and may hinder ...
Stijn P. Brouwers, Michael Simmler, Pascal Savary, Madeleine F. Scriba   +3 more
doaj  

Engineering the Future of Restorative Clinical Peripheral Nerve Surgery

Advanced Healthcare Materials, EarlyView.
What if damaged nerves could regenerate more effectively? This review unveils cutting‐edge strategies to restore nerve function, from biomaterial scaffolds and bioactive molecules to living engineered tissues. By accelerating axonal regrowth, preserving Schwann cells, and enhancing connectivity, these approaches are reshaping nerve repair—offering new ...
Justin C. Burrell, Zarina S. Ali, Eric L. Zager, Joseph M. Rosen, Mykhailo M. Tatarchuk, D. Kacy Cullen   +5 more
wiley   +1 more source

One-step generation of knockout pigs by zygote injection of CRISPR/Cas system

Cell Research, 2014
The pig is an important livestock for food supply and an ideal model for various human diseases. Efficient and precise genetic engineering in pigs holds great promise in agriculture and biomedicine1.
T. Hai, Fei Teng, Runfa Guo, Wei Li, Qi Zhou   +4 more
semanticscholar   +1 more source

Co-Infection of Chickens with Staphylococcus lentus and Staphylococcus aureus from an Outbreak of Arthritis, Synovitis, and Osteomyelitis Argues for Detailed Characterisation of Isolates

Animals
Staphylococcus species are widespread in poultry environments and can cause various infections, often when the host’s defences are compromised. This manuscript reports on a co-infection of chickens with Staphylococcus lentus and Staphylococcus aureus ...
Miguel Matos, Peter Mitsch, Dieter Liebhart, Michael Hess, Claudia Hess   +4 more
doaj   +1 more source

Direct Surface Modification of the Epidermis Using Mussel‐Inspired Polydopamine with Multiple Anti‐Biofouling Functions

Advanced Healthcare Materials, EarlyView.
Surface modification using mussel‐derived polydopamine (PDA) is a versatile and robust biocompatible strategy that enables direct application to various epidermal surfaces, regardless of their morphological complexity or surface characteristics. The PDA‐coated epidermis exhibits multiple anti‐biofouling functionalities, including antibacterial and anti‐
Su Eon Lee, Hanna Lee, Jang Hwan Kim, Sungwook Park, Young Taek Oh, Hayoung Choi, Jeong‐Min Kim, Hye‐Jun Jo, Jun Hyun Park, Ho Jun Jin, Kwan Hyi Lee, Seung Ho Han, Hojun Kim, Jun Kyun Oh, Bong Hoon Kim   +14 more
wiley   +1 more source

Targeted mutations in myostatin by zinc-finger nucleases result in double-muscled phenotype in Meishan pigs

Scientific Reports, 2015
Myostatin (MSTN) is a dominant inhibitor of skeletal muscle development and growth. Mutations in MSTN gene can lead to muscle hypertrophy or double-muscled (DM) phenotype in cattle, sheep, dog and human.
L. Qian, M. Tang, Jinzeng Yang, Qingqing Wang, Chunbo Cai, Shengwang Jiang, Hegang Li, Ke Jiang, Pengfei Gao, De-zun Ma, Yaoxing Chen, X. An, Kui Li, W. Cui   +13 more
semanticscholar   +1 more source

Permeation Enhancer‐based Ionogel Shows Remarkable Potential for Oral Insulin Delivery

Advanced Healthcare Materials, EarlyView.
This study proposes a novel formulation of decanoate in an ionic liquid inspired drug delivery system. The formulation demonstrates ideal physicochemical and material properties for oral peptide delivery. Findings indicate that choline decanoate (1:2 molar ratio) forms a viscoelastic gel that enables high oral bioavailability of insulin in rats ...
Konstantinos Raptis, Joanne Heade, Cristiana Cunha, Marco van de Weert, Lasse Saaby, Stine Rønholt, Hanne Mørck Nielsen   +6 more
wiley   +1 more source

Fatty acids, inflammation and intestinal health in pigs

Journal of Animal Science and Biotechnology, 2015
The intestine is not only critical for nutrient digestion and absorption, but also is the largest immune organ in the body. However, in pig production, inflammation induced by numerous factors, such as pathogen infection and stresses (e.g., weaning ...
Yulan Liu
semanticscholar   +1 more source