Results 81 to 90 of about 899,096 (295)

Safety Evaluation of Repeated Application of Polymeric Microarray Patches in Miniature Pigs

Advanced Healthcare Materials, EarlyView.
This study demonstrates the safety of repeated application of three types of microarray patches (MAPs), hydrogelforming, dissolving, and implantable, over four weeks in miniature pigs. No adverse skin or systemic effects were observed, supporting the clinical potential of MAPs as safe and effective drug delivery platforms.
Qonita Kurnia Anjani, Aaron R. J. Hutton, Peter E. McKenna, Eneko Larrañeta, Ryan F. Donnelly   +4 more
wiley   +1 more source

Efficient Generation of Myostatin Mutations in Pigs Using the CRISPR/Cas9 System

Scientific Reports, 2015
Genetically modified pigs are increasingly used for biomedical and agricultural applications. The efficient CRISPR/Cas9 gene editing system holds great promise for the generation of gene-targeting pigs without selection marker genes.
Kankan Wang, Hongsheng Ouyang, Zicong Xie, Chaogang Yao, Nannan Guo, Mengjing Li, H. Jiao, D. Pang   +7 more
semanticscholar   +1 more source

Engineering a Human‐Sized Common Bile Duct Prototype with Regenerative Potential: In Vitro Evaluation of Mechanics, Function, Degradation, and Immune Modulation

Advanced Healthcare Materials, EarlyView.
This study presents a multiphasic bile duct construct composed of biocompatible materials and cells, featuring an inner layer that supports biliary epithelium growth, a middle layer providing mechanical strength, and an outer cell‐permissive layer designed to support future in vivo integration.
Mattia Pasqua, Marianna Barbuto, Matteo Calligaris, Roberto Di Gesù, Duilio Pagano, Rosalia Busà, Salvatore Gruttadauria, Simone Dario Scilabra, Antonio D'Amore, Maria Giovanna Francipane   +9 more
wiley   +1 more source

Integrating Significant SNPs Identified by GWAS for Genomic Prediction of the Number of Ribs and Carcass Length in Suhuai Pigs

Animals
The number of ribs (NRs) and the carcass length (CL) are important economic traits. The traits are usually measured after slaughter. To improve the prediction performance of genomic selection (GS) for NRs and CL, one strategy is to integrate the ...
Kaiyue Liu, Yanzhen Yin, Binbin Wang, Chenxi Liu, Wuduo Zhou, Peipei Niu, Ruihua Huang, Pinghua Li, Qingbo Zhao   +8 more
doaj   +1 more source

3D Bioprinted Renal Constructs Using Kidney‐Specific ECM Bioink System on Kidney Regeneration

Advanced Healthcare Materials, EarlyView.
A kidney‐specific bioink derived from decellularized porcine kidney tissue supports the encapsulation, viability, and maturation of human primary kidney cells within 3D bioprinted constructs. In vivo, it also promotes the recruitment of host renal progenitor cells, collectively enhancing structural and functional regeneration of renal tissue.
Gabriel Carreno‐Caleano, Mohamed Ali, James J. Yoo, Sang Jin Lee, Anthony Atala   +4 more
wiley   +1 more source

Effect of Porcine Epidemic Diarrhea Virus Infectious Doses on Infection Outcomes in Naïve Conventional Neonatal and Weaned Pigs

PLoS ONE, 2015
Porcine epidemic diarrhea virus (PEDV) was identified in the United States (U.S.) swine population for the first time in April 2013 and rapidly spread nationwide.
Joseph T. Thomas, Qi Chen, P. Gauger, L. Gimenez-Lirola, A. Sinha, K. Harmon, D. Madson, E. Burrough, Drew R. Magstadt, H. Salzbrenner, Michael Welch, K. Yoon, J. Zimmerman, Jianqiang Zhang   +13 more
semanticscholar   +1 more source

Cardiac Organoid Model Inspired Micro‐Robot Smart Patch to Treat Myocardial Infarction

Advanced Materials, EarlyView.
The heart organoid model exhibits the acidic microenvironment characteristic of myocardial infarction, which emerges as a pivotal force propelling the movement of micro‐robots. These micro‐robots, administered through microneedles, can penetrate deep into the tissue, effectively delivering therapeutic payloads to facilitate heart repair.
Fangfang Wang, Zilu Xu, Feiyang Zheng, Dongcheng Yang, Kaige Xu, Ming Ke, Xiao Zhou, Xiaohan Zhang, Ju Tan, Yong Liu, Yansha Hao, Malcolm Xing, Chuhong Zhu   +12 more
wiley   +1 more source

Highly efficient CRISPR/Cas9-mediated transgene knockin at the H11 locus in pigs

Scientific Reports, 2015
Transgenic pigs play an important role in producing higher quality food in agriculture and improving human health when used as animal models for various human diseases in biomedicine.
Jinxue Ruan, Hegang Li, Kui Xu, Tianwen Wu, Jingliang Wei, Rong Zhou, Zhiguo Liu, Y. Mu, Shulin Yang, Hongsheng Ouyang, Ruby Yanru Chen-Tsai, Kui Li   +11 more
semanticscholar   +1 more source

Effect of A PLC-Based Drinkers for Fattening Pigs on Reducing Drinking Water Consumption, Wastage and Pollution

Agriculture
In this study, we propose an intelligent drinking water controller based on programmable logic controller (PLC) specifically designed for pig breeding, which significantly reduces the water waste caused by the use of traditional drinking bowls by ...
Jiayao Liu, Hao Wang, Xuemin Pan, Zhou Yu, Mingfeng Tang, Yaqiong Zeng, Renli Qi, Zuohua Liu   +7 more
doaj   +1 more source

From Mechanoelectric Conversion to Tissue Regeneration: Translational Progress in Piezoelectric Materials

Advanced Materials, EarlyView.
This review highlights recent progress in piezoelectric materials for regenerative medicine, emphasizing their ability to convert mechanical stimuli into bioelectric signals that promote tissue repair. Key discussions cover the intrinsic piezoelectric properties of biological tissues, co‐stimulation cellular mechanisms for tissue regeneration, and ...
Xinyu Wang, Sílvio Terra Stefanello, Victor Shahin, Yun Qian   +3 more
wiley   +1 more source