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Localizing Violations of the Principle of Sufficient Reason—Leibniz on the Modal Status of the PSR
Journal of Modern Philosophy, 2022 The Principle of Sufficient Reason (PSR)—the principle that everything has a reason—plays a central role in Leibniz’s philosophical system. It is rather difficult, however, to determine what Leibniz’s attitude towards the modal status of the PSR is.
Sebastian Bender
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Keeping in Touch with PII: PII-Interacting Proteins in Unicellular Cyanobacteria [PDF]
Plant and Cell Physiology, 2007 PII protein is conserved among bacteria, archaea and plants, and is thought to function as a carbon/nitrogen balance sensor in these organisms. Recently, several proteins that specifically interact with PII, including a PII phosphatase (PphA), an amino acid biosynthetic enzyme (NAGK), a probable membrane channel (PamA) and a small protein (PipX) that ...
Takashi, Osanai, Kan, Tanaka
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Malaria Journal, 2020 Background According to the World Health Organization reports, billions of people around the world are at risk for malaria disease and it is important to consider the preventive strategies for protecting the people that are living in high risk areas. One
Javad Dadgar Pakdel +3 more
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Microorganisms, 2022 Recently, antimicrobial activities of various carbon-based nanomaterials against specific pathogens have become one of the most significant research interests in this field.
Naghmeh Hadidi, Maryam Mohebbi
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mSystems, 2020 The PII family comprises a group of widely distributed signal transduction proteins ubiquitous in prokaryotes and in the chloroplasts of plants. PII proteins sense the levels of key metabolites ATP, ADP, and 2-oxoglutarate, which affect the PII protein ...
Edileusa C. M. Gerhardt +16 more
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Autophosphorylation of Yeast Hexokinase PII [PDF]
Microbiology, 1988 Autophosphorylation of hexokinase PII was studied using an enzyme purified from Saccharomyces cerevisiae. Incubation of this enzyme preparation with [gamma-32P]ATP and Mn2+ or Mg2+ gave a phosphoprotein of molecular mass 58,000 which corresponded to hexokinase PII. D-Xylose stimulated autophosphorylation of hexokinase PII.
R, Fernández +5 more
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Scientific Reports, 2021 PII proteins constitute a widespread signal transduction superfamily in the prokaryotic world. The canonical PII signal proteins sense metabolic state of the cells by binding the metabolite molecules ATP, ADP and 2-oxoglutarate.
Rokhsareh Rozbeh, Karl Forchhammer
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From PII signaling to metabolite sensing: a novel 2-oxoglutarate sensor that details PII-NAGK complex formation. [PDF]
PLoS ONE, 2013 The widespread PII signal transduction proteins are known for integrating signals of nitrogen and energy supply and regulating cellular behavior by interacting with a multitude of target proteins.
Jan Lüddecke, Karl Forchhammer
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Structure of the PII signal transduction protein of Neisseria meningitidis at 1.85 Ȃ resolution [PDF]
, 2006 Copyright @ 2006 International Union of CrystallographyThe PII signal transduction proteins GlnB and GlnK are implicated in the regulation of nitrogen assimilation in Escherichia coli and other enteric bacteria.
Berrow, NS +6 more
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Nitrogen regulation of protein–protein interactions and transcript levels of GlnK PII regulator and AmtB ammonium transporter homologs in Archaea [PDF]
, 2013 Gene homologs of GlnK PII regulators and AmtB-type ammonium transporters are often paired on prokaryotic genomes, suggesting these proteins share an ancient functional relationship.
Soppa, Jörg +6 more
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