Results 41 to 50 of about 1,742,283 (219)

Molecular basis for the distinct divalent cation requirement in the uridylylation of the signal transduction proteins GlnJ and GlnB from Rhodospirillum rubrum

BMC Microbiology, 2012
Background PII proteins have a fundamental role in the control of nitrogen metabolism in bacteria, through interactions with different PII targets, controlled by metabolite binding and post-translational modification, uridylylation in most organisms.
Teixeira Pedro, Dominguez-Martin Maria A, Nordlund Stefan   +2 more
doaj   +1 more source

Is There a Correlation Between Pulmonary Inflammation Index With COVID-19 Disease Severity and Outcome?

SVU - International Journal of Medical Sciences, 2022
Background: The radiologic pulmonary inflammatory index (PII) may be used as an early predictor of inflammation as laboratory assessments in COVID-19 cases.
Islam Galal *, Aliae AR Mohamed Hussein, Mohammed M. Mohammed, Howaida K. Abd ElAal, Karim Aly, Islam ElNakeeb, Ahmed Hamdy Ahmed Mhsb, Mohamed M. Amin   +7 more
doaj   +1 more source

Rainbow: reliable personally identifiable information retrieval across multi-cloud

Cybersecurity, 2023
Personally identifiable information (PII) refers to any information that links to an individual. Sharing PII is extremely useful in public affairs yet hard to implement due to the worries about privacy violations.
Zishuai Song, Hui Ma, Shuzhou Sun, Yansen Xin, Rui Zhang   +4 more
doaj   +1 more source

Artificial Intelligence‐Driven Extraction of Patient‐Reported Pain Outcomes in Osteoarthritis Using Large Language Models

Arthritis Care &Research, Accepted Article.
Objective Patient‐reported outcome measures (PROMs) are central to assessing symptom burden and treatment response in Osteoarthritis (OA) but are often embedded in unstructured clinical notes. We evaluated whether prompt‐engineered large language models (LLMs) could accurately extract or infer pain scores on a 0‐10 scale from routine OA clinical ...
Jainesh Doshi, Stephen Batter, Yiyuan Wu, William Salerno, Alice Santilli, Sandhya Kannayiram, Susan Goodman, Bella Mehta   +7 more
wiley   +1 more source

Escherichia coli Glutamine Synthetase Adenylyltransferase (ATase, EC 2.7.7.49):  Kinetic Characterization of Regulation by PII, PII-UMP, Glutamine, and α-Ketoglutarate^†

, 2016
Glutamine synthetase adenylyltranferase (ATase, EC 2.7.7.49) catalyzes the adenylylation and deadenylylation of glutamine synthetase (GS), regulating GS activity.
Avraham E. Mayo (384895), Peng Jiang (16544), Alexander J. Ninfa (1265832)   +2 more
core   +2 more sources

A State‐Gated Metallo‐DNAzyme Framework Programs Tumor Stress Vulnerability Through Metabolic Licensing

Advanced Science, EarlyView.
A tumor‐state‐gated metallo‐DNAzyme framework integrates miR‐21/APE1‐responsive GLUT1 silencing with Ca/Cu‐partitioned metal–nucleic acid assembly and cystine loading. The framework first weakens glucose‐dependent metabolic buffering and then amplifies copper‐ and disulfide‐associated stress, converting tumor metabolic adaptation into programmable ...
Xiaodong Ma, Lingyun He, Xinru Wang, Yuanyuan Wei, Chengcheng Li, Jiaqi Yan, Weijian Sun, Xian Shen, Hongbo Zhang   +8 more
wiley   +1 more source

Inhibition of carboxypeptidase b1 from Anopheles stephensi by the potato carboxypeptidase inhibitor: a foundational step toward paratransgenesis-based malaria control

Malaria Journal
Vector-borne diseases such as malaria are a threat to global public health and the economy. These diseases were proposed to be managed and controlled by new preventive strategies such as paratransgenesis. This is an innovative technique that makes use of
Zahra Monshizadeh, Elham Rismani, Fatemeh Abdi, Javad Dadgar pakdel, Negin Ghanbarnejad, Abbasali Raz   +5 more
doaj   +1 more source

Structural and Functional Characteristics of Two Molecular Variants of the Nitrogen Sensor PII in Maritime Pine

Frontiers in Plant Science, 2020
High levels of nitrogen are stored as arginine during the last stages of seed formation in maritime pine (Pinus pinaster Aiton). The protein sensor PII regulates the feedback inhibition of arginine biosynthesis through interaction with the key enzyme N ...
María Teresa Llebrés, María Belén Pascual, Carolina Valle, Fernando N. de la Torre, José Miguel Valderrama-Martin, Luis Gómez, Concepción Avila, Francisco M. Cánovas   +7 more
doaj   +1 more source

Asymmetric Structure‐Driven Functional Synergy: A Multistimuli‐Activated Janus Nanomotor for Self‐Amplifying NO Cascade Therapy

Advanced Science, EarlyView.
The Janus nanomotors leverage an “asymmetric structure‐driven functional synergy” strategy to orchestrate spatiotemporally coordinated catalytic functions, in situ self‐amplifying NO generation, and deep tumor penetration, thereby enabling controllable, sustained, and uniform NO generation within the tumor microenvironment.
Chengcheng Li, Yu Zhang, Yu Chen, Lingyun He, Xian Shen, Weijian Sun, Hongbo Zhang   +6 more
wiley   +1 more source

Casi-ortogonalidad y proximidad en L2 de martingalas pii en casi intervalos

Revista de Matemática: Teoría y Aplicaciones, 2009
It was introduced in [2] the notion of prOcess with independent increments in near-intervals (PII), establishing the existence of a decomposition into components with certain regularity properties.
Jaime Lobo Segura
doaj   +1 more source