Targeting Supramolecular Active Complexes of Nav1.7/Nav1.8 to Relieve Chronic Neuropathic Pain
Advanced Science, Volume 13, Issue 41, 22 July 2026.In mice and patients with severe chronic neuropathic pain (NP), Nav1.7, Nav1.8, TrkB, and five cytoskeletal proteins form supramolecular active complexes (SMACs) with polygonal lattice structures as noxious signal amplifiers in dorsal root ganglion (DRG) neurons.
Liting Sun +27 more
wiley +1 more source
Interactions between the PII protein and its receptors revealed by NanoBiT technology
The PII proteins are notable members of a vast and ancient protein family involved in signal transduction. These molecules are found in all living organisms and are primarily recognized for their ability to sense metabolites such as ATP, ADP, and 2 ...
Rozbeh, Rokhsareh
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PLoS ONE, 2010 BackgroundGranulosa cell tumors (GCT) of the ovary often express aromatase and synthesize estrogen, which in turn may influence their progression. Recently a specific point mutation (C134W) in the FOXL2 protein was identified in >94% of adult-type GCT ...
Nicholas I Fleming +5 more
doaj +1 more source
Genetic transformation of genes for protein II in Neisseria gonorrhoeae. [PDF]
, 1986 The protein II (PII) outer membrane proteins of Neisseria gonorrhoeae are a family of heat-modifiable proteins that are subject to phase variation, in which the synthesis of different PII species is turned on and off at a high frequency.
Schwalbe, R S, Cannon, J G
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PII T-loop mutations affecting signal transduction to NtrB also abolish yeast two-hybrid interactions [PDF]
, 2002 Mutations A49P and [Delta]47-53 at the T loop of the Escherichia coli GlnB (PII) protein impair regulatory interactions with the two-component sensor regulator NtrB (P. Jiang, P. Zucker, M. R. Atkinson, E. S. Kamberov, W. Tirasophon, P. Chandran, B.
Martínez Argudo, Isabel +1 more
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, 2011 PII signal transduction proteins have key functions in coordination of central metabolism by integrating signals from carbon, nitrogen and energy status of the cell.
Fokina, Oleksandra
core
PII is induced by WRINKLED1 and fine-tunes fatty acid composition in seeds of Arabidopsis thaliana
, 2010 P>The PII protein is an integrator of central metabolism and energy levels. In Arabidopsis, allosteric sensing of cellular energy and carbon levels alters the ability of PII to interact with target enzymes such as N-acetyl-l-glutamate kinase and ...
Michael Hodges +21 more
core +1 more source
Crystal structures of adenylylated and unadenylylated P<sub>II</sub> protein GlnK from Corynebacterium glutamicum. [PDF]
Acta Crystallogr D Struct Biol, 2021 Grau FC, Burkovski A, Muller YA.
europepmc +1 more source
Escherichia coli methionine-tRNAi/methionyl tRNA synthetase pairs induced protein initiation of interest (PII) expression [PDF]
, 2022 Jung Min Kim +2 more
openalex +1 more source
Keeping in touch with PII: PII-interacting proteins in unicellular cyanobacteria
Keeping in touch with PII: PII-interacting proteins in unicellular cyanobacteriaidentifier:oai:t2r2.star.titech.ac.jp ...
openaire +3 more sources