Results 101 to 110 of about 20,835 (311)

THE SHEAR BEHAVIOUR OF THE REINFORCED CONCRETE FOUR-PILE CAPS [PDF]

open access: yes, 2009
There has been a consistent discrepancy between UK design standards BS5400 and BS8110 in the prediction of the shear capacity of 2-way spanning reinforced concrete pile caps from bending theory-based empirical design formulae.
Cao, Jing
core  

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

open access: yesMolecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq   +8 more
wiley   +1 more source

Raman‐based label‐free microscopic analysis of the pancreas in living zebrafish larvae

open access: yesFEBS Open Bio, EarlyView.
Forward stimulated Raman scattering (F‐SRS) and epi coherent anti‐Stokes Raman scattering (E‐CARS) allow label‐free discrimination of distinct subcellular structures in the pancreas of living zebrafish larvae. Given the straightforward applicability, we anticipate broad implementation of Raman microscopy in other organs and across various biomedical ...
Noura Faraj   +3 more
wiley   +1 more source

Dynamic Response Difference of Single Pile and Pile Group with Variable Section in Variation of Seismic Subsidence Soil Layer

open access: yesShanghai Jiaotong Daxue xuebao
In order to study the difference of dynamic response between large diameter variable section single pile and pile group foundations in seismic subsidence soil with different thicknesses under ground motion, based on the Xiang’an Bridge of Xiamen Second ...
FENG Zhongju, WANG Wei, ZHANG Cong, ZHU Jixin, WANG Yiran, MENG Yingying
doaj   +1 more source

Numerical modelling of rows of discrete piles used to stabilise landslides under long-term conditions in clays [PDF]

open access: yes, 2013
A literature review found no rigorous solution for the ultimate lateral pile-soil pressure ( ) in a soil characterised by a frictional failure criterion, and that the popular empirical methods to estimate give profiles with depth that differ ...
Pan, D.
core  

Polarization‐resolved femtosecond Vis/IR spectroscopy tailored for resolving weak signals in biological samples using minimal sample volume

open access: yesFEBS Open Bio, EarlyView.
Unique biological samples, such as site‐specific mutant proteins, are available only in limited quantities. Here, we present a polarization‐resolved transient infrared spectroscopy setup with referencing to improve signal‐to‐noise tailored towards tracing small signals. We provide an overview of characterizing the excitation conditions for polarization‐
Clark Zahn, Karsten Heyne
wiley   +1 more source

A light‐triggered Time‐Resolved X‐ray Solution Scattering (TR‐XSS) workflow with application to protein conformational dynamics

open access: yesFEBS Open Bio, EarlyView.
Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei   +3 more
wiley   +1 more source

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

open access: yesFEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane   +11 more
wiley   +1 more source

A Swastik Pile Foundation: Application of a Roto-reciprocation Mechanism in Pile Foundation

open access: yesJournal of Mines, Metals and Fuels
Discovering the optimum pile foundation design in terms of economy and performance is imperative because pile foundations are crucial to geotechnical engineering, as they support high-significance structures like bridges, high-rise buildings, power plant stations, offshore platforms, and museums.
Yuvaraj Bhirud   +4 more
openaire   +1 more source

Wave-induced Pore Pressure Responses and Soil Liquefaction Around Pile Foundation [PDF]

open access: yes, 2011
A 3D FEM model is proposed and verified with existing experimental data for simulating wave-induced transient and residual pore pressure responses around a pile foundation.
杨兵   +4 more
core  

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