Results 91 to 100 of about 208,931 (305)

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source

Bearing Capacity of Pile Foundations Embedded in Clays and Sands Layer Predicted Using PDA Test and Static Load Test [PDF]

, 2015
Static Load Test (SLT) is the realiable method to determine bearing capacity of pile foundations. However, SLT is relatively expensive and time consuming compared to Pile Driving Analyzer (PDA) test.
Budi, Gogot Setyo, KOSASI, MELISA, WIJAYA, DEWI HINDRA   +2 more
core   +1 more source

Analysis of the effect and influencing factors of CFG pile composite foundation treatment in west Sichuan high-plateau airport

Journal of Asian Architecture and Building Engineering
In this study, the finite element model (FEM) of the CFG pile composite foundation underlayered filling of the high-fill embankments was established by numerical simulation to analyze the treatment effect and influencing factors of CFG pile composite ...
Yanjun Liu, Jun Feng, Xiaomei Lu, Peilin Zou, Zikang Chen, Jizhe He, Zhuoya Zhao, Jian Wu   +7 more
doaj   +1 more source

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

Dynamic Response Difference of Single Pile and Pile Group with Variable Section in Variation of Seismic Subsidence Soil Layer

Shanghai Jiaotong Daxue xuebao
In order to study the difference of dynamic response between large diameter variable section single pile and pile group foundations in seismic subsidence soil with different thicknesses under ground motion, based on the Xiang’an Bridge of Xiamen Second ...
FENG Zhongju, WANG Wei, ZHANG Cong, ZHU Jixin, WANG Yiran, MENG Yingying
doaj   +1 more source

Differential expression of cancer‐related genes supports prediction of poor response to first‐line treatments in T‐ALL pediatric patients with high minimal residual disease

Molecular Oncology, EarlyView.
In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera, Laura Vela‐Martín, Pablo Fernández‐Navarro, José Luis López‐Lorenzo, Javier Cornago, Pilar Llamas, Eduardo Pérez‐Gómez, José Luis Marín‐Rubio, Manuel Fresno, Javier Santos, José Fernández‐Piqueras, María Villa‐Morales   +11 more
wiley   +1 more source

Pengaruh Beban Vertikal terhadap Daya Dukung Lateral Pondasi Tiang [PDF]

, 2016
Pile foundations are intended to hold both vertical and horizontal loads. Pile foundation design must take into account the lateral carrying capacity, especially on those that experience large lateral force.
', M. (Muhardi), Nugroho, S. A. (Soewignjo), Suryadi, R. '. (Rudy)   +2 more
core  

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

Analisa Perhitungan Pile – Raft Foundation Pada Proyek the 18 Office Park Jakarta [PDF]

, 2014
Sebuah struktur bangunan bertingkat tinggi harus memiliki sebuah pondasi yang kokoh yang mampu menopang seluruh beban struktur bangunan tersebut. Oleh karena itu, haruslah dipilih jenis pondasi yang tepat yang mampu menyalurkan beban bangunan ke lapisan ...
trenggana, S. A. (siti)
core  

Insights into a long life without cancer: The case of the bowhead whale

Molecular Oncology, EarlyView.
Long‐lived, large‐bodied organisms have evolved powerful anticancer mechanisms that preserve cellular and tissue integrity across extended lifespans. A recent study by Firsanov et al. shows that greater genome stability is a key factor underlying the remarkable longevity and cancer resistance of one such species, the bowhead whale.
Inés Paniagua, Johanna A. Joyce
wiley   +1 more source