Results 71 to 80 of about 12,054 (263)

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Dynamic Response Difference of Single Pile and Pile Group with Variable Section in Variation of Seismic Subsidence Soil Layer

Shanghai Jiaotong Daxue xuebao
In order to study the difference of dynamic response between large diameter variable section single pile and pile group foundations in seismic subsidence soil with different thicknesses under ground motion, based on the Xiang’an Bridge of Xiamen Second ...
FENG Zhongju, WANG Wei, ZHANG Cong, ZHU Jixin, WANG Yiran, MENG Yingying
doaj   +1 more source

An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes

FEBS Letters, EarlyView.
GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg, Martine Hjeltnes, Josephine Krieger, Joshua E. Elias, Maria Stensland, Kristian Holm, Xiaojun Jiang, Chuki Khangsar, Tuula A. Nyman, Arthur Kaser, Johannes R. Hov, Tom H. Karlsen, Nicole C. Kaneider, Frode L. Jahnsen, Georg Schneditz   +14 more
wiley   +1 more source

Influence of Pile Foundation Construction on Existing Tunnels in a Metro Protection Area: Field Test and Numerical Simulation

Buildings
On the basis of the Fengqi Chaoming project in Hangzhou City, Zhejiang Province, China, this paper investigates the influence of pile foundation construction on the existing tunnels in a metro protection area to ensure the stability and safety of the ...
Gang Lin, Wenbin Ke, Shuaishuai Guo, Zhaorui Lin, Changjie Xu, Minliang Chi, Yue Xiao   +6 more
doaj   +1 more source

Simplified Method for Consolidation Settlement Calculation of Combined Composite Foundation

Shock and Vibration, 2020
Treating weak saturated soil foundation by drainage powder jetting pile foundation can not only increase the bearing capacity of the foundation but also accelerate the drainage and consolidation process of the foundation.
Fei Liu, Kang Qin, Yongsheng Han
doaj   +1 more source

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics

FEBS Letters, EarlyView.
Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt, Ana‐Maria Sandru, Georg Vucak, Sebastian Didusch, Biljana Riemelmoser, Karin Ehrenreiter, Markus Hartl, Lukas A. Huber, Manuela Baccarini   +8 more
wiley   +1 more source

Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network

FEBS Letters, EarlyView.
Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley   +1 more source

A Swastik Pile Foundation: Application of a Roto-reciprocation Mechanism in Pile Foundation

Journal of Mines, Metals and Fuels
Discovering the optimum pile foundation design in terms of economy and performance is imperative because pile foundations are crucial to geotechnical engineering, as they support high-significance structures like bridges, high-rise buildings, power plant stations, offshore platforms, and museums.
Yuvaraj Bhirud, Khemraj Shinde, Satish More, Ayub Shaikh, Kamalkishor Maniyar   +4 more
openaire   +1 more source

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source