Results 51 to 60 of about 12,235 (260)

pH‐mediated activation of the lysosomal arginine sensor SLC38A9

FEBS Letters, EarlyView.
Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley   +1 more source

Effect of the failure mode on the macro-response of pile groups

, 2022
This paper contributes to the generalisation of existing models that describe the multiaxial response of pile groups. Most of these models, including a specific model proposed by the Authors, assume that the foundation piles are rigidly connected to the raft.
Gorini, Davide Noè: Callisto, Luigi
openaire   +2 more sources

Septin 9 PB domains coordinate centrosome positioning and microtubule acetylation to control epithelial polarity

FEBS Letters, EarlyView.
Septin 9 polybasic domains couple phosphoinositide‐rich membrane binding to centrosome positioning, Golgi organization, and microtubule acetylation to control epithelial polarity. Their loss disrupts this axis, causing centrosome mispositioning, Golgi fragmentation, reduced microtubule acetylation, and polarity inversion via upregulation of the ...
Ting ting Cai, Mohyeddine Omrane, Nassima Benzoubir, Didier Samuel, Ama Gassama‐Diagne   +4 more
wiley   +1 more source

Model Test Study on the Vertical Uplift Bearing Characteristics of Soil Continuous Solidified Pile Group Foundations

Buildings
To solve the problem of the high bearing capacity of structures in deep and weak soil layers, we invented a new type of pile group foundation in which the soil was continuously solidified between piles (hereinafter referred to as the SCS pile group ...
Tao Sun, Fakai Yang, Xinzhuang Cui, Zhaochao Huang, Xianzhou Lyu, Ruijin Ma, Yujun Chang, Shengmei Liu, Chen Wang, Zhiyuan Lin, Xiaoning Zhang   +10 more
doaj   +1 more source

An unexpected alternative viologen electron mediator site in tungsten‐containing formate dehydrogenase

FEBS Letters, EarlyView.
An unexpected alternative interaction site for ethyl viologen was identified in formate dehydrogenase 1 from Methylorubrum extorquens. Combined mutagenesis, kinetic analysis, and docking revealed that aromatic residues near an iron–sulfur cluster enable flavin mononucleotide‐independent electron transfer, offering a framework for engineering improved ...
Eleni G. Poloniataki, Yong Hwan Kim
wiley   +1 more source

Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis

FEBS Letters, EarlyView.
Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee, Junho Jeong, Chae Yeong Lee, Hyunjoon Cho, Man Hwan Oh, Je Chul Lee, Jee‐Young Lee, Yangmee Kim   +7 more
wiley   +1 more source

Stability Analysis of Accumulative Formation Slope Reinforced by Inclined Micropile Group

Renmin Zhujiang, 2020
Based on the finite difference software FLAC3D and strength reduction method, this paperanalyzes the law between the inclination angle of pile and the supporting effect of accumulativeformation slope reinforced by the inclined micropile group.
WANG Xiaozhe, LIU Linlin
doaj  

Behavior of pile group incorporating dissimilar pile embedded into sand

Alexandria Engineering Journal, 2015
Piles are recommended to transfer the superstructure loads safely through soil by friction resistance and end bearing into firm bearing stratum. Piles drive their load via weak soil into competent bearing stratum.
F.M. Abdrabbo, A.Z. El-wakil
doaj   +1 more source

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

Field Test and Numerical Simulation of Squeezing Effect of Large-Diameter Pipe Piles

Advances in Civil Engineering
In order to study the squeezing effect of static press large-diameter single pile and piles group in layered soil, field tests of static press large-diameter pipe piles were carried out based on a project under construction, and numerical simulations of ...
Yongqiang An, Shaolong Guo, Manman Liang, Qun Lu   +3 more
doaj   +1 more source