Results 81 to 90 of about 17,411,117 (298)
Numerical simulation of the impact of pile groups of high-pile wharves on hydrodynamic parameters
Shuili Shuiyun Gongcheng XuebaoPile foundation wharves are commonly used dock structures with widespread applications. The foundations of high-pile wharves, consisting of groups of piles, alter the surrounding hydrodynamic field, causing changes in the sedimentation and erosion ...
XUE Yurao +4 more
doaj +1 more source
Molecular Oncology, EarlyView.In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera +11 more
wiley +1 more source
Effect of Pile Spacing on Load Bearing Performance of NT-CEP Pile Group Foundation
BuildingsThe NT-CEP pile is an innovative type of pile that builds upon the conventional concrete straight-hole cast-in-place pile. It primarily consists of two components: the main pile and the bearing plate. The key factors influencing its load-bearing capacity
Yongmei Qian +6 more
doaj +1 more source
Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization
Molecular Oncology, EarlyView.In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu +13 more
wiley +1 more source
Journal of Rock Mechanics and Geotechnical EngineeringPile group-supported bridges in liquefied sloping ground with crust are prone to severe damage. However, there remains a limited comprehension of the intricate interactions among pile group, soil, and superstructures, as well as the associated failure ...
Kemin Jia +4 more
doaj +1 more source
Molecular Oncology, EarlyView.The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington +10 more
wiley +1 more source
THE SHEAR BEHAVIOUR OF THE REINFORCED CONCRETE FOUR-PILE CAPS
, 2009 There has been a consistent discrepancy between UK design standards BS5400 and BS8110 in the prediction of the shear capacity of 2-way spanning reinforced concrete pile caps from bending theory-based empirical design formulae.
Cao, Jing
core +1 more source
Machine induced dynamic field responses of group pile with different pile arrangements
International Journal of Geo-EngineeringThe main objective of the current investigation is to study the dynamic behaviour of a 3-pile group with different loading direction under coupled (horizontal and rocking) excitations.
Sumit Kumar +2 more
doaj +1 more source
Shuiwen dizhi gongcheng dizhiTo improve the load-bearing of transmission tower micropile foundation and reduce the material cost, a modified variable diameter micropile foundation type based on group micropile is proposed in this study.
Guangming REN +5 more
doaj +1 more source
Molecular Oncology, EarlyView.Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq +8 more
wiley +1 more source