Results 111 to 120 of about 235,431 (305)

Determination method for horizontal load-bearing capacity of pile group for large LNG tank

You-qi chuyun
Objective The pile group foundation for large LNG tanks is subjected to relatively large horizontal forces under two seismic conditions: Operating Basis Earthquake (OBE) signifying a 10% probability of exceedance within a 50-year period and Safe Shutdown
Chengguo WEI, Hanwen WANG, Wentao LIU, Wei CUI, Wangyu ZHAN   +4 more
doaj   +1 more source

The deposition of bronzes at Swiss lakeshore settlements: new investigations [PDF]

, 2017
The famous lakeside sites of Switzerland have long been known for their pile dwellings and their massive quantities of Late Bronze Age metalwork. On the most recent excavations, the bronzes have been mapped in situ, allowing comparison with assemblages ...
Fischer, Viktoria
core  

Molecular dynamics simulations of positively selected codons in FcγRI reveal novel biochemical binding properties

FEBS Open Bio, EarlyView.
Evolutionary analysis across 32 placental mammals identified positive selection at residues H148 and W149 in the immune receptor FcγR1. Ancestral reconstruction combined with molecular dynamics simulations reveals how these mutations may influence receptor structure and dynamics, providing insight into the evolution of antibody recognition and immune ...
David A. Young, Omar Arias‐Gaguancela, Fiona Gibson, Morgan Grainger, Jodie Score, Amit Nathubhai, Mauricio Cafiero, Lee Richard Machado   +7 more
wiley   +1 more source

A Comparative Evaluation of Approximate Probabilistic Simulation and Deep Neural Networks as Accounts of Human Physical Scene Understanding [PDF]

, 2016
Humans demonstrate remarkable abilities to predict physical events in complex scenes. Two classes of models for physical scene understanding have recently been proposed: "Intuitive Physics Engines", or IPEs, which posit that people make predictions by ...
Freeman, William T., Tenenbaum, Joshua B., Wu, Jiajun, Zhang, Chengkai, Zhang, Renqiao   +4 more
core   +1 more source

Experimental Demonstration of Multiple Monoenergetic Gamma Radiography for Effective Atomic Number Identification in Cargo Inspection

, 2018
The smuggling of special nuclear materials (SNM) through international borders could enable nuclear terrorism and constitutes a significant threat to global security.
Danagoulian, Areg, Henderson, Brian S., Lee, Hin Y., MacDonald, Thomas D., Nelson, Roberts G.   +4 more
core   +1 more source

RoundMi: A quantitative method to analyze mitochondrial morphology in mitotic cells

FEBS Open Bio, EarlyView.
RoundMi is a workflow for rapid analysis of mitochondrial morphology in mitotic cells. By combining adaptive preprocessing with automated segmentation and quantification, it enables accurate measurements from single focal plane images, reducing acquisition time and computational demands while remaining compatible with high‐throughput fixed and live ...
Elmira Parvindokht Bararpour, Christine Volmert, Valentina Piano   +2 more
wiley   +1 more source

Mutant NPM1 in Acute Myeloid Leukemia Initiation and Maintenance

Aging and Cancer, EarlyView.
NPM1 mutations drive acute myeloid leukemia by acting as neomorphic transcriptional regulators that cooperate with Menin–MLL and XPO1 to sustain HOX/MEIS1 expression and block differentiation. Targeting these mutant‐specific transcriptional dependencies provides a rational therapeutic strategy for NPM1‐mutated AML.
Yanan Jiang, Zhong Fan, Runmeng Liu, Xiaotian Zhang   +3 more
wiley   +1 more source

Long‐Term Follow‐Up of Chemotherapy‐Associated Biological Aging in Women With Early Breast Cancer

Aging and Cancer, EarlyView.
Women threated with adjuvant chemotherapy for early breast cancer have sustained long‐term increase in p16INK4a,, a robust marker of cell senescence, suggesting a chemotherapy‐associated age acceleration. p16INK4a as well as other biomarkers may identify patients at greatest risk for senescence‐related diseases of aging.
Hyman B. Muss, Alexis C. Wardell, Allison M. Deal, Kirsten A. Nyrop, Allison Ross, Yara G. Abdou, Jeffrey D. Aldrich, Lisa A. Cary, E. Claire Dees, Katherine E. Reeder‐Hayes, Emily M. Ray, Natalia Mitin, Denis Tsygankov   +12 more
wiley   +1 more source

Remote Monitoring in Myasthenia Gravis: Exploring Symptom Variability

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Myasthenia gravis (MG) is a rare, autoimmune disorder characterized by fluctuating muscle weakness and potential life‐threatening crises. While continuous specialized care is essential, access barriers often delay timely interventions. To address this, we developed MyaLink, a telemedical platform for MG patients.
Maike Stein, Maximilian Mönch, Meret Herdick, Frauke Stascheit, Sarah Hoffmann, Hannah Preßler, Philipp Mergenthaler, Carla Dusemund, Paolo Doksani, Haoqi Sun, Pushpa Narayanaswami, Andreas Meisel, Lea Gerischer, Sophie Lehnerer   +13 more
wiley   +1 more source

Local scour around varied-configuration pile groups in silty seabed under steady current: An experimental study

Applied Ocean Research
This experimental study investigates the effects of pile arrangement patterns on local scour characteristics around pile groups in silty seabed.
Shengtao Du, Chaolin Wang, Ming Gong, Fangfang Zhu, Guoxiang Wu, Bingchen Liang   +5 more
doaj   +1 more source