Results 91 to 100 of about 5,494,204 (259)

Artificial Neural Network Model for Predicting Local Equilibrium Scour Depth at Pile Groups in Steady Currents

Journal of Marine Science and Engineering
Piles are common support elements for marine and coastal structures. The scour around pile foundations caused by currents is a major threat to the stability and safety of these structures.
Xinao Zhao, Ping Dong, Yan Li, Yan Zhou, Xiaoying Zhao, Qing Wang, Chao Zhan   +6 more
doaj   +1 more source

Extracellular vesicle lipidomics liquid biopsy reveals systemic and tumor microenvironment metabolic reprogramming in ovarian cancer

Molecular Oncology, EarlyView.
Extracellular vesicle (EV) lipidomic profiling of plasma and ascites from patients with high‐grade serous ovarian cancer and of ovarian cancer cell lines reveals enrichment of triglycerides (TGs), diacylglycerols (DGs), phosphatidylcholine (PCs), sphingomyelins (SMs), reflecting tumor metabolic reprogramming.
Shikha Rani, Dominic Guanzon, Andrew Lai, Katherin Scholz‐Romero, Sarah Reed, Edita Ritmejeryte, Rohan Lourie, Naven Chetty, Kaltin Ferguson, Carlos Salomon   +9 more
wiley   +1 more source

Experimental study on lateral pile-soil pressure on passive part of pile groups in innovative sheet-pile wharf

Yantu gongcheng xuebao, 2018
The pile group of vertical cast-in-place piles with relief platform has been successfully introduced into innovative sheet-pile wharfs to withhold lateral load due to horizontal soil movement along with its front wall.
XU Guang-ming 1,2, REN Guo-feng 1,2, GU Xing-wen 1,2, CHEN Ai-zhong 3, LI Le-chen 4
doaj   +1 more source

Paclitaxel induces NM2‐dependent cellular contraction through GEF‐H1 dissociation from microtubules and RhoA/ROCK activation in cancer cells

Molecular Oncology, EarlyView.
Taxanes are widely used chemotherapeutics whose effects on cellular mechanics remain poorly understood. We show that paclitaxel induces rapid cellular contraction by promoting GEF‐H1 dissociation from microtubules and non‐muscle myosin II activation through RhoA/ROCK.
Gloria Asensio‐Juárez, Rafael Pérez‐Díaz, Hugo Ramos‐Solano, Marina Garrido‐Casado, Vanessa C. Talayero, Miguel Vicente‐Manzanares   +5 more
wiley   +1 more source

SPHINX31 acts as a SRPK1 inhibitor targeting the ATR/DNA‐PKcs/CHK1 replicative checkpoint to inhibit cell growth in non‐small cell lung cancer

Molecular Oncology, EarlyView.
The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim, Aurelie Genoux, Nadiia Zubchuk, Haoyang Zheng, Perla Salameh, Theo Ziegelmeyer, Fabien Dalonneau, Margot Rouchette, Christiane Oddou, Simona Miron, Helene Polveche, Adiilah Mamode Cassim, Carmen Garrido, Eleni Nikolakaki, Didier Auboeuf, Tao Jia, Sophie Zinn‐Justin, Beatrice Eymin   +17 more
wiley   +1 more source

Shear capacity of reinforced concrete pile caps

Reinforced concrete pile caps may be considered to act either as deep beams, or analogous to a truss. When designed as a deep beam, there is currently a contradiction in the shear design between two UK structural engineering codes of practice – the ...
Cao, J., Xu, M., Bloodworth, A.G.
core   +1 more source

Manly [cartographic material] : 7 villa sites near tram line, ocean views 12/6 per foot /

, 1890
Sales plan for land in the suburb of Queenscliff in Sydney bounded by Pittwater Road, Queenscliff Road and Pavillion Street.; "Torrens title."; Also available in an electronic version via the internet at: http://nla.gov.au/nla.map ...
Pile, G.
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Mutant p53R273H disrupts PDPK1 homodimerization and contributes to PDPK1 activation

Molecular Oncology, EarlyView.
How mutant p53R273H drives AKT signaling is unclear. We show that p53R273H, but not wild‐type, directly binds PDPK1 via a mutation‐dependent conformational change. This interaction disrupts inhibitory PDPK1 homodimerization and enhances AKT phosphorylation.
Mei Chee Lim, Alvin Kunyao Guo, Yoko Itahana, Srinivasaraghavan Kannan, Valerie Goh, Mingmin Ong, Terina Yan Wen Tay, Weiying Ye, Sabhashina Radha Krishnan, Jun Nishiyama, Chandra S Verma, Koji Itahana   +11 more
wiley   +1 more source

Experimental Study of Negative Skin Friction of Pile Group Foundations for Offshore Wind Turbines on Artificial Islands

Journal of Marine Science and Engineering
Constructing offshore wind turbines on artificial islands is considered a viable option, but negative skin friction (NSF) is a significant adverse factor that cannot be ignored.
Yeyu Yan, Guoliang Dai, Zhiwei Chen, Tao Hu, Weiming Gong, Chenchen Shi   +5 more
doaj   +1 more source

Fairview Estate, Manly [cartographic material] : for sale on the ground /

, 1885
Sales plan for land in the suburb of Manly in Sydney bounded by The Corso, Esplanade, The Crescent, Fairlight Street and George Street.; "Terms, 10% deposit, balance in 12 quarterly payments, interest 5%."; Also available in an electronic version via the
Mills & Pile.
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