Results 81 to 90 of about 5,494,204 (259)
Molecular Oncology, EarlyView.In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera +11 more
wiley +1 more source
Lateral capacity and deformations of vertical piles loaded by horizontal forces [PDF]
Građevinski Materijali i Konstrukcije, 2018 Pile foundations are frequently loaded by horizontal forces. In such cases, it is important to calculate lateral capacity of vertical piles. It is governed by the strength of the surrounding soil i.e. geotechnical capacity or pile strength parameters i.e.
Ćorić Slobodan +3 more
doaj
Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization
Molecular Oncology, EarlyView.In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu +13 more
wiley +1 more source
Molecular Oncology, EarlyView.The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington +10 more
wiley +1 more source
THE SHEAR BEHAVIOUR OF THE REINFORCED CONCRETE FOUR-PILE CAPS
, 2009 There has been a consistent discrepancy between UK design standards BS5400 and BS8110 in the prediction of the shear capacity of 2-way spanning reinforced concrete pile caps from bending theory-based empirical design formulae.
Cao, Jing
core +1 more source
A Continuum-Based Model for Analysis of Laterally Loaded Piles in Layered Soils [PDF]
, 2009 An analysis is developed to calculate the response of laterally loaded piles in multilayered elastic media. The displacement fields in the analysis are taken to be the products of independent functions that vary in the vertical, radial and ...
Salgado, Rodrigo +2 more
core +1 more source
, 1978 An investigation of local scour at pile groups has been conducted with the aim of developing design recommendations. A series of steady uniform flow experiments was carried out with the scour hole characteristics recorded.
Hannah, Chris
core +1 more source
Molecular Oncology, EarlyView.Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq +8 more
wiley +1 more source
Laboratory Study of Local Scour Around an Array of Pile Groups in Clear-Water Scour Conditions
Journal of Marine Science and EngineeringCurrent-induced local scour around pile groups weakens the capacity of structures. In this paper, experimental tests of local scour around an array of 5 × 5 pile groups were conducted in a steady current in a hydraulic flume.
Ming Gong +7 more
doaj +1 more source
Molecular Oncology, EarlyView.This study integrates publicly available transcriptomic datasets to identify molecular signatures associated with response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer. By analyzing a combination of multiple cohorts with bioinformatics approaches, we reveal biological pathways and immune‐related features that may improve ...
Aleksandra Stanojevic +10 more
wiley +1 more source