Results 61 to 70 of about 5,494,204 (259)
Development of LRFD Procedures for Bridge Pile Foundations in Iowa, September 2011 [PDF]
, 2011 In response to the mandate on Load and Resistance Factor Design (LRFD) implementations by the Federal Highway Administration (FHWA) on all new bridge projects initiated after October 1, 2007, the Iowa Highway Research Board (IHRB) sponsored these ...
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Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential
FEBS Letters, EarlyView.Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta +3 more
wiley +1 more source
An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes
FEBS Letters, EarlyView.GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg +14 more
wiley +1 more source
Yantu gongcheng xuebaoAn analytical model for the "pile-soil-pile" horizontal interaction in pile groups that accounts for the scattering effect of the receiver pile is presented in this study based on the plane strain model, to modify the calculating theory for closely ...
ZHENG Changjie1, 2 , CUI Yiqin1, 2, DING Xuanming3, LUAN Lubao4
doaj +1 more source
Simplified analysis of laterally loaded pile groups
Alexandria Engineering Journal, 2012 The response of laterally loaded pile groups is a complicated soil–structure interaction problem. Although fairly reliable methods are developed to predicate the lateral behavior of single piles, the lateral response of pile groups has attracted less ...
F.M. Abdrabbo, K.E. Gaaver
doaj +1 more source
Structure‐forward targeting of claudins with synthetic binders
FEBS Letters, EarlyView.Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley +1 more source
Numerical simulation of the impact of pile groups of high-pile wharves on hydrodynamic parameters
Shuili Shuiyun Gongcheng XuebaoPile foundation wharves are commonly used dock structures with widespread applications. The foundations of high-pile wharves, consisting of groups of piles, alter the surrounding hydrodynamic field, causing changes in the sedimentation and erosion ...
XUE Yurao +4 more
doaj +1 more source
Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics
FEBS Letters, EarlyView.Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt +8 more
wiley +1 more source
Static pile-soil-pile interaction in offshore pile groups [PDF]
, 1994 This thesis is a theoretical study, using both finite element and boundary element methods, of the behaviour of single-piles and pile groups under vertical and lateral loading.
Burd, H. J. +2 more
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MODELLING OF PILED RAFT FOUNDATIONS IN SAND [PDF]
, 2010 A piled raft is a composite foundation in which the piles are used as settlement reducers and they share, with the raft, the load from the superstructure.
Giretti, Daniela
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