Results 41 to 50 of about 92,611 (307)

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Experimental study on the mechanical behaviour of a heat exchanger pile using physical modelling [PDF]

, 2014
International audienceThis study aims to provide knowledge on the thermo-mechanical behaviour of heat exchanger piles, through a laboratory scale model. The model pile (20 mm in external diameter) was embedded in dry sand.
Hassen, Ghazi, Pereira, Jean-Michel, Tang, Anh Minh,, Yavari, Neda   +3 more
core   +4 more sources

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

An Empirical Study for Estimating Ultimate Bearing Capacity of Concrete Small-Pile Cluster in Soft Clays

Journal of Applied Engineering and Technological Science
Soft subgrades with shear strength, cu of 10 kPa to 25 kPa are given low bearing capacity and high settlement. Local government has been built infrastructure of embankment such unpaved road on the soft subgrade by using timber and bamboo materials ...
Suyuti Suyuti, Mukhlis Muslimin
doaj   +1 more source

Korelasi Penentuan Daya Dukung Tiang Cara Empirik (Cpt) Dengan Pile Driven Analysis (Pda) Di Kota Pekanbaru [PDF]

, 2007
Axial bearing capacity of pile foundation can be estimated empirically from cone penetration test (CPT). Actual capacity of foundation can be obtained from static load test or pile driving analyzer (PDA).
Nugroho, S. (SA), Yusa, M. (Muhamad)
core  

CHD pile performance, Part I:Physical modelling [PDF]

, 2016
The Continuous Helical Displacement (CHD) pile is an auger displacement pile developed by Roger Bullivant Ltd in the UK. It has performance characteristics of both displacement and non-displacement piles due to the nature in which it is installed.
Bell A, Berezantzev VG, Brown MJ, Busch P, Bustamante M, Fleming WGF, GCG (Geotechnical Consulting Group), Jamiolkowski M, Jeffrey JR, John Ross Jeffrey, Jonathan Adam Knappett, Jonathan David Ball, Karlis Caucis, Katzenbach R, Kenny MJ, Lauder K, Meyerhof GG, Michael John Brown, Mindess S, Mitsch MP, Randolph MF, Thorburn S, Ueno K, van Impe WF, Wade S, Young HD   +25 more
core   +2 more sources

pH‐mediated activation of the lysosomal arginine sensor SLC38A9

FEBS Letters, EarlyView.
Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley   +1 more source

Influencing factors of deep excavation on bearing capacity and settlement of piles beneath excavation

Yantu gongcheng xuebao, 2017
The deep excavation has a significant influence on the bearing capacity and settlement of piles beneath excavation. However, there are few researches on the influencing factors, especially the distribution of strata.
DIAO Yu 1, 2, LI Guang-shuai 1, 2, ZHENG Gang 1, 2
doaj   +1 more source

COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells

Molecular Oncology, EarlyView.
This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos, Gilar Gorji‐bahri, Lejla Gradjan, Julia Zajac, Kacper Gil, Yvonne Thokozile Nduku, Anna M. Blom   +6 more
wiley   +1 more source

Management of Pile End Sediment and Its Influence on the Bearing Characteristics of Bored Pile

Buildings
In order to study the influence of pile end sediment on the bearing characteristics of bored piles, the on-site bearing capacity test was conducted on a single pile.
Weibin Song, Zhengzhen Wang, Wentao Zhu, Junping Yang, Jianming Zeng   +4 more
doaj   +1 more source