Results 81 to 90 of about 479,217 (327)

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

Effect of Passive Pile on 3D Ground Deformation and on Active Pile Response

The Scientific World Journal, 2014
Using a series of model tests, this study investigated the effect of a passive pile on 3D ground deformation around a laterally loaded pile and on that laterally loaded pile’s response in sand. The active pile head was subjected to lateral loads, and the
Bingxiang Yuan, Rui Chen, Jun Teng, Tao Peng, Zhongwen Feng   +4 more
doaj   +1 more source

Co-located wave and offshore wind farms: A preliminary approach to the shadow effect [PDF]

, 2014
In recent years, with the consolidation of offshore wind technology and the progress carried out for wave energy technology, the option of combine both technologies has arisen.
Abanades, J, Astariz, S, Greaves, D, iglesias, G, Perez Collazo, C   +4 more
core   +1 more source

Enzymatic degradation of biopolymers in amorphous and molten states: mechanisms and applications

FEBS Open Bio, EarlyView.
This review explains how polymer morphology and thermal state shape enzymatic degradation pathways, comparing amorphous and molten biopolymer structures. By integrating structure–reactivity principles with insights from thermodynamics and enzyme engineering, it highlights mechanisms that enable efficient polymer breakdown.
Anđela Pustak, Aleksandra Maršavelski
wiley   +1 more source

Model tests on 3D soil arching in pile-supported embankments with and without geotextile

Case Studies in Construction Materials
Compared to traditional soil improvement methods such as preloading, vertical drains, or grouting injection, et al., pile-supported reinforced embankments are increasing widely employed in the construction of highways on soft soils.
Weiping Cao, Zedong Xie, Yaxin Yue, Min Zhao, Qing Li, Weiwei Hu   +5 more
doaj   +1 more source

Polarization‐resolved femtosecond Vis/IR spectroscopy tailored for resolving weak signals in biological samples using minimal sample volume

FEBS Open Bio, EarlyView.
Unique biological samples, such as site‐specific mutant proteins, are available only in limited quantities. Here, we present a polarization‐resolved transient infrared spectroscopy setup with referencing to improve signal‐to‐noise tailored towards tracing small signals. We provide an overview of characterizing the excitation conditions for polarization‐
Clark Zahn, Karsten Heyne
wiley   +1 more source

The Design of Piles under Combined Loading: Effect of Pile Length, Pile Spacing and Relative Density

Journal of Innovations in Civil Engineering and Technology
In pile foundation systems, displacements in important structures affected by both axial and lateral loads must be limited within elastic limits. For elastic limits; effects of the important parameters such as; pile diameter, pile spacing, pile length /pile diameter ratio and relative density were examined.
Münire Fındık, İlyas Devran Çelik, Ercan Egemen Başar, Nilay Keskin, Soner Uzundurukan   +4 more
openaire   +1 more source

Orientation-dependent indentation response of helium-implanted tungsten

, 2019
A literature review of studies investigating the topography of nano-indents in ion-implanted materials reveals seemingly inconsistent observations, with report of both pile-up and sink-in.
Das, Suchandrima, Hofmann, Felix, Tarleton, Edmund, Yu, Hongbing   +3 more
core   +1 more source

Multi‐omics and low‐input proteomics profiling reveals dynamic regulation driving pluripotency initiation in early mouse embryos

FEBS Open Bio, EarlyView.
Mouse pre‐implantation development involves a transition from totipotency to pluripotency. Integrating transcriptomics, epigenetic profiling, low‐input proteomics and functional assays, we show that eight‐cell embryos retain residual totipotency features, whereas cytoskeletal remodeling regulated by the ubiquitin‐proteasome system drives progression ...
Wanqiong Li, Xi Xiao, Lingbin Qi, Chanyi Li, Sirui Song, Jiaying Qin, Zhigang Xue, Jinfeng Xue, Huaifang Li   +8 more
wiley   +1 more source

Vertical bearing capacity of a pile-liquefiable sandy soil foundation under horizontal seismic force.

PLoS ONE, 2020
In this study, research on a pile group system was conducted using shaking table tests under four working conditions: a natural foundation and pile-spacing conditions of 3D, 3.5D, and 4D (D is the diameter of the pile).
Huang Zhanfang, Bai Xiaohong, Yin Chao, Wang Yanping   +3 more
doaj   +1 more source