Results 61 to 70 of about 43,676 (287)
Molecular Oncology, EarlyView.Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau +36 more
wiley +1 more source
Stability Limits of Circumbinary Planets: Is There a Pile-up in the Kepler CBPs?
, 2018 The stability limit for circumbinary planets (CBPs) is not well defined and can depend on initial parameters defining either the planetary orbit or the inner binary orbit. We expand on the work of Holman & Wiegert (1999, AJ 117, 621) to develop numerical
Haghighipour, Nader +4 more
core +1 more source
Molecular Oncology, EarlyView.Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova +14 more
wiley +1 more source
Molecular Oncology, EarlyView.In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera +11 more
wiley +1 more source
Shuiwen dizhi gongcheng dizhiThe double-row pile system without a connecting beam is challenging to implement in practical engineering because of its complex load characteristics and the lack of a standardized model for soil pressure between piles.
Ke TANG +3 more
doaj +1 more source
Molecular Oncology, EarlyView.We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu +10 more
wiley +1 more source
Evaluation of compressive capacity of helical pile resting in cohesionless soil [PDF]
International Journal of Mining and Geo-EngineeringCurrent research deals with the numerical investigation on the behavior of helical piles resting in cohesionless soil subjected to compressive load.
Jitendra Yadav +2 more
doaj +1 more source
Studia Geotechnica et Mechanica, 2020 In a piled-raft foundation, the interaction between structural elements and soil continuum can be simulated very precisely by numerical modeling. In the present study, 3D finite element model has been used to examine the settlement, load-sharing, bending
Mali Shivanand, Singh Baleshwar
doaj +1 more source
CO-LOCATED WAVE AND OFFSHORE WIND FARMS: A PRELIMINARY CASE STUDY OF AN HYBRID ARRAY [PDF]
, 2014 In recent years, with the consolidation of offshore wind technology and the progress carried out for wave energy technology, the option of co-locate both technologies at the same marine area has arisen.
Abanades, J +4 more
core +3 more sources
The Design of Piles under Combined Loading: Effect of Pile Length, Pile Spacing and Relative Density
Journal of Innovations in Civil Engineering and TechnologyIn pile foundation systems, displacements in important structures affected by both axial and lateral loads must be limited within elastic limits. For elastic limits; effects of the important parameters such as; pile diameter, pile spacing, pile length /pile diameter ratio and relative density were examined.
Münire Fındık +4 more
openaire +1 more source