Results 51 to 60 of about 2,681 (255)

Patient therapy outcome modeling in cancer organoids is improved by cancer‐associated fibroblasts and organoid assembly convolution

Molecular Oncology, EarlyView.
Patient‐derived organoids (PDOs) from pancreatic, colorectal, and gastric cancers were used to evaluate standard and experimental therapies. Incorporating cancer‐associated fibroblasts (CAFs) into organoid cultures improved patient therapy outcome prediction.
Marcin Grochowski, Liudmyla Dolinchuk, Michał Jerzak, Albert Gandurski, Tomasz Grochowski, Weronika Wojtyś, Maciej Zadrożny, Wojciech Kaźmierczak, Małgorzata Lenarcik, Marta Matejak‐Górska, Radosław Samsel, Tomasz Olesiński, Dawid Walerych   +12 more
wiley   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Determination of the optimal row distance for double row piles and the calculation method for earth pressure between piles

Shuiwen dizhi gongcheng dizhi
The double-row pile system without a connecting beam is challenging to implement in practical engineering because of its complex load characteristics and the lack of a standardized model for soil pressure between piles.
Ke TANG, Hua ZHAO, Xuefeng TANG, Rusong CHENG   +3 more
doaj   +1 more source

Polarization‐resolved femtosecond Vis/IR spectroscopy tailored for resolving weak signals in biological samples using minimal sample volume

FEBS Open Bio, EarlyView.
Unique biological samples, such as site‐specific mutant proteins, are available only in limited quantities. Here, we present a polarization‐resolved transient infrared spectroscopy setup with referencing to improve signal‐to‐noise tailored towards tracing small signals. We provide an overview of characterizing the excitation conditions for polarization‐
Clark Zahn, Karsten Heyne
wiley   +1 more source

Compressive Behavior of Micropile According to Pile Spacing and Embedded Pile Angle in Sand

Journal of the Korean Geotechnical Society, 2013
Micropile technology has evolved continuously since its instruction by Fernando Lizzi in the 1950s. The effects of group micropile have been researched by many researchers. The effects of group micropile differ and change with pile length, pile spacing (S), pile angle () and pile embedded conditions.
Doo-Hyun Kyung, Ga-Ram Kim, Dae-Hong Kim, Ju-Ho Shin, Jun-Hwan Lee   +4 more
openaire   +2 more sources

A light‐triggered Time‐Resolved X‐ray Solution Scattering (TR‐XSS) workflow with application to protein conformational dynamics

FEBS Open Bio, EarlyView.
Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei, Fredrik Orädd, Konstantinos Magkakis, Magnus Andersson   +3 more
wiley   +1 more source

BEHAVIOR OF MODEL GROUP PILES SUBJECTED TO LATERAL SOIL MOVEMENT IN SAND

Journal of Engineering and Sustainable Development, 2017
Laboratory model tests have been carried out to explore the behavior of piles subjected to lateral soil movement in sand. The results of a single pile test and ten tests on of group piles arranged in a row (perpendicular to the direction of soil ...
Saad Farhan Ibraheem, Mohammed Khachi Hatem   +1 more
doaj  

Thermal Performance of an Energy Pile Group with a Deeply Penetrating U-Shaped Heat Exchanger

Energies, 2020
This study presents a novel heat exchanger configuration, called a deeply penetrating U-shaped configuration, for energy piles. The outlet water temperature, temperature variation along the tube, and heat transfer rate are simulated and computed using ...
Weidong Lyu, Hefu Pu, Jiannan (Nick) Chen   +2 more
doaj   +1 more source

Evolutionarily divergent DUF4465 domains have a common vitamin B12‐binding function

FEBS Open Bio, EarlyView.
We show that DUF4465 family proteins, widespread across bacteria from gut microbiomes, hydrothermal vents, and soil, share a common vitamin B12‐binding function. These augmented β‐jellyroll proteins bind vitamin B12 via extended loops. Our findings establish sequence‐diverse DUF4465 proteins as a widespread class of B12‐binding proteins, highlighting ...
Charlea Clarke, Michal Banasik, Rokas Juodeikis, Martin J. Warren, Richard W. Pickersgill   +4 more
wiley   +1 more source

3D Numerical Modeling of Large Piled-Raft Foundation on Clayey Soils for Different Loadings and Pile-Raft Configurations

Studia Geotechnica et Mechanica, 2020
In a piled-raft foundation, the interaction between structural elements and soil continuum can be simulated very precisely by numerical modeling. In the present study, 3D finite element model has been used to examine the settlement, load-sharing, bending
Mali Shivanand, Singh Baleshwar
doaj   +1 more source