Results 51 to 60 of about 260,800 (246)
Molecular Oncology, EarlyView.Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq +8 more
wiley +1 more source
Scour Development in Square Pile Groups: Effects of Pile Number and Spacing
Civil Engineering DimensionLocal scour around pile group foundations poses a significant risk to hydraulic and coastal structures, particularly when multiple piles interact with complex flow patterns. This study presents a numerical investigation of local scour around pile groups
Aisyah Dwi Puspasari, Jyh-Haw Tang
doaj +1 more source
Mutant p53R273H disrupts PDPK1 homodimerization and contributes to PDPK1 activation
Molecular Oncology, EarlyView.How mutant p53R273H drives AKT signaling is unclear. We show that p53R273H, but not wild‐type, directly binds PDPK1 via a mutation‐dependent conformational change. This interaction disrupts inhibitory PDPK1 homodimerization and enhances AKT phosphorylation.
Mei Chee Lim +11 more
wiley +1 more source
THE SHEAR BEHAVIOUR OF THE REINFORCED CONCRETE FOUR-PILE CAPS
, 2009 There has been a consistent discrepancy between UK design standards BS5400 and BS8110 in the prediction of the shear capacity of 2-way spanning reinforced concrete pile caps from bending theory-based empirical design formulae.
Cao, Jing
core +1 more source
RoundMi: A quantitative method to analyze mitochondrial morphology in mitotic cells
FEBS Open Bio, EarlyView.RoundMi is a workflow for rapid analysis of mitochondrial morphology in mitotic cells. By combining adaptive preprocessing with automated segmentation and quantification, it enables accurate measurements from single focal plane images, reducing acquisition time and computational demands while remaining compatible with high‐throughput fixed and live ...
Elmira Parvindokht Bararpour +2 more
wiley +1 more source
Development of LRFD Procedures for Bridge Pile Foundations in Iowa Final Report, June 2010 [PDF]
, 2010 For well over 100 years, the Working Stress Design (WSD) approach has been the traditional basis for geotechnical design with regard to settlements or failure conditions.
core
BEHAVIOR OF MODEL GROUP PILES SUBJECTED TO LATERAL SOIL MOVEMENT IN SAND
Journal of Engineering and Sustainable Development, 2017 Laboratory model tests have been carried out to explore the behavior of piles subjected to lateral soil movement in sand. The results of a single pile test and ten tests on of group piles arranged in a row (perpendicular to the direction of soil ...
Saad Farhan Ibraheem +1 more
doaj
Shuiwen dizhi gongcheng dizhiThe double-row pile system without a connecting beam is challenging to implement in practical engineering because of its complex load characteristics and the lack of a standardized model for soil pressure between piles.
Ke TANG +3 more
doaj +1 more source
Pathways and pitfalls: a qualitative study of student experiences in biomedical science education
FEBS Open Bio, EarlyView.Biomedical science students from underrepresented backgrounds face barriers including financial strain, disrupted laboratory access and cultural exclusion. Peer networks provide vital support when institutional systems are difficult to navigate. To create inclusive learning environments and achieve academic success, educators should blend active, hands‐
Olivia J. Russell +8 more
wiley +1 more source
FEBS Open Bio, EarlyView.Miniaturized flow chip platform enabling continuous perfusion and longitudinal multiphoton 3D imaging of vascular smooth muscle cell constructs under physiological flow. Brightfield imaging guides region selection, while CellTracker Green and mRuby‐labeled fetuin‐A visualize cells and mineral deposition, respectively. Magnesium supplementation markedly
Vytautas Kučikas +6 more
wiley +1 more source