Results 31 to 40 of about 260,800 (246)
FEBS Letters, EarlyView.Septin 9 polybasic domains couple phosphoinositide‐rich membrane binding to centrosome positioning, Golgi organization, and microtubule acetylation to control epithelial polarity. Their loss disrupts this axis, causing centrosome mispositioning, Golgi fragmentation, reduced microtubule acetylation, and polarity inversion via upregulation of the ...
Ting ting Cai +4 more
wiley +1 more source
The behaviour of laterally loaded two-pile groups [PDF]
, 1992 The response of piles and two-pile groups to lateral loading has been studied by field tests and computationally. Due to the lack of field test data and because of uncertainty concerning the pile/soil system it has been suggested that further ...
Arta, M.R., Arta, Mahmood Reza
core
Design and analysis strategies for robust microbiome ageing research
FEBS Letters, EarlyView.The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik +5 more
wiley +1 more source
Analysis of a rapid load test on an instrumented bored pile in clay [PDF]
, 2006 Rapid load testing methods for piled foundations are generally easier and quicker to mobilise than classic static tests, and are less complex to analyse than dynamic load tests.
Brown, M. J.; id_orcid +2 more
core +1 more source
Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential
FEBS Letters, EarlyView.Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta +3 more
wiley +1 more source
Science ProgressThis study aims to investigate the impact of isolation piles on soil vibrations in the environment surrounding suburban railways. Initially, a comprehensive numerical model of the train was established to simulate the wheel-rail interaction forces, which
Shusen Cao +9 more
doaj +1 more source
Structure‐forward targeting of claudins with synthetic binders
FEBS Letters, EarlyView.Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley +1 more source
Advances in Civil Engineering, 2022 The bearing capacity of the rock-socketed part of the end-suspended pile and rock-socketed pile was investigated. Numerical models have been partially established with half of the pile and half of the pile space to simplify the model and reduce the ...
Xiaobo Xing +5 more
doaj +1 more source
Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics
FEBS Letters, EarlyView.Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt +8 more
wiley +1 more source
Scientific ReportsA pile group under lateral loading is a complex pile‒soil-pile interaction problem. In this study, numerical analysis was used to investigate the lateral behavior of pile groups arranged in a 3 × 3 configuration with varying piles spacings.
Jiandong Li +3 more
doaj +1 more source