Results 31 to 40 of about 2,681 (255)

Septin 9 PB domains coordinate centrosome positioning and microtubule acetylation to control epithelial polarity

FEBS Letters, EarlyView.
Septin 9 polybasic domains couple phosphoinositide‐rich membrane binding to centrosome positioning, Golgi organization, and microtubule acetylation to control epithelial polarity. Their loss disrupts this axis, causing centrosome mispositioning, Golgi fragmentation, reduced microtubule acetylation, and polarity inversion via upregulation of the ...
Ting ting Cai, Mohyeddine Omrane, Nassima Benzoubir, Didier Samuel, Ama Gassama‐Diagne   +4 more
wiley   +1 more source

Numerical Analysis of the End-Suspended Pile and the Rock-Socketed Pile Bearing Capacity of a Soil-Rock Composite Foundation Pit

Advances in Civil Engineering, 2022
The bearing capacity of the rock-socketed part of the end-suspended pile and rock-socketed pile was investigated. Numerical models have been partially established with half of the pile and half of the pile space to simplify the model and reduce the ...
Xiaobo Xing, Xiangyang Li, Wei Li, Tu Lu, Xiaofeng Duan, Qing Jin   +5 more
doaj   +1 more source

An unexpected alternative viologen electron mediator site in tungsten‐containing formate dehydrogenase

FEBS Letters, EarlyView.
An unexpected alternative interaction site for ethyl viologen was identified in formate dehydrogenase 1 from Methylorubrum extorquens. Combined mutagenesis, kinetic analysis, and docking revealed that aromatic residues near an iron–sulfur cluster enable flavin mononucleotide‐independent electron transfer, offering a framework for engineering improved ...
Eleni G. Poloniataki, Yong Hwan Kim
wiley   +1 more source

Effect of periodic vibration-isolation piles on soil vibration in deep-buried tunnels of suburban railways

Science Progress
This study aims to investigate the impact of isolation piles on soil vibrations in the environment surrounding suburban railways. Initially, a comprehensive numerical model of the train was established to simulate the wheel-rail interaction forces, which
Shusen Cao, Dong Li, Jili Yin, Qin Xu, Dongdong Qian, Chao Chen, Hongkai Wang, Lunzheng Zhang, Xiangdong Shi, Futong Wang   +9 more
doaj   +1 more source

Influence of Spacing and Cross-Sectional Shaft of Screw Piles Group on Lateral Capacity

Diyala Journal of Engineering Sciences, 2021
Although there are several high-capacity screw piles in use currently, there are few studies on their lateral performance. The aim of this study is to investigate the lateral behaviour of several models of screw pile group (1×2), (2×1), and (2×2 ...
Azhar Subhi, Hassan O. Abbas
doaj   +1 more source

Modelling the dynamic pile-soil-pile interaction in a multi-layered half-space [PDF]

, 2015
Within the context of railway ground-borne vibration, the dynamic pile-soil-pile interaction remains an area that has not been sufficiently investigated. Whilst a number of researchers have scrutinised the vibration response of piled-foundations, their approaches exhibit a compromise between computation time and solution accuracy.
Hamad, Waleed, Ntotsios, Evangelos, Hunt, Hugh, Hussein, M.F.M., Thompson, D.J., Talbot, James   +5 more
openaire   +2 more sources

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

The Design of Piles under Combined Loading: Effect of Pile Length, Pile Spacing and Relative Density

Journal of Innovations in Civil Engineering and Technology
In pile foundation systems, displacements in important structures affected by both axial and lateral loads must be limited within elastic limits. For elastic limits; effects of the important parameters such as; pile diameter, pile spacing, pile length /pile diameter ratio and relative density were examined.
Münire Fındık, İlyas Devran Çelik, Ercan Egemen Başar, Nilay Keskin, Soner Uzundurukan   +4 more
openaire   +1 more source

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

Molecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau, Leonor Garcia, Hugo Arnold, Antonija Hanžek, Maialen Arrieta, Laurent R Gauthier, Christine Granotier‐Beckers, François D Boussin, Amaury Herbet, Marie Hautière, Valentin Asei‐Ceschino, Clémentin Jacques, Laura Brard, Thomas Harnois, Valérie Coronas, Bruno Constantin, Aurélien Chatelier, Jean Chemin, Serge Urbach, Martial Seveno, Szimonetta Hideg, Chantal Ripoll, Kasandra Aguilar‐Cázarez, Min Zheng, Guo‐Hao Huang, Sheng‐Qing Lv, Lei Zhang, Philippe Rondard, Laurent Prezeau, Jean‐Philippe Pin, Hugues Duffau, Luc Bauchet, Valérie Rigau, Franck Denat, Charles Truillet, Didier Boquet, Jean‐Philippe Hugnot   +36 more
wiley   +1 more source

Numerical study on the lateral behavior of pile groups in Toyoura sand using the hypoplastic constitutive model

Scientific Reports
A pile group under lateral loading is a complex pile‒soil-pile interaction problem. In this study, numerical analysis was used to investigate the lateral behavior of pile groups arranged in a 3 × 3 configuration with varying piles spacings.
Jiandong Li, Yuting Zhang, Guangzong Yuan, Tianqi Bian   +3 more
doaj   +1 more source