Results 101 to 110 of about 80,000 (303)
Development of LRFD Procedures for Bridge Pile Foundations in Iowa: Volume II: Field Testing of Steel Piles in Clay, Sand, and Mixed Soils and Data Analysis, September 2011 [PDF]
, 2011 In response to the mandate on Load and Resistance Factor Design (LRFD) implementations by the Federal Highway Administration (FHWA) on all new bridge projects initiated after October 1, 2007, the Iowa Highway Research Board (IHRB) sponsored these ...
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Molecular Oncology, EarlyView.The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington +10 more
wiley +1 more source
Influence of relative stiffness on the behavior of piled raft foundations
Acta Scientiarum: Technology, 2018 The behavior of piled foundations is influenced by several factors, especially those related to the geometry of the foundations, the number of piles, the height of the element that tops the piles and the type of soil in which the foundations are inserted.
Jean Rodrigo Garcia +1 more
doaj +1 more source
Molecular Oncology, EarlyView.Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq +8 more
wiley +1 more source
An analytical approach to pile-to-pile interaction for end-bearing piles
GéotechniqueThis study introduces an analytical approach to treat pile-to-pile interaction for axially loaded, end-bearing piles. Building upon an available Tajimi-type soil model and an application of Graf’s addition theorem, the proposed solution simultaneously considers both the source and the receiver piles.
Della Corte, A. +4 more
openaire +3 more sources
Molecular Oncology, EarlyView.This study integrates publicly available transcriptomic datasets to identify molecular signatures associated with response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer. By analyzing a combination of multiple cohorts with bioinformatics approaches, we reveal biological pathways and immune‐related features that may improve ...
Aleksandra Stanojevic +10 more
wiley +1 more source
The thermal performance of foundation piles used as heat exchangers in ground energy systems
, 2012 Pile heat exchangers are expected to make a significant contribution to meeting UK and EU renewable energy and carbon dioxide reduction targets. However, design for the thermal capacity of pile heat exchangers has to date been largely based on methods ...
Loveridge, F.
core +1 more source
Design and Performance Verifcation of Ultra-High Performance Concrete Piles for Deep Foundations Final Report, November 2008 [PDF]
, 2008 The strategic plan for bridge engineering issued by AASHTO in 2005 identified extending the service life and optimizing structural systems of bridges in the United States as two grand challenges in bridge engineering, with the objective of producing ...
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Molecular Oncology, EarlyView.Extracellular vesicle (EV) lipidomic profiling of plasma and ascites from patients with high‐grade serous ovarian cancer and of ovarian cancer cell lines reveals enrichment of triglycerides (TGs), diacylglycerols (DGs), phosphatidylcholine (PCs), sphingomyelins (SMs), reflecting tumor metabolic reprogramming.
Shikha Rani +9 more
wiley +1 more source
Prevalence and risk factors of hemorrhoids in Jazan Region, Saudi Arabia: A cross-sectional study
Journal of Family Medicine and Primary CareBackground: Hemorrhoids a prevalent anorectal disorder, have gained rising attention due to their impact on public health and quality of life. Despite their significance, limited research has addressed their prevalence and associated risk factors in the ...
Hassan Mashbari +11 more
doaj +1 more source