Results 121 to 130 of about 350,542 (323)

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source

RIPK4 function interferes with melanoma cell adhesion and metastasis

Molecular Oncology, EarlyView.
RIPK4 promotes melanoma growth and spread. RIPK4 levels increase as skin lesions progress to melanoma. CRISPR/Cas9‐mediated deletion of RIPK4 causes melanoma cells to form less compact spheroids, reduces their migratory and invasive abilities and limits tumour growth and dissemination in mouse models.
Norbert Wronski, Sławomir Lasota, Ewelina Madej, Anna A. Brożyna, Małgorzata Szczygieł, Agnieszka Harazin‐Lechowska, Jan Czerbniak, Janusz Rys, Jaroslaw Czyz, Agnieszka Wolnicka‐Glubisz   +9 more
wiley   +1 more source

Numerical Modelling of Factors Critical to Slope Stability with Plaxis 2D

Mehran University Research Journal of Engineering and Technology
Slope instability is among the primary issues in geotechnical engineering that can result in loss of life and property. This study assessed slope stability by Factor of Safety (FOS) in FEM Plaxis 2D software with different geotechnical and hydrological ...
Muhammad Rehan Hakro, Imtiaz Ali Hakro, Rabia Soomro, Faisal Ahmed Rajper, Shehnaz Hakro   +4 more
doaj   +1 more source

Blocking Wythoff Nim

, 2010
The 2-player impartial game of Wythoff Nim is played on two piles of tokens. A move consists in removing any number of tokens from precisely one of the piles or the same number of tokens from both piles.
Larsson, Urban
core   +1 more source

Rethinking plastic waste: innovations in enzymatic breakdown of oil‐based polyesters and bioplastics

FEBS Open Bio, EarlyView.
Plastic pollution remains a critical environmental challenge, and current mechanical and chemical recycling methods are insufficient to achieve a fully circular economy. This review highlights recent breakthroughs in the enzymatic depolymerization of both oil‐derived polyesters and bioplastics, including high‐throughput protein engineering, de novo ...
Elena Rosini, Nicolò Antonelli, Gianluca Molla   +2 more
wiley   +1 more source

Numerical Investigation of the Effect of Geocell-Reinforced Cushion on Load Distribution and Settlement Reduction in Unconnected Piled Raft Foundations

Firat University Journal of Experimental and Computational Engineering
The effect of geocell-reinforced cushion on load distribution and settlement reduction in unconnected piled raft foundations was investigated. Modeling and analysis of various scenarios were carried out using Abaqus software. In this research, a total of
Mojtaba Pourgholamali, Farzin Asgharpour
doaj   +1 more source

Homologous expression and purification of human HAX‐1 for structural studies

FEBS Open Bio, EarlyView.
This research protocol provides detailed instructions for cloning, expressing, and purifying large quantities of the intrinsically disordered human HAX‐1 protein, N‐terminally fused to a cleavable superfolder GFP, from mammalian cells. HAX‐1 is predicted to undergo posttranslational modifications and to interact with membranes, various cellular ...
Mariana Grieben
wiley   +1 more source

Diabetes‐induced vascular calcification is associated with low pyrophosphate and its oral supplementation prevents calcification in diabetic mice

FEBS Open Bio, EarlyView.
Induction of diabetes in three different mouse strains uniformly resulted in an increase in TNAP activity and a reduction in pyrophosphate (PPi) in the circulation. Inhibition of TNAP restored plasma PPi. Diabetes‐induced calcification in the media layer of the aorta was detected only in the Abcc6−/− strain, which is predisposed to ectopic ...
Krisztina Fülöp, Eszter Kozák, Natália Tőkési, Lilian Kocsis, Anikó Kelemen, Zsuzsanna Geszti, Adriána Kutás, Mariann Harangi, Ágnes Diószegi, Zsolt Rapi, József Balla, Olivier Le Saux, András Váradi, Viola Pomozi   +13 more
wiley   +1 more source

Model test on the load bearing mechanism of inclined pile-sheet retaining wall

矿业科学学报
The inclined pile-sheet retaining wall differs from the traditional pile-sheet retaining wall in the stress and distribution of earth pressure behind the wall because of the inclination of the retaining plates. Its mechanism is unclear while its existing
GE Sha, WANG Weijun, QU Hongxia, WANG Meng, ZHANG Min   +4 more
doaj   +1 more source

Assessing the applicability of thermal response testing to energy piles

, 2014
Deep foundations are increasingly being used, not just to carry structural loads, but also to act as heat exchangers as part of a ground source heat pump system.
Brettmann, T., Loveridge, F.A., Olgun, C.G., Powrie, W.   +3 more
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