Results 71 to 80 of about 80,000 (303)

Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis

FEBS Letters, EarlyView.
Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee, Junho Jeong, Chae Yeong Lee, Hyunjoon Cho, Man Hwan Oh, Je Chul Lee, Jee‐Young Lee, Yangmee Kim   +7 more
wiley   +1 more source

Wave forces on cylindrical piles and pile groups : a critical review [PDF]

, 1990
Includes bibliography.This thesis is a critical review of methods of predicting wave forces on vertical piles or groups of piles. It assigns different force prediction theories to different situations or flow regimes and analyses their advantages and ...
Shaul, Robert
core   +1 more source

Geomechanical Substantiation of the Technology of Constructing Modular Pile Foundations of Technological Platforms in Permafrost Rocks

Geotechnics
Existing pile foundations in the Arctic face significant limitations regarding bearing capacity, environmental impact, and dismantling capabilities.
Vladimir Leonidovich Trushko, Vladimir Yakovlevich Klimov, Elena Konstantinovna Baeva, Anatoly Yurievich Ozhigin   +3 more
doaj   +1 more source

Parametric Study on How the Lateral Forces Acting on a Deep Foundation Influences the Axial Forces Developing in the Piles

Romanian Journal of Transport Infrastructure, 2017
A missing piece in the design of bridge substructure is that the equation given in structural mechanics that assesses the axial forces in the piles of a deep foundation does not take into account the effect of lateral forces acting on the pile cap.
Iordănescu Radu Adrian
doaj   +1 more source

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes

FEBS Letters, EarlyView.
GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg, Martine Hjeltnes, Josephine Krieger, Joshua E. Elias, Maria Stensland, Kristian Holm, Xiaojun Jiang, Chuki Khangsar, Tuula A. Nyman, Arthur Kaser, Johannes R. Hov, Tom H. Karlsen, Nicole C. Kaneider, Frode L. Jahnsen, Georg Schneditz   +14 more
wiley   +1 more source

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Numerical Modelling of Factors Critical to Slope Stability with Plaxis 2D

Mehran University Research Journal of Engineering and Technology
Slope instability is among the primary issues in geotechnical engineering that can result in loss of life and property. This study assessed slope stability by Factor of Safety (FOS) in FEM Plaxis 2D software with different geotechnical and hydrological ...
Muhammad Rehan Hakro, Imtiaz Ali Hakro, Rabia Soomro, Faisal Ahmed Rajper, Shehnaz Hakro   +4 more
doaj   +1 more source

Optimized dimensioning of steel-concrete composite beams

Revista IBRACON de Estruturas e Materiais, 2019
The steel-concrete composite sections are often used in civil building in Brazil and around the world. The connection of the steel profile and the concrete slab increases the performance of the composite structural element due to the use of the ...
A. R. SILVA, T. A. RODRIGUES
doaj   +2 more sources