Results 31 to 40 of about 572,234 (311)

Pilot Implementation: Testing Human-Work Interaction Designs

, 2021
Pilot implementations are field tests of properly engineered, yet unfinished, systems. In contrast to lab tests, the users in a pilot implementation use the system for performing real work. In contrast to full-scale implementations, the objective of a pilot implementation is to learn.
Morten Hertzum, Torkil Clemmensen, Barbara Rita Barricelli, Pedro F. Campos, Frederica Gonçalves, José L. Abdelnour-Nocera, Ganesh Bhutkar, Arminda Guerra Lopes   +7 more
openaire   +5 more sources

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

FEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho, Shin Morioka, Junko Sasaki, Takehiko Sasaki   +3 more
wiley   +1 more source

Applying 3D scanning and modeling in transport design education

, 2006
Advanced 3D Laser Scanning processes have developed over the last decade and are now available and affordable for medium to large companies as well as education.
Unver, Ertu, Atkinson, Paul, Tancock, Dave, Tancock, David   +3 more
core   +1 more source

Pilot Design and Piloting plan (v1.0)

, 2022
The objective of WP2 “Tracking hazards and potential measures” is define and outline the piloting settings so as to track the potential hazards across the Bluebio value chain affecting food quality and safety along three crucial value chains in Europe, and more precisely: 1) the Atlantic salmon value chain, 2) the Atlantic whitefish value chain, and 3)
Nychas, George-John, Lerfall, Jørgen, Jakobsen, Anita Nordeng, Guðjónsdóttir, María, Sveinsdottir, Hildur Inga, Shultz, Nette   +5 more
openaire   +1 more source

pH‐mediated activation of the lysosomal arginine sensor SLC38A9

FEBS Letters, EarlyView.
Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley   +1 more source

Retraining function in people with Parkinson’s disease using the Microsoft kinect: game design and pilot testing [PDF]

, 2014
Background Computer based gaming systems, such as the Microsoft Kinect (Kinect), can facilitate complex task practice, enhance sensory feedback and action observation in novel, relevant and motivating modes of exercise which can be difficult to ...
Madeline Balaam, Dadirayi Mhiripiri, Scholfield, Guy, Galna, Brook, Jackson, Dan, Brook Galna, Balaam, M., Gillian Barry, Jackson, Daniel, Galna, B., Roisin McNaney, Rochester, Lynn, McNaney, Roisin, Schofield, G., Lynn Rochester, Dan Jackson, Schofield, Guy, Webster, M., Mhiripiri, Dadirayi, Mary Webster, McNaney, R., Jackson, D., Balaam, Madeline,, Mhiripiri, D., Patrick Olivier, Webster, Mary, Balaam, Madeline, Olivier, P., Rochester, L., Olivier, Patrick, Barry, G., Barry, Gillian, Guy Schofield   +32 more
core   +1 more source

Identification of a Shiga toxin A‐derived peptide internalized into Gb3 receptor‐bearing cells via interaction with the Shiga toxin B subunit

FEBS Letters, EarlyView.
The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi, João C. Encarnação, Valeria Napolitano, Grzegorz Dubin, Grzegorz Popowicz, Karl Andersson, U. Helena Danielson   +6 more
wiley   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

The Importance of Pilot Studies [PDF]

, 2001
The term 'pilot studies' refers to mini versions of a full-scale study (also called 'feasibility' studies), as well as the specific pre-testing of a particular research instrument such as a questionnaire or interview schedule.
Hundley, Vanora, van Teijlingen, Edwin R., van Teijlingen, Edwin   +2 more
core  

Questions asked and answered in pilot and feasibility randomized controlled trials

, 2011
Background In the last decade several authors have reviewed the features of pilot and feasibility studies and advised on the issues that should be addressed within them.
Shanyinde Milensu, Shanyinde, Milensu, Shanyinde, M, Weatherall, M., Weatherall, M, Mark Weatherall, Ruth M Pickering, Pickering, R.M., Shanyinde, M., Pickering Ruth M, Weatherall Mark, Pickering, RM, Milensu Shanyinde   +12 more
core   +2 more sources