Results 41 to 50 of about 911,084 (283)

A large‐scale retrospective study in metastatic breast cancer patients using circulating tumour DNA and machine learning to predict treatment outcome and progression‐free survival

open access: yesMolecular Oncology, EarlyView.
There is an unmet need in metastatic breast cancer patients to monitor therapy response in real time. In this study, we show how a noninvasive and affordable strategy based on sequencing of plasma samples with longitudinal tracking of tumour fraction paired with a statistical model provides valuable information on treatment response in advance of the ...
Emma J. Beddowes   +20 more
wiley   +1 more source

Aerodynamics, Stability and Control of the 1903 Wright Flyer [PDF]

open access: yes, 1985
The Los Angeles Chapter of the American Institute of Aero and Astronautics is building two replicas of the 1903 Wright Flyer airplane; one to wind-tunnel test and display, and a modified one to fly.
Culick, Fred E. C., Jex, Henry R.
core  

Can food security and low carbon be achieved simultaneously? —An empirical analysis of the mechanisms influencing the carbon footprint of potato and corn cultivation in irrigation areas

open access: yesJournal of Integrative Agriculture, 2023
Irrigated agriculture has tripled since 1950, accounting for 20% of the global arable land and 40% of food production. Irrigated agriculture increases food security yet has controversial implications for global climate change.
Kun-yu NIU, Hui GUO, Jing LIU
doaj  

Time, the final frontier

open access: yesMolecular Oncology, EarlyView.
This article advocates integrating temporal dynamics into cancer research. Rather than relying on static snapshots, researchers should increasingly consider adopting dynamic methods—such as live imaging, temporal omics, and liquid biopsies—to track how tumors evolve over time.
Gautier Follain   +3 more
wiley   +1 more source

Homebound: STS-M1301 A Study on Television Writing in the Science Fiction Genre [PDF]

open access: yes, 2019
This project is a scene-by-scene outline of an original television pilot script in the science fiction genre. The outline is based on research conducted in both the television and science fiction fields, providing the project with a firm foundation in ...
Crouch, Matthew
core   +1 more source

Exploration on the Training and Evaluation Mode of Clinical Postdoctoral Trainees in Radiology Department Based on Core Competence

open access: yesXiehe Yixue Zazhi, 2022
The postdoctoral training program of clinical medicine explores a new form of medical elite education in China. As one of the first pilot departments of the clinical postdoctoral program of Peking Union Medical College Hospital, Radiology Department has ...
CHEN Yu   +9 more
doaj   +1 more source

Therapeutic applications of a novel humanized monoclonal antibody targeting chemokine receptor CCR9 in pancreatic cancer

open access: yesMolecular Oncology, EarlyView.
C–C chemokine receptor type 9 (CCR9) is an immune checkpoint in pancreatic ductal adenocarcinoma (PDAC). Novel anti‐CCR9 antibody SRB2 was evaluated in combination with cytotoxic chemotherapy in PDAC cells, patient‐derived organoids, patient‐derived xenografts, and humanized mouse models.
Hannah G. McDonald   +18 more
wiley   +1 more source

Unveiling unique protein and phosphorylation signatures in lung adenocarcinomas with and without ALK, EGFR, and KRAS genetic alterations

open access: yesMolecular Oncology, EarlyView.
Proteomic and phosphoproteomic analyses were performed on lung adenocarcinoma (LUAD) tumors with EGFR, KRAS, or EML4–ALK alterations and wild‐type cases. Distinct protein expression and phosphorylation patterns were identified, especially in EGFR‐mutated tumors. Key altered pathways included vesicle transport and RNA splicing.
Fanni Bugyi   +12 more
wiley   +1 more source

Beyond digital twins: the role of foundation models in enhancing the interpretability of multiomics modalities in precision medicine

open access: yesFEBS Open Bio, EarlyView.
This review highlights how foundation models enhance predictive healthcare by integrating advanced digital twin modeling with multiomics and biomedical data. This approach supports disease management, risk assessment, and personalized medicine, with the goal of optimizing health outcomes through adaptive, interpretable digital simulations, accessible ...
Sakhaa Alsaedi   +2 more
wiley   +1 more source

Options for Climate-Smart Agriculture at Kaptumo Site in Kenya [PDF]

open access: yes, 2014
This report identifies and assesses climate-smart agricultural practices through participatory appraisal tools with experts and farmers, as part of the MICCA pilot project in Kaptumo, Kenya.
Charles Wambugu   +2 more
core   +1 more source

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