Results 51 to 60 of about 5,556,355 (385)

PARP inhibitors elicit distinct transcriptional programs in homologous recombination competent castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
PARP inhibitors are used to treat a small subset of prostate cancer patients. These studies reveal that PARP1 activity and expression are different between European American and African American prostate cancer tissue samples. Additionally, different PARP inhibitors cause unique and overlapping transcriptional changes, notably, p53 pathway upregulation.
Moriah L. Cunningham, Jasibel Vasquez‐Gonzalez, Samantha M. Barnada, Salome Tchotorlishvili, Latese Jones, Ryan Maguire, Genevieve Lewis, Kinza Rizwan, Jenny Deng, Salma Koachar, Drithi Patel, Hailey Shankle, Tessa Mulders, Namra Ajmal, Charalambos Solomides, Emad S. Alnemri, Teresa F. Alnemri, Ayesha A. Shafi, Leonard G. Gomella, Wm Kevin Kelly, Steven B. McMahon, Matthew J. Schiewer   +21 more
wiley   +1 more source

Pilot Federated Analysis Projects

International Journal of Population Data Science
The Cambrian explosion of Trusted Research Environments (TREs) will inevitably lead to increased data siloing and potentially decrease achievable data science.  Federated access to data is a mitigation against this risk.  The presentation will cover two
Simon Thompson
doaj   +1 more source

A Pilot Study of Endoscopic Submucosal Dissection Using an Endoscopic Assistive Robot in a Porcine Stomach Model

Gut and Liver, 2019
Background/AimsEndoscopic assistive devices have been developed to reduce the complexity and improve the safety of surgeries involving the use of endoscopes.
Byung Gon Kim, Hyuk Soon Choi, Sei Hoon Park, Jun Ho Hong, Jung Min Lee, Seung Han Kim, Hoon Jai Chun, Daehie Hong, Bora Keum   +8 more
doaj   +1 more source

Landslide risk reduction through close partnership between research, industry, and public entities in Norway: Pilots and case studies

Frontiers in Earth Science, 2022
Cross-sectorial and cross-disciplinary collaboration, as well as public-private partnerships are necessary to handle the complexity of climate adaptation.
Anders Solheim, Bjørn Kalsnes, James Strout, Luca Piciullo, Håkon Heyerdahl, Unni Eidsvig, Jardar Lohne   +6 more
doaj   +1 more source

The Arctic Pilot Project

Energy Exploration & Exploitation, 1983
The Arctic Pilot Project (APP) is a transportation system designed to deliver 7.6 × 106 m3/day of natural gas from Melville Island in the Arctic Islands to a terminal location in Eastern Canada on a year-round basis using icebreaking liquefied natural gas (LNG) carriers.
openaire   +1 more source

Cycling and Health Innovative Pilot Projects (Executive summary) [PDF]

, 2010
The Cycling and Health Innovative Pilot Project (CHIPPS) provided cycle training for adults in Nottingham and Northamptonshire from 2007 to 2010. The Primary Care Trusts in each area have delivered these projects in collaboration with partners.
Ingle, L, Long, JA, Rivett, M
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Bridging the gap: Multi‐stakeholder perspectives of molecular diagnostics in oncology

Molecular Oncology, EarlyView.
Although molecular diagnostics is transforming cancer care, implementing novel technologies remains challenging. This study identifies unmet needs and technology requirements through a two‐step stakeholder involvement. Liquid biopsies for monitoring applications and predictive biomarker testing emerge as key unmet needs. Technology requirements vary by
Jorine Arnouts, Senada Koljenović, Elise Daems, Karolien De Wael, Marc Peeters, Léon C. van Kempen, Greetje Vanhoutte, Karen Zwaenepoel, Timon Vandamme   +8 more
wiley   +1 more source

Novel Multicomponent Digital Care Assistant and Support Program for People After Stroke or Transient Ischaemic Attack: A Pilot Feasibility Study

Sensors
Evidence is increasing for digital health programs targeting the secondary prevention of stroke. We aimed to determine the feasibility of the novel Care Assistant and support Program for people after Stroke (CAPS) or transient ischaemic attack (TIA) by ...
Liam P. Allan, David Silvera-Tawil, Jan Cameron, Jane Li, Marlien Varnfield, Vanessa Smallbon, Julia Bomke, Muideen T. Olaiya, Natasha A. Lannin, Dominique A. Cadilhac   +9 more
doaj   +1 more source

Cochlear Implant Receiver Location and Migration: Experimental Validation Pilot Study of a Clinically Applicable Screening Method

Frontiers in Surgery, 2020
Objectives: Postoperative follow-up after cochlear implantation lacks a reliable screening method to detect cochlear implant receiver device migration. This study aims to validate a clinically applicable method to assess the position and migration of the
Laura M. Markodimitraki, Laura M. Markodimitraki, Inge Stegeman, Inge Stegeman, Adriana L. Smit, Adriana L. Smit, Hans G. X. M. Thomeer, Hans G. X. M. Thomeer   +7 more
doaj   +1 more source

From Volume to Value: Transforming Health Care Payment and Delivery Systems to Improve Quality and Reduce Costs [PDF]

, 2008
Summarizes presentations on the changes in payment systems and organizational structures required to provide higher-quality health care, including episode-of-care payments for major acute episodes.

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