Results 51 to 60 of about 827,748 (311)

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

open access: yesMolecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch   +13 more
wiley   +1 more source

The Individual Budgets Pilot Projects: Impact and Outcomes for Carers [PDF]

open access: yes, 2009
All rights reserved. Reproduction of this report by photocopying or electronic means for non-commercial purposes is permitted. Otherwise, no part of this report may be reproduced, adapted, stored in a retrieval system or transmitted by any means ...
Arksey, Hilary   +5 more
core  

Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

open access: yesMolecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute   +4 more
wiley   +1 more source

Clinical outcomes of the pilot project Nephrology Liaison Clinic in a primary care clinic: A retrospective observational study [PDF]

open access: yesMalaysian Family Physician
Introduction: The pilot project Nephrology Liaison Clinic, initiated in 2019 at Klinik Kesihatan Sentul, integrates nephrology services into primary care.
Tiong Lim Low   +4 more
doaj   +1 more source

Methodological and theoretical framework mapping commonalities and differences of separate pilot study action plans onto a common framework of actions and guiding principles [PDF]

open access: yes, 2014
The individual action plans from the pilot projects differ across project partners for a variety of locally specific reasons. In order to later compare the results from the different pilot projects, it is essential to have a clear understanding of the ...
Bayer, J., Komendantova, N., Patt, A.
core  

A learning tool to develop sustainable projects [PDF]

open access: yes, 2016
This paper presents a tool developed to help engineers to design and develop sustainable projects. The tool has been designed to introduce and evaluate the sustainability of engineering projects in general, but here we show its application to assess the ...
Alier Forment, Marc   +6 more
core   +1 more source

The GEOSS interoperability process pilot project [PDF]

open access: yes2007 IEEE International Geoscience and Remote Sensing Symposium, 2007
GEOSS, the Global Earth Observing System of Systems, is being built from existing systems and initiatives, with an emphasis on the creation of synergies among GEOSS component that provide increased benefits to society. The goal is to leverage existing programs and established standards wherever possible, and to broaden convergence of systems based on ...
Siri Jodha Singh Khalsa   +4 more
openaire   +3 more sources

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

open access: yesMolecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova   +14 more
wiley   +1 more source

23rd Annual Meeting of the German Society for Newborn Screening (Deutsche Gesellschaft für Neugeborenenscreening, DGNS)

open access: yesInternational Journal of Neonatal Screening, 2016
From 3–4 June, 2016, the 23rd Annual Meeting of the German Society for Newborn Screening (Deutsche Gesellschaft für Neugeborenenscreening, DGNS) was held at the University Hospital Heidelberg. The meeting was organized by PD Dr. med.
Gwendolyn Gramer   +2 more
doaj   +1 more source

The application of a pilot pull planning system to construction projects [PDF]

open access: yes, 2002
A new planning system was introduced as a pilot within a large UK construction company. The system, which attempts to address some of the problems of construction “front end” planning, is investigated relative to Lean Construction and specifically the ...
Johansen, Eric
core  

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