Results 161 to 170 of about 26,558 (201)

Structural mechanisms of PIP₂ activation and SEA0400 inhibition in human cardiac sodium-calcium exchanger NCX1. [PDF]

Elife
Xue J, Zeng W, John S, Attiq N, Ottolia M, Jiang Y.   +5 more
europepmc   +1 more source

Lipid-lncRNA Crossroads: An Overview of Interactions Between Lipids and lncRNA. [PDF]

Cells
Bayona-Hernandez A, Miladinović A, Antiga L, Hozak P, Sztacho M, Castano E.   +5 more
europepmc   +1 more source

Conformational Dynamics and Activation of Membrane-Associated Human Group IVA Cytosolic Phospholipase A₂ (cPLA₂). [PDF]

J Phys Chem Lett
Braza MKE, Dennis EA, Amaro RE.
europepmc   +1 more source

Mechanism of phosphoinositide regulation of lysosomal pH via inhibition of CLC-7

Hilton JK, Lin Y, Sefah E, Deme JC, Parker JL, Langton MJ, Grabe M, Lea S, Newstead S, Mindell JA.   +9 more
europepmc   +1 more source

Ion channels - Exciting times for PIP2

, 2016
openaire   +1 more source

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Cholesterol and PIP2 Modulation of BKCa Channels

2023
Ca2+/voltage-gated, large conductance K+ channels (BKCa) are formed by homotetrameric association of α (slo1) subunits. Their activity, however, is suited to tissue-specific physiology largely due to their association with regulatory subunits (β and γ types), chaperone proteins, localized signaling, and the channel's lipid microenvironment.
Thirumalini, Vaithianathan, Elizabeth H, Schneider, Anna N, Bukiya, Alex M, Dopico   +3 more
openaire   +2 more sources

Vesicle transport: Exocyst follows PIP2 to tether membranes

Current Biology, 2022
A new study uses reconstituted, functional octameric exocyst complex to provide new insights into the assembly of this tethering complex and reveal how the activity of the lipid kinase PIP5K1C stimulated by Arf6 on exocytic vesicles allows for exocyst-mediated tethering at the plasma membrane.
Lars, Langemeyer, Christian, Ungermann
openaire   +2 more sources

Regulation of ThermoTRP Channels by PIP2 and Cholesterol

2023
Transient receptor potential (TRP) ion channels are proteins that are expressed by diverse tissues and that play pivotal functions in physiology. These channels are polymodal and are activated by several stimuli. Among TRPs, some members of this family of channels respond to changes in ambient temperature and are known as thermoTRPs.
Tamara, Rosenbaum, Sara L, Morales-Lázaro   +1 more
openaire   +2 more sources

The multifaceted role of PIP2 in leukocyte biology

Cellular and Molecular Life Sciences, 2015
Phosphatidylinositol 4,5-bisphosphate (PIP2) represents about 1 % of plasma membrane phospholipids and behaves as a pleiotropic regulator of a striking number of fundamental cellular processes. In recent years, an increasing body of literature has highlighted an essential role of PIP2 in multiple aspects of leukocyte biology.
TUOSTO, Loretta, CAPUANO, CRISTINA, MUSCOLINI, MICHELA, SANTONI, Angela, GALANDRINI, Ricciarda   +4 more
openaire   +3 more sources

PIP2 and Talin Join Forces to Activate Integrin

The Journal of Physical Chemistry B, 2015
Integrins are major players in cell adhesion and migration, and malfunctions in controlling their activity are associated with various diseases. Nevertheless, the details of integrin activation are not completely understood, and the role of lipids in the process is largely unknown. Herein, we show using atomistic molecular dynamics simulations that the
Adam Orłowski, Sampo Kukkurainen, Annika Pöyry, Sami Rissanen, Ilpo Vattulainen, Vesa P. Hytönen, Tomasz Róg   +6 more
openaire   +3 more sources