Results 91 to 100 of about 1,796,810 (372)
Molecular Oncology, EarlyView.This study characterizes the responses of primary acute myeloid leukemia (AML) patient samples to the MCL‐1 inhibitor MIK665. The results revealed that monocytic differentiation is associated with MIK665 sensitivity. Conversely, elevated ABCB1 expression is a potential biomarker of resistance to the treatment, which can be overcome by the combination ...
Joseph Saad +17 more
wiley +1 more source
You-qi chuyun, 2020 RMG512 self-operated monitoring regulator, a key offtake device, has been widely used in China's gas transmission pipeline offtake stations. With the promotion of "centralized monitoring" production management mode in stations, higher requirements have ...
Lijun ZHONG +7 more
doaj +1 more source
Repurposed agents in the Alzheimer’s disease drug development pipeline
Alzheimer's Research & Therapy, 2020 Treatments are needed to address the growing prevalence of Alzheimer’s disease (AD). Clinical trials have failed to produce any AD drugs for Food and Drug Administration (FDA) approval since 2003, and the pharmaceutical development process is both time ...
J. Bauzon, Garam Lee, J. Cummings
semanticscholar +1 more source
Molecular Oncology, EarlyView.Plasma‐based detection of actionable mutations is a promising approach in lung cancer management. Analysis of ctDNA with a multigene NGS panel identified TP53, KRAS, and EGFR as the most frequently altered, with TP53 and KRAS in treatment‐naïve patients and TP53 and EGFR in previously treated patients.
Giovanna Maria Stanfoca Casagrande +11 more
wiley +1 more source
You-qi chuyun, 2022 The equal outer diameter design(the inner-tapered bevel design) of onshore high-grade large-diameter natural gas pipelines has effectively improved the quality problems of welding at place of pipeline with unequal wall thickness.However, the problems ...
YANG Ming +6 more
doaj +1 more source
Judge Parker and the Public Service State [PDF]
, 1985 The work described in this thesis is part of the Open Space project, a collaboration between Linköping University, NASA and the American Museum of Natural History.
Fish, Peter G.
core +1 more source
Extending Seqenv: a taxa-centric approach to environmental annotations of 16S rDNA sequences [PDF]
, 2017 Understanding how the environment selects a given taxon and the diversity patterns that emerge as a result of environmental filtering can dramatically improve our ability to analyse any environment in depth as well as advancing our knowledge on how the ...
Hamonts, Kelly +4 more
core +3 more sources
Aggressive prostate cancer is associated with pericyte dysfunction
Molecular Oncology, EarlyView.Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero +11 more
wiley +1 more source
Vibration diagnosis method of oil pump inlet and outlet pipes
You-qi chuyun, 2021 The vibration of oil pump set and its inlet and outlet pipes during their operation is one of the main threats to the safe and stable operation of pipeline. Herein, the source of excitation force and the vibration causes of pipeline system were analyzed,
Baisong LI +4 more
doaj +1 more source
CEGMA: a pipeline to accurately annotate core genes in eukaryotic genomes
Bioinform., 2007 MOTIVATION The numbers of finished and ongoing genome projects are increasing at a rapid rate, and providing the catalog of genes for these new genomes is a key challenge.
Genís Parra, K. Bradnam, I. Korf
semanticscholar +1 more source