Results 101 to 110 of about 3,711,584 (360)

A comprehensive proteogenomic pipeline for neoantigen discovery to advance personalized cancer immunotherapy

Nature Biotechnology
The accurate identification and prioritization of antigenic peptides is crucial for the development of personalized cancer immunotherapies. Publicly available pipelines to predict clinical neoantigens do not allow direct integration of mass spectrometry ...
Florian Huber, M. Arnaud, Brian J Stevenson, Justine Michaux, Fabrizio Benedetti, Jonathan Thevenet, S. Bobisse, Johanna Chiffelle, Talita Gehert, Markus Müller, HuiSong Pak, Anne I Krämer, Emma Ricart Altimiras, Julien Racle, Marie Taillandier-Coindard, Katja Muehlethaler, Aymeric Auger, Damien Saugy, Baptiste Murgues, Abdelkader Benyagoub, D. Gfeller, D. D. Laniti, L. Kandalaft, Blanca Navarro Rodrigo, H. Bouchaab, S. Tissot, G. Coukos, A. Harari, M. Bassani-Sternberg   +28 more
semanticscholar   +1 more source

Dihydroorotate dehydrogenase (DHODH) regulates trophoblast syncytialization through organelle stress–induced cellular senescence

FEBS Open Bio, EarlyView.
The inhibition of mitochondrial dihydroorotate dehydrogenase (DHODH) impairs syncytialization and induces cellular senescence via mitochondrial and endoplasmic reticulum stress in human trophoblast stem cells, elevating sFlt1/PlGF levels, a hallmark of placental dysfunction in hypertensive disorders of pregnancy.
Kanoko Yoshida, Kazuya Kusama, Ayaka Horiuchi, Yu Kawaguchi, Atsuya Tsuru, Mikihiro Yoshie, Kazuhiro Tamura   +6 more
wiley   +1 more source

A metamorphic robot suitable for rigid miniature pipelines

Jixie chuandong
ObjectiveTo address the limited adaptability of traditional pipeline robots in complex working environments, a design proposal for a shape memory alloy (SMA) driven peristaltic metamorphic robot suitable for rigid miniature pipelines was presented ...
JIA Xiaoli, DAI Jingting, MI Baichuan, DAN Jiale, KE Liaoliang   +4 more
doaj   +2 more sources

From reads to genes to pathways: differential expression analysis of RNA-Seq experiments using Rsubread and the edgeR quasi-likelihood pipeline

F1000Research, 2016
In recent years, RNA sequencing (RNA-seq) has become a very widely used technology for profiling gene expression. One of the most common aims of RNA-seq profiling is to identify genes or molecular pathways that are differentially expressed (DE) between ...
Yunshun Chen, Aaron T. L. Lun, G. Smyth
semanticscholar   +1 more source

Lesion Location and Functional Connections Reveal Cognitive Impairment Networks in Multiple Sclerosis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Cognitive impairment, fatigue, and depression are common in multiple sclerosis (MS), potentially due to disruption of regional functional connectivity caused by white matter (WM) lesions. We explored whether WM lesions functionally connected to specific brain regions contribute to these MS‐related manifestations.
Alessandro Franceschini, Paolo Preziosa, Paola Valsasina, Damiano Mistri, Monica Margoni, Federica Esposito, Massimo Filippi, Maria A. Rocca   +7 more
wiley   +1 more source

Morphable Face Models - An Open Framework

, 2017
In this paper, we present a novel open-source pipeline for face registration based on Gaussian processes as well as an application to face image analysis.
Blumer, Clemens, Egger, Bernhard, Gerig, Thomas, Lüthi, Marcel, Morel-Forster, Andreas, Schönborn, Sandro, Vetter, Thomas   +6 more
core   +1 more source

CSF Levels of NPTX2 Are Associated With Less Brain Atrophy Over Time in Cognitively Unimpaired Individuals

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Introduction Neuronal pentraxin 2 (NPTX2) is a synaptic protein involved in synaptic plasticity and regulation of neuronal excitability. Lower baseline cerebrospinal fluid (CSF) NPTX2 levels have been shown to be associated with an earlier onset of mild cognitive impairment (MCI), a pre‐dementia syndrome, even after CSF Alzheimer's Disease (AD)
Juan P. Vazquez, Corinne Pettigrew, Yuxin Zhu, Claire Anderson, Guray Erus, Christos Davatzikos, Michael Miller, Abhay Moghekar, Sungtaek Oh, Chan‐Hyun Na, Marilyn Albert, Paul Worley, Anja Soldan   +12 more
wiley   +1 more source

Lessons Learned: Quality Analysis of Optical Coherence Tomography in Neuromyelitis Optica

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Introduction Optical coherence tomography (OCT)‐derived retina measurements are markers for neuroaxonal visual pathway status. High‐quality OCT scans are essential for reliable measurements, but their acquisition is particularly challenging in eyes with severe visual impairment, as often observed in neuromyelitis optica spectrum disorders ...
Hadi Salih, Sara Samadzadeh, Charlotte Bereuter, Seyedamirhosein Motamedi, Claudia Chien, Pablo Villoslada, Hadas Stiebel‐Kalish, Nasrin Asgari, Yang Mao‐Draayer, Marius Ringelstein, Joachim Havla, Marco Aurélio Lana Peixoto, Ho Jin Kim, Jacqueline Palace, Maria Isabel Leite, Srilakshmi M. Sharma, Fereshteh Ashtari, Rahele Kafieh, Lekha Pandit, Orhan Aktas, Philipp Albrecht, Letizia Leocani, Itay Lotan, Sasitorn Siritho, Jérôme de Seze, Romain Marignier, Caroline Froment Tilikete, Denis Bernardi Bichuetti, Ivan Maynart Tavares, Ayse Altintas, Anu Jacob, Saif Huda, Ibis Soto de Castillo, Lawrence J. Cook, Michael R. Yeaman, Axel Petzold, Alexander U. Brandt, Friedemann Paul, Frederike C. Oertel, Hanna G. Zimmermann, with the Guthy Jackson Charitable Foundation—International Clinical Consortium and CROCTINO Collaborators   +40 more
wiley   +1 more source

The emergence and importance of DevSecOps: Integrating and reviewing security practices within the DevOps pipeline

World Journal of Advanced Engineering Technology and Sciences
The emergence of DevSecOps marks a significant paradigm shift in software development, focusing on integrating security practices seamlessly into the DevOps pipeline.
Oluwatosin Abiona, Oluwatayo Jacob Oladapo, Oluwole Temidayo Modupe, Oyekunle Claudius Oyeniran, Adebunmi Okechukwu Adewusi, Abiola Moshood Komolafe   +5 more
semanticscholar   +1 more source

Network Localization of Fatigue in Multiple Sclerosis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Fatigue is among the most common symptoms and one of the main factors determining the quality of life in multiple sclerosis (MS). However, the neurobiological mechanisms underlying fatigue are not fully understood. Here we studied lesion locations and their connections in individuals with MS, aiming to identify brain networks ...
Olli Likitalo, Jaakko Kungshamn, Albert Bellmunt‐Gil, Silvia Tommasin, Abhineet Ojha, Matias Viitala, Juho Aaltonen, Jyrki Lötjönen, Juha Koikkalainen, Pauli Ylikotila, Patrizia Pantano, Merja Soilu‐Hänninen, Juho Joutsa   +12 more
wiley   +1 more source