Results 41 to 50 of about 630,474 (269)

Judge Parker and the Public Service State [PDF]

, 1985
The work described in this thesis is part of the Open Space project, a collaboration between Linköping University, NASA and the American Museum of Natural History.
Fish, Peter G.
core   +1 more source

APECS - The Atacama Pathfinder Experiment Control System [PDF]

, 2006
APECS is the distributed control system of the new Atacama Pathfinder EXperiment (APEX) telescope located on the Llano de Chajnantor at an altitude of 5107 m in the Atacama desert in northern Chile. APECS is based on Atacama Large Millimeter Array (ALMA)
A. Belloche, C. König, D. Muders, E. Polehampton, F. Schuller, F. van der Tak, F. Wyrowski, Greisen, Güsten, H. Hafok, Heyminck, J. Hatchell, Klein, R. Schaaf, Wells   +14 more
core   +3 more sources

Methylation biomarkers can distinguish pleural mesothelioma from healthy pleura and other pleural pathologies

Molecular Oncology, EarlyView.
We developed and validated a DNA methylation–based biomarker panel to distinguish pleural mesothelioma from other pleural conditions. Using the IMPRESS technology, we translated this panel into a clinically applicable assay. The resulting two classifier models demonstrated excellent performance, achieving high AUC values and strong diagnostic accuracy.
Janah Vandenhoeck, Nele De Meulenaere, Thomas Vanpoucke, Joe Ibrahim, Dieter Peeters, Suresh Krishan Yogeswaran, Wen Wen, Paul Van Schil, Jeroen M. H. Hendriks, Jo Raskin, Jan van Meerbeeck, Guy Van Camp, Ken Op de Beeck   +12 more
wiley   +1 more source

Application of oil and gas pipeline network simulation technologies in construction of intelligent pipeline network and its prospect

You-qi chuyun, 2023
An accurate description of pipeline network characteristics and behaviors is required for the construction of intelligent pipeline networks. With the rapid development and application of intelligent pipeline networks, simulation technology has become ...
Jing GONG, Bohui SHI, Xiaoping LI, Weichao YU, Haihao WU   +4 more
doaj   +1 more source

ATF4‐mediated stress response as a therapeutic vulnerability in chordoma

Molecular Oncology, EarlyView.
We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone, James Dunford, Eleanor Calcutt, Vicki Gamble, Filiz Senbabaoglu Aksu, Lorena Ligammari, Georgina Wherry, Giorgia Gaeta, John C. Christianson, Adrienne M. Flanagan, Udo Oppermann, Adam P. Cribbs   +11 more
wiley   +1 more source

TRIP - T cell receptor/immunoglobulin profiler

BMC Bioinformatics, 2020
Background Antigen receptors are characterized by an extreme diversity of specificities, which poses major computational and analytical challenges, particularly in the era of high-throughput immunoprofiling by next generation sequencing (NGS). The T cell
Maria Th. Kotouza, Katerina Gemenetzi, Chrysi Galigalidou, Elisavet Vlachonikola, Nikolaos Pechlivanis, Andreas Agathangelidis, Raphael Sandaltzopoulos, Pericles A. Mitkas, Kostas Stamatopoulos, Anastasia Chatzidimitriou, Fotis E. Psomopoulos, on behalf of the Hellenic Precision Medicine Network in Oncology   +11 more
doaj   +1 more source

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

Dynamic Behavior of the Deepwater Flexible Pipeline during Pipe Laying Process

Journal of Marine Science and Engineering, 2020
The dynamic behavior of the flexible pipeline during deepwater Flex-lay directly determines the structures of laying facilities and the actual installation process.
Liquan Wang, Ming Ju, Xiaodong Xing, Feihong Yun, Xiangyu Wang   +4 more
doaj   +1 more source

Neuroimaging study designs, computational analyses and data provenance using the LONI pipeline. [PDF]

, 2010
Modern computational neuroscience employs diverse software tools and multidisciplinary expertise to analyze heterogeneous brain data. The classical problems of gathering meaningful data, fitting specific models, and discovering appropriate analysis and ...
Chakrapani, Shruthi, Dinov, Ivo, Eggert, Paul, Gutman, Boris, Leung, Kelvin, Liu, Zhizhong, Lozev, Kamen, Magsipoc, Rico, Parker, D Stott, Petrosyan, Petros, Pierce, Jonathan, Toga, Arthur, Van Horn, John, Woods, Roger, Zamanyan, Alen   +14 more
core   +3 more sources

Crucial parameters for precise copy number variation detection in formalin‐fixed paraffin‐embedded solid cancer samples

Molecular Oncology, EarlyView.
This study shows that copy number variations (CNVs) can be reliably detected in formalin‐fixed paraffin‐embedded (FFPE) solid cancer samples using ultra‐low‐pass whole‐genome sequencing, provided that key (pre)‐analytical parameters are optimized.
Hanne Goris, Vasiliki Siozopoulou, Léon C van Kempen, Anne Sieben, Ella Roelant, Stig Hellemans, Elyne Backx, Laure Sorber, Koen De Winne, Senada Koljenović, Karen Zwaenepoel   +10 more
wiley   +1 more source