Results 61 to 70 of about 637,926 (286)
FEBS Open Bio, EarlyView.The inhibition of mitochondrial dihydroorotate dehydrogenase (DHODH) impairs syncytialization and induces cellular senescence via mitochondrial and endoplasmic reticulum stress in human trophoblast stem cells, elevating sFlt1/PlGF levels, a hallmark of placental dysfunction in hypertensive disorders of pregnancy.
Kanoko Yoshida +6 more
wiley +1 more source
CVMFS: Stratum 0 in Kubernetes [PDF]
EPJ Web of Conferences, 2019 IceCube is a cubic kilometer neutrino detector located at the south pole. CVMFS is a key component to IceCube’s Distributed High Throughput Computing analytics workflow for sharing 500GB of software across datacenters worldwide.
Schultz David +3 more
doaj +1 more source
FEBS Open Bio, EarlyView.Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei +3 more
wiley +1 more source
FEBS Open Bio, EarlyView.In this study, we developed a deep learning method for mitotic figure counting in H&E‐stained whole‐slide images and evaluated its prognostic impact in 13 external validation cohorts from seven different cancer types. Patients with more mitotic figures per mm2 had significantly worse patient outcome in all the studied cancer types except colorectal ...
Joakim Kalsnes +32 more
wiley +1 more source
MethylCoder: software pipeline for bisulfite-treated sequences [PDF]
Bioinformatics, 2011 Abstract Motivation: MethylCoder is a software program that generates per-base methylation data given a set of bisulfite-treated reads. It provides the option to use either of two existing short-read aligners, each with different strengths. It accounts for soft-masked alignments and overlapping paired-end reads.
Brent, Pedersen +3 more
openaire +2 more sources
MS-DIAL: data-independent MS/MS deconvolution for comprehensive metabolome analysis. [PDF]
, 2015 Data-independent acquisition (DIA) in liquid chromatography (LC) coupled to tandem mass spectrometry (MS/MS) provides comprehensive untargeted acquisition of molecular data.
Arita, Masanori +9 more
core
Single‐molecule DNA flow‐stretch assays for high‐throughput DNA–protein interaction studies
FEBS Open Bio, EarlyView.We describe an optimised single‐molecule DNA flow‐stretch assay that visualises DNA–protein interactions in real time. Linear DNA fragments are tethered to a surface and stretched by buffer flow for fluorescence imaging. Using λ and φX174 DNA, this protocol enhances reproducibility and accessibility, providing a versatile approach for studying diverse ...
Ayush Kumar Ganguli +8 more
wiley +1 more source
Pydpiper: A Flexible Toolkit for Constructing Novel Registration Pipelines
Frontiers in Neuroinformatics, 2014 Using neuroimaging technologies to elucidate the relationship between genotype and phenotype and brain and behavior will be a key contribution to biomedical research in the twenty-first century.
Miriam eFriedel +7 more
doaj +1 more source
Simulation on Line C of the China–Central Asia Gas Pipeline based on SPS software
You-qi chuyun, 2020 The Line C of the China–Central Asia Gas Pipeline is a typical gas pipeline characterized by high transmission pressure, large flow, long pipeline span, numerous gas stations and complicated transportation technology.
Yansong LI +5 more
doaj +1 more source
FEBS Open Bio, EarlyView.This protocol paper outlines methods to establish the success of a time‐resolved serial crystallographic experiment, by means of statistical analysis of timepoint data in reciprocal space and models in real space. We show how to amplify the signal from excited states to visualise structural changes in successful experiments.
Jake Hill +4 more
wiley +1 more source