Results 71 to 80 of about 3,711,584 (360)

Off the Beaten Path: Let's Replace Term-Based Retrieval with k-NN Search

, 2016
Retrieval pipelines commonly rely on a term-based search to obtain candidate records, which are subsequently re-ranked. Some candidates are missed by this approach, e.g., due to a vocabulary mismatch.
Andoni A., Beyer K., Broder A. Z., Brown P. F., Fried D., Le Q., Mikolov T., Mu Y., Muja M., Petrović S., Riezler S., Salton G., Wang J., Weber R., Yang L., Yao X.   +15 more
core   +1 more source

Neuroimaging study designs, computational analyses and data provenance using the LONI pipeline. [PDF]

, 2010
Modern computational neuroscience employs diverse software tools and multidisciplinary expertise to analyze heterogeneous brain data. The classical problems of gathering meaningful data, fitting specific models, and discovering appropriate analysis and ...
Chakrapani, Shruthi, Dinov, Ivo, Eggert, Paul, Gutman, Boris, Leung, Kelvin, Liu, Zhizhong, Lozev, Kamen, Magsipoc, Rico, Parker, D Stott, Petrosyan, Petros, Pierce, Jonathan, Toga, Arthur, Van Horn, John, Woods, Roger, Zamanyan, Alen   +14 more
core   +3 more sources

Methylation biomarkers can distinguish pleural mesothelioma from healthy pleura and other pleural pathologies

Molecular Oncology, EarlyView.
We developed and validated a DNA methylation–based biomarker panel to distinguish pleural mesothelioma from other pleural conditions. Using the IMPRESS technology, we translated this panel into a clinically applicable assay. The resulting two classifier models demonstrated excellent performance, achieving high AUC values and strong diagnostic accuracy.
Janah Vandenhoeck, Nele De Meulenaere, Thomas Vanpoucke, Joe Ibrahim, Dieter Peeters, Suresh Krishan Yogeswaran, Wen Wen, Paul Van Schil, Jeroen M. H. Hendriks, Jo Raskin, Jan van Meerbeeck, Guy Van Camp, Ken Op de Beeck   +12 more
wiley   +1 more source

Model establishment and solution of general product pipeline scheduling

You-qi chuyun, 2020
The technical patterns for unloading of oil products at various stations along product pipelines in China can be roughly divided into four types: continuous distribution, constant flow distribution, variable flow distribution and independent planning ...
Yamin YAN, Liewu DONG, Ze REN, Jianbo WANG, Yongtu LIANG   +4 more
doaj   +1 more source

ATF4‐mediated stress response as a therapeutic vulnerability in chordoma

Molecular Oncology, EarlyView.
We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone, James Dunford, Eleanor Calcutt, Vicki Gamble, Filiz Senbabaoglu Aksu, Lorena Ligammari, Georgina Wherry, Giorgia Gaeta, John C. Christianson, Adrienne M. Flanagan, Udo Oppermann, Adam P. Cribbs   +11 more
wiley   +1 more source

Adaptability evaluation of the software for transient process simulation of supercritical CO2 pipelines

You-qi chuyun
Objective Transient processes like leakage and commissioning in CO2 pipeline operation pose simulation challenges due to the unique physical properties and phase behavior of CO2.
Xinyuan MA, Xin OUYANG, Jianlu ZHU, Junwen CHEN, Luoqian LIU, Teng YANG, Guangchun SONG   +6 more
doaj   +1 more source

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

Analysing 454 amplicon resequencing experiments using the modular and database oriented Variant Identification Pipeline

BMC Bioinformatics, 2010
Background Next-generation amplicon sequencing enables high-throughput genetic diagnostics, sequencing multiple genes in several patients together in one sequencing run.
Deforce Dieter, Coucke Paul, Van Nieuwerburgh Filip, Pattyn Filip, Sabbe Nick, Lefever Steve, De Leeneer Kim, De Schrijver Joachim M, Vandesompele Jo, Bekaert Sofie, Hellemans Jan, Van Criekinge Wim   +11 more
doaj   +1 more source

The SEGUE Stellar Parameter Pipeline. IV. Validation with an Extended Sample of Galactic Globular and Open Clusters

, 2010
Spectroscopic and photometric data for likely member stars of five Galactic globular clusters (M3, M53, M71, M92, and NGC 5053) and three open clusters (M35, NGC 2158, and NGC 6791) are processed by the current version of the SEGUE Stellar Parameter ...
Abazajian, Abazajian, Abazajian, Abazajian, Adelman-McCarthy, Adelman-McCarthy, Adelman-McCarthy, Allende Prieto, Allende Prieto, An, An, Anthony-Twarog, Barrado Y Navascués, Beers, Boesgaard, Boesgaard, Brian Yanny, Cavallo, Cohen, Cohen, Constance M. Rockosi, Craig P. Loomis, Deokkeun An, Drukier, Geller, Gratton, Gunn, Gunn, Ivezić, Jacobson, Jason P. Smolinski, Jennifer A. Johnson, Kalirai, King, Lai, Lee, Lee, Lupton, Morrison, Origlia, Pier, Ramírez, Schlegel, Sneden, Steven J. Bickerton, Stoughton, Thirupathi Sivarani, Timothy C. Beers, Wilhelm, Yanny, Young Sun Lee   +50 more
core   +1 more source

Crucial parameters for precise copy number variation detection in formalin‐fixed paraffin‐embedded solid cancer samples

Molecular Oncology, EarlyView.
This study shows that copy number variations (CNVs) can be reliably detected in formalin‐fixed paraffin‐embedded (FFPE) solid cancer samples using ultra‐low‐pass whole‐genome sequencing, provided that key (pre)‐analytical parameters are optimized.
Hanne Goris, Vasiliki Siozopoulou, Léon C van Kempen, Anne Sieben, Ella Roelant, Stig Hellemans, Elyne Backx, Laure Sorber, Koen De Winne, Senada Koljenović, Karen Zwaenepoel   +10 more
wiley   +1 more source