Results 71 to 80 of about 630,474 (269)

BMI‐1 modulation and trafficking during M phase in diffuse intrinsic pontine glioma

FEBS Open Bio, EarlyView.
The schematic illustrates BMI‐1 phosphorylation during M phase, which triggers its translocation from the nucleus to the cytoplasm. In cycling cells, BMI‐1 functions within the PRC1 complex to mediate H2A K119 monoubiquitination. Following PTC596‐induced M phase arrest, phosphorylated BMI‐1 dissociates from PRC1 and is exported to the cytoplasm via its
Banlanjo Umaru, Deepak Kumar Mishra, Shiva Senthil Kumar, Hao‐Han Pang, Brendan Devine, Komal Khan, Rachid Drissi   +6 more
wiley   +1 more source

Pydpiper: A Flexible Toolkit for Constructing Novel Registration Pipelines

Frontiers in Neuroinformatics, 2014
Using neuroimaging technologies to elucidate the relationship between genotype and phenotype and brain and behavior will be a key contribution to biomedical research in the twenty-first century.
Miriam eFriedel, Matthijs C van Eede, Jon ePipitone, M Mallar Chakravarty, M Mallar Chakravarty, M Mallar Chakravarty, Jason P Lerch, Jason P Lerch   +7 more
doaj   +1 more source

Software Pipelining of Nested Loops [PDF]

, 2001
Software pipelining is a technique to improve the performance of a loop by overlapping the execution of several iterations. The execution of a software-pipelined loop goes through three phases: prolog, kernel, and epilog. Software pipelining works best if most of the time is spent in the kernel phase rather than in the prolog or epilog phases. This can
Kalyan Muthukumar, Gautam Doshi
openaire   +1 more source

Dihydroorotate dehydrogenase (DHODH) regulates trophoblast syncytialization through organelle stress–induced cellular senescence

FEBS Open Bio, EarlyView.
The inhibition of mitochondrial dihydroorotate dehydrogenase (DHODH) impairs syncytialization and induces cellular senescence via mitochondrial and endoplasmic reticulum stress in human trophoblast stem cells, elevating sFlt1/PlGF levels, a hallmark of placental dysfunction in hypertensive disorders of pregnancy.
Kanoko Yoshida, Kazuya Kusama, Ayaka Horiuchi, Yu Kawaguchi, Atsuya Tsuru, Mikihiro Yoshie, Kazuhiro Tamura   +6 more
wiley   +1 more source

A metamorphic robot suitable for rigid miniature pipelines

Jixie chuandong
ObjectiveTo address the limited adaptability of traditional pipeline robots in complex working environments, a design proposal for a shape memory alloy (SMA) driven peristaltic metamorphic robot suitable for rigid miniature pipelines was presented ...
JIA Xiaoli, DAI Jingting, MI Baichuan, DAN Jiale, KE Liaoliang   +4 more
doaj   +2 more sources

Data Reduction Pipeline for the CHARIS Integral-Field Spectrograph I: Detector Readout Calibration and Data Cube Extraction [PDF]

, 2017
We present the data reduction pipeline for CHARIS, a high-contrast integral-field spectrograph for the Subaru Telescope. The pipeline constructs a ramp from the raw reads using the measured nonlinear pixel response, and reconstructs the data cube using ...
Brandt, Timothy D., Chilcote, Jeffrey, Currie, Thayne, Galvin, Michael, Greco, Johnny P., Groff, Tyler, Hayashi, Masahiko, Jovanovic, Nemanja, Kasdin, N. Jeremy, Knapp, Gillian, Limbach, Mary Anne, Loomis, Craig, McElwain, Michael W., Mede, Kyle, Rizzo, Maxime, Takato, Naruhisa, Tamura, Motohide   +16 more
core   +1 more source

A light‐triggered Time‐Resolved X‐ray Solution Scattering (TR‐XSS) workflow with application to protein conformational dynamics

FEBS Open Bio, EarlyView.
Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei, Fredrik Orädd, Konstantinos Magkakis, Magnus Andersson   +3 more
wiley   +1 more source

Applicability of mitotic figure counting by deep learning: a development and pan‐cancer validation study

FEBS Open Bio, EarlyView.
In this study, we developed a deep learning method for mitotic figure counting in H&E‐stained whole‐slide images and evaluated its prognostic impact in 13 external validation cohorts from seven different cancer types. Patients with more mitotic figures per mm2 had significantly worse patient outcome in all the studied cancer types except colorectal ...
Joakim Kalsnes, Maria X. Isaksen, Frida Julbø, Manohar Pradhan, Andreas Kleppe, Sepp De Raedt, Ole‐Johan Skrede, Turid Torheim, John Arne Nesheim, Hans Martin Mohn, Hanne A. Askautrud, Karolina Cyll, Wanja Kildal, Emma Rewcastle, Melinda Lillesand, Vebjørn Kvikstad, Emiel Janssen, Robert Jones, Odd Terje Brustugun, Bjørn Brennhovd, Erik Skaaheim Haug, Lill‐Tove Rasmussen Busund, Elin Richardsen, Sigve Andersen, Tom Dønnem, Kristina Lindemann, Gunnar Kristensen, Neil A. Shepherd, Marco Novelli, Knut Liestøl, David Kerr, Håvard E. Danielsen, Tarjei S. Hveem   +32 more
wiley   +1 more source

Single‐molecule DNA flow‐stretch assays for high‐throughput DNA–protein interaction studies

FEBS Open Bio, EarlyView.
We describe an optimised single‐molecule DNA flow‐stretch assay that visualises DNA–protein interactions in real time. Linear DNA fragments are tethered to a surface and stretched by buffer flow for fluorescence imaging. Using λ and φX174 DNA, this protocol enhances reproducibility and accessibility, providing a versatile approach for studying diverse ...
Ayush Kumar Ganguli, Mohammad Nour Alsamsam, Ugnė Bagdonaitė, Van Truc Vu, Chun‐Jen Huang, Polina Kuzhir, Mindaugas Zaremba, Aurimas Kopūstas, Marijonas Tutkus   +8 more
wiley   +1 more source

Animação Livre: uma proposta para uma pipeline e fluxo de trabalho baseados em Software Livre [PDF]

, 2011
OpenLab ESEV is a project of the Polytechnic Institute of Viseu’s School of Education that aims to promote, foster and support the use of Free/Libre and Open Source Software (F/LOSS), Free file formats and more flexible copyright licenses for creative ...
Figueiredo, Maria Pacheco, Gonçalves, Nelson A. F.   +1 more
core