Results 41 to 50 of about 117,524 (269)

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

A Comparative Review of Trenchless Cured-in-Place Pipe (CIPP) With Spray Applied Pipe Lining (SAPL) Renewal Methods for Pipelines

Frontiers in Water, 2022
Pipes have been used for thousands of years, the first record of copper piping dates to the Egyptians in 3000 BC. In today's time, pipelines play a dramatic role in our everyday life and is a backbone of our society.
John Hicks, Vinayak Kaushal, Koosha Jamali   +2 more
doaj   +1 more source

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

Micromachine for Locomotion Inside Pipe

Communications, 2018
The paper deals with miniature machine for locomotion inside pipe. It uses impact energy as a principle of motion. Dynamics description and simulation model has been created.
Lubica Mikova, Ivan Virgala, Michal Kelemen, Tomas Liptak, Darina Hroncova   +4 more
doaj   +1 more source

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

Analysis of Changes in Natural Gas Physical Flows for Europe via Ukraine in 2020

Energies, 2021
The main objective of the paper was comparative analyses of natural gas quantities delivered through the existing pipeline capacities in the last decade and new pipeline capacities for the prediction of possible future flows of gas import to Europe ...
Filip Božić, Daria Karasalihović Sedlar, Ivan Smajla, Ivana Ivančić   +3 more
doaj   +1 more source

Longitudinal circulating tumor DNA profiling in patients with advanced endometrial cancer using an off‐the‐shelf targeted NGS panel

Molecular Oncology, EarlyView.
Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena, Karin Teien Lande, Eva Diaz, Ana Vilar, Juan Cueva, Efigenia Arias, Victoria Sampayo, Alicia Abalo, Nerea González, Eva Colás, Antonio Gil‐Moreno, Miguel Abal, Gema Moreno‐Bueno, Therese Sørlie, Kristina Lindemann, Laura Muinelo‐Romay   +15 more
wiley   +1 more source

Development and characterization of PVC-based membranes embedded with magnetic silica core-shell composites for enhanced oil-water separation

Desalination and Water Treatment
A novel polyvinyl chloride (PVC)--based membrane incorporating magnetic silica core-shell nanoparticles (CoFe2O4@SiO2) was developed for efficient oil-water separation.
Rana H.M. EL Hady, Gheith, Mostafa M.H. Khalil, Mahmoud F. Mubarak   +3 more
doaj   +1 more source

Estimation of residual strength of pipeline's elbow with volumetric corrosion defect, which is developing

Trudy Odesskogo Politehničeskogo Universiteta, 2017
Pipelines are used as one of the most practical and low cost methods for transmission of different liquid petroleum products and gases. Damage on the pipeline is capable to appear during operation due to the accumulation of fatigue and arising of ...
Larin О. О. , Potopalska K. E.
doaj   +1 more source

Kalman Filters for Leak Diagnosis in Pipelines: Brief History and Future Research

Journal of Marine Science and Engineering, 2020
The purpose of this paper is to provide a structural review of the progress made on the detection and localization of leaks in pipelines by using approaches based on the Kalman filter. To the best of the author’s knowledge, this is the first review
Lizeth Torres, Javier Jiménez-Cabas, Omar González, Lázaro Molina and Francisco-Ronay López-Estrada   +3 more
doaj   +1 more source