Results 51 to 60 of about 117,524 (269)
Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source
Wellcome Open ResearchWe present a genome assembly from an individual female Yponomeuta evonymella (the Bird-cherry Ermine; Arthropoda; Insecta; Lepidoptera; Yponomeutidae). The genome sequence has a total length of 572.70 megabases. Most of the assembly is scaffolded into 32
Douglas Boyes, Callum Murray
doaj +1 more source
Wall-thickness reduction of AP1000 primary coolant pipes subjected to cold roll-forming
工程科学学报, 2016 A modified Johnson-Cook model was proposed based on the true stress-strain data of 316LN stainless steel and it was successfully used to describe the deformation characteristic of the steel at room temperature and low strain rate.
WANG Peng +3 more
doaj +1 more source
Tumor B‐cell infiltration in platinum‐treated advanced muscle‐invasive urothelial carcinoma
Molecular Oncology, EarlyView.Bladder tumors with higher pretreatment memory B‐cell infiltration were linked to longer survival after cisplatin chemotherapy, but not carboplatin. These tumors also showed more organized immune structures (tertiary lymphoid structures) and a shared pro‐inflammatory B‐cell‐rich community, suggesting that memory B cells may help identify patients most ...
Konrad Stawiski +10 more
wiley +1 more source
Laboratory Testing of FBGs for Pipeline Monitoring
Sensors, 2020 The monitoring of the effects of geohazards on pipelines can be addressed by optical fiber Bragg gratings (FBGs). They are sensitive to strain and bending, and are installed on the external surface of pipelines at discrete locations.
Andrea Carlino, Alberto Godio
doaj +1 more source
Molecular Oncology, EarlyView.Patient‐derived organoids (PDOs) from pancreatic, colorectal, and gastric cancers were used to evaluate standard and experimental therapies. Incorporating cancer‐associated fibroblasts (CAFs) into organoid cultures improved patient therapy outcome prediction.
Marcin Grochowski +12 more
wiley +1 more source
Известия высших учебных заведений: Нефть и газ, 2014 The problems of modeling of thermal interaction of the pipeline support pile foundation with the permafrost ground are considered. The article provides technical solutions for maintenance of the frozen condition of the grounds of pile foundations and ...
V. V. Pavlov +3 more
doaj
Journal of Engineering and Applied ScienceThis study conducts a computational fluid dynamics (CFD)-based assessment of internal corrosion risk in wet sour gas pipeline systems, focusing on developing a predictive framework for pipeline integrity. Using the L415 X60 steel pipeline as a reference,
Mavis Sika Okyere
doaj +1 more source
The anaesthesia gas supply system
Indian Journal of Anaesthesia, 2013 The anaesthesia gas supply system is designed to provide a safe, cost-effective and convenient system for the delivery of medical gases at the point of-use. The doctrine of the anaesthesia gas supply system is based on four essential principles: Identity,
Sabyasachi Das +2 more
doaj +1 more source
H2Open Journal, 2021 This study reviews the state-of-the-art application of fiber optics in water distribution networks for leak detection and localization. The use of fiber optics in the oil and gas sector has been well established; however, its potential in water pipelines
Kabir Ibrahim +3 more
doaj +1 more source