Results 51 to 60 of about 118,443 (269)
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
Wellcome Open ResearchWe present a genome assembly from an individual female Yponomeuta evonymella (the Bird-cherry Ermine; Arthropoda; Insecta; Lepidoptera; Yponomeutidae). The genome sequence has a total length of 572.70 megabases. Most of the assembly is scaffolded into 32
Douglas Boyes, Callum Murray
doaj +1 more source
Wall-thickness reduction of AP1000 primary coolant pipes subjected to cold roll-forming
工程科学学报, 2016 A modified Johnson-Cook model was proposed based on the true stress-strain data of 316LN stainless steel and it was successfully used to describe the deformation characteristic of the steel at room temperature and low strain rate.
WANG Peng +3 more
doaj +1 more source
CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3
Molecular Oncology, EarlyView.PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh +12 more
wiley +1 more source
Известия высших учебных заведений: Нефть и газ, 2014 The problems of modeling of thermal interaction of the pipeline support pile foundation with the permafrost ground are considered. The article provides technical solutions for maintenance of the frozen condition of the grounds of pile foundations and ...
V. V. Pavlov +3 more
doaj
Laboratory Testing of FBGs for Pipeline Monitoring
Sensors, 2020 The monitoring of the effects of geohazards on pipelines can be addressed by optical fiber Bragg gratings (FBGs). They are sensitive to strain and bending, and are installed on the external surface of pipelines at discrete locations.
Andrea Carlino, Alberto Godio
doaj +1 more source
Electronic Notes in Theoretical Computer Science, 2007 AbstractWe present a method for pipeline verification using SMT solvers. It is based on a non-deterministic “mother pipeline” machine (MOP) that abstracts the instruction set architecture (ISA). The MOP vs. ISA correctness theorem splits naturally into a large number of simple subgoals.
Sava Krstic +2 more
openaire +1 more source
Molecular Oncology, EarlyView.Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena +15 more
wiley +1 more source
Journal of Engineering and Applied ScienceThis study conducts a computational fluid dynamics (CFD)-based assessment of internal corrosion risk in wet sour gas pipeline systems, focusing on developing a predictive framework for pipeline integrity. Using the L415 X60 steel pipeline as a reference,
Mavis Sika Okyere
doaj +1 more source