Results 51 to 60 of about 234,338 (249)

Optimization for Pipeline Corrosion Sensor Placement in Oil-Water Two-Phase Flow Using CFD Simulations and Genetic Algorithm

Sensors, 2023
Internal corrosion is a major concern in ensuring the safety of transmission and gathering pipelines in Structural Health Monitoring (SHM). It usually requires numerous sensors deployed inside the piping system to comprehensively cover the locations with
Shuomang Shi, Baiyu Jiang, Simone Ludwig, Luyang Xu, Hao Wang, Ying Huang, Fei Yan   +6 more
doaj   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

The Functional and the Instrumental in Market Definition: a Laboratory for Natural Experiments in the Baltics [PDF]

Baltic Region, 2018
Reforms of natural monopolies need clear delineations between the industries where market mechanisms contribute to social welfare and those where the costs of a transition to a market economy outweigh the benefits.
Shastitko A.E., Kurdin A.A.
doaj   +1 more source

Meta-Material Layout for the Blast Protection of Above-Ground Steel Pipes

Geotechnics, 2023
The current study investigates the capacity of the proposed meta-material layout for the blast protection of above-ground steel pipes against explosions.
Miltiadis Kontogeorgos, Clemente Fuggini
doaj   +1 more source

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

JWSTGiantPlanets/pipelines: v1.3.2

, 2023
<h2>What's Changed</h2> <ul> <li>Improve documentation & add <code>--kw</code> command line flag as optional alternative for <code>--step_kwargs</code> by @ortk95 in https://github.com/JWSTGiantPlanets ...
Oliver King
core   +1 more source

Development and characterization of PVC-based membranes embedded with magnetic silica core-shell composites for enhanced oil-water separation

Desalination and Water Treatment
A novel polyvinyl chloride (PVC)--based membrane incorporating magnetic silica core-shell nanoparticles (CoFe2O4@SiO2) was developed for efficient oil-water separation.
Rana H.M. EL Hady, Gheith, Mostafa M.H. Khalil, Mahmoud F. Mubarak   +3 more
doaj   +1 more source

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

Molecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur, Joel Rodrigues Vitória, Manuel Saiselet, Ligia Craciun, Denis Larsimont, Anne Lefort, Frédérick Libert, Carine Maenhaut, Sabine Costagliola, Maxime Tarabichi, Mirian Romitti, Vincent Detours   +11 more
wiley   +1 more source

The genome sequence of the Bird-cherry Ermine moth, Yponomeuta evonymella (Linnaeus, 1758) [version 2; peer review: 2 approved, 1 approved with reservations]

Wellcome Open Research
We present a genome assembly from an individual female Yponomeuta evonymella (the Bird-cherry Ermine; Arthropoda; Insecta; Lepidoptera; Yponomeutidae). The genome sequence has a total length of 572.70 megabases. Most of the assembly is scaffolded into 32
Douglas Boyes, Callum Murray
doaj   +1 more source

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

Molecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source